A5032668950- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 and healthcare impacts
- Asthma and respiratory diseases
- COVID-19 Clinical Research Studies
- Diversity and Career in Medicine
- Healthcare cost, quality, practices
- Acute Kidney Injury Research
- Healthcare Policy and Management
- Intensive Care Unit Cognitive Disorders
- Chronic Kidney Disease and Diabetes
- Hemodynamic Monitoring and Therapy
- Surgical site infection prevention
- IL-33, ST2, and ILC Pathways
- Sepsis Diagnosis and Treatment
- Global Health Workforce Issues
- Health and Medical Research Impacts
- Primary Care and Health Outcomes
- Heart Failure Treatment and Management
- Respiratory Support and Mechanisms
- Health disparities and outcomes
- Healthcare Systems and Reforms
- Social Media in Health Education
- Conferences and Exhibitions Management
- Migration, Health and Trauma
- Pediatric health and respiratory diseases
Royal London Hospital
2019-2024
Queen Mary University of London
2020-2024
William Harvey Research Institute
2020-2024
Barts Health NHS Trust
2019-2024
Griffith University
2022
University of Plymouth
2020
St George's Hospital
2020
University of Nottingham
2008-2014
Objective To describe outcomes within different ethnic groups of a cohort hospitalised patients with confirmed COVID-19 infection. quantify and the impact number prognostic factors, including frailty inflammatory markers. Setting Five acute National Health Service Hospitals in east London. Design Prospectively defined observational study using registry data. Participants 1737 aged 16 years or over admitted to hospital infection between 1 January 13 May 2020. Main outcome measures The primary...
<h3>Background</h3> The genetic basis for developing asthma has been extensively studied. However, association studies to date have mostly focused on mild moderate disease and risk factors severe remain unclear. <h3>Objective</h3> To identify common variants affecting susceptibility asthma. <h3>Methods</h3> A genome-wide study was undertaken in 933 European ancestry individuals with based Global Initiative Asthma (GINA) criteria 3 or above 3346 clean controls. After standard quality control...
Abstract Background and Aims Haemodynamic instability is associated with peri-operative myocardial injury, particularly in patients receiving renin–angiotensin system (RAS) inhibitors (angiotensin-converting-enzyme inhibitors/angiotensin II receptor blockers). Whether stopping RAS to minimise hypotension, or continuing avoid hypertension, reduces injury remains unclear. Methods From 31 July 2017 1 October 2021, aged ≥60 years undergoing elective non-cardiac surgery were randomly assigned...
Complications after surgery affect survival and quality of life. We aimed to confirm the relationship between postoperative complications death within 1 yr surgery.
Ongoing risk of death and poor functional outcomes are important consequences prolonged critical illness. Characterizing the catabolic phenotype illness could illuminate biological processes inform strategies to attenuate catabolism. We aimed examine if urea-to-creatinine ratio, a signature illness, was associated with mortality after first week ICU stay.Reanalysis multicenter randomized trial glutamine supplementation in (REducing Deaths due OXidative Stress [REDOXS]).Multiple adult...
Patients with elevated preoperative plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP >100 pg ml
Abstract Background The COVID-19 response required the cancellation of all but most urgent surgical procedures. number cancelled procedures owing to Covid-19, and reintroduction acivirt, was modelled. Methods This a modelling study using Hospital Episode Statistics data (2014–2019). Surgical were grouped into four urgency classes. Expected numbers performed between 1 March 2020 28 February 2021 Procedure deficit estimated conservative assumptions gradual elective surgery from June 2020....
<sec> <title>BACKGROUND</title> Hemophagocytic lymphohistiocytosis (HLH) is a rare and life-threatening condition predominantly affecting children, characterized by hyperinflammation high early mortality. While the HScore criteria, developed Fardet et al. in 2014, have been widely used to diagnose HLH, recent studies also explored its potential predict disease severity COVID-19 patients, with findings indicating that higher values correlate increased mortality risk may identify patients who...
Abstract Background Preliminary studies suggest that people from Black, Asian and Minority Ethnic (BAME) backgrounds experience higher mortality COVID-19 but the underlying reasons remain unclear. Methods Prospective analysis of registry data describing patients admitted to five acute NHS Hospitals in east London, UK for COVID-19. Emergency hospital admissions with confirmed SARS-CoV-2 aged 16 years or over were included. Data, including ethnicity, social deprivation, frailty, patient care...
It is unclear if changes in public behaviours, developments COVID-19 treatments, improved patient care, and directed policy initiatives have altered outcomes for minority ethnic groups the second pandemic wave. This was a prospective analysis of patients aged ≥ 16 years having an emergency admission with SARS-CoV-2 infection between 01/09/2020 17/02/2021 to acute NHS hospitals east London. Multivariable survival used assess associations ethnicity mortality accounting predefined risk factors....
Acute kidney injury (AKI) is a common and important complication of coronavirus disease 2019 (COVID-19). Further characterization required to reduce both short- long-term adverse outcomes.We examined registry data including adults with confirmed severe acute respiratory syndrome 2 (SARS-CoV-2) infection admitted five London Hospitals from 1 January 14 May 2020. Prior end-stage was excluded. Early AKI defined by Kidney Disease: Improving Global Outcomes creatinine criteria within 7 days...
Abstract Background Postoperative infection is one of the most frequent and important complications after surgery. The epidemiology following elective surgery remains poorly described. Methods This was a prospective analysis International Surgical Outcomes Study (ISOS) describing by 30 days Associations between postoperative (primary outcome) baseline demographic, surgical, anaesthetic risk factors were assessed. Analyses carried out using logistic linear regression models. Secondary...
BackgroundThe average number of times a person will have surgery in their lifetime, and the amount surgical healthcare resources they use, is unknown. Lifetime risk measure an having specific event within lifetime. We report lifetime change observed during first year COVID-19 pandemic.MethodsWe conducted population cohort study using hospital episode statistics to identify all patients undergoing between January 1, 2016, December 31, 2020, England. calculated age- sex-specific incidence...
Background: The effects of ethnic and social inequalities on patient outcomes in acute healthcare remain poorly understood.Methods: Prospectively-defined analysis registry data from four NHS hospitals east London including all patients ≥ 18 years with a first emergency admission between 1st January 2013 31st December 2018. We calculated adjusted one-year mortality risk using logistic regression. Results are presented as n (%), median (IQR), odds ratios (OR) 95% confidence intervals.Findings:...
The number of surgical extractions performed in hospitals England remains unclear. This study reports the volume conducted and change activity during COVID-19 pandemic.
BackgroundDifferences in routinely collected biomarkers between ethnic groups could reflect dysregulated host responses to disease and treatments, be associated with excess morbidity mortality COVID-19.MethodsA multicentre registry analysis from patients aged ≥16 yr SARS-CoV-2 infection emergency admission Barts Health NHS Trust hospitals during January 1, 2020 May 13, (wave 1) September February 17, 2021 2) was subjected unsupervised longitudinal clustering techniques identify distinct...
Abstract Background The response to COVID-19 has required cancellation of all but the most urgent surgeries, including many cancer operations. We estimated number cancelled surgical procedures in National Health Service (NHS) England due and how this deficit would change over time once elective surgery was reintroduced. Methods Modelling study using Hospital Episode Statistics (HES) data from 2014 2019. Using NHS definitions, were grouped into four classes urgency. calculated time-weighted...