A5028556058- Respiratory Support and Mechanisms
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Sepsis Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Intensive Care Unit Cognitive Disorders
- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Nosocomial Infections in ICU
- Traumatic Brain Injury and Neurovascular Disturbances
- Thermal Regulation in Medicine
- Renal function and acid-base balance
- Pneumonia and Respiratory Infections
- Trauma Management and Diagnosis
- Long-Term Effects of COVID-19
- Healthcare Systems and Reforms
- Inhalation and Respiratory Drug Delivery
- COVID-19 and healthcare impacts
- Abdominal Surgery and Complications
- Tracheal and airway disorders
- Vitamin C and Antioxidants Research
- Traumatic Ocular and Foreign Body Injuries
- Intracerebral and Subarachnoid Hemorrhage Research
- COVID-19 Clinical Research Studies
- Traumatic Brain Injury Research
Barts Health NHS Trust
2017-2022
William Harvey Research Institute
2018-2022
Royal London Hospital
2015-2021
Queen Mary University of London
2018-2021
Bury College
2008-2015
University College London
2009-2015
London Ambulance Service NHS Trust
2014
London Postgraduate Medical and Dental Education
2011
Hôpital Saint Roch
2010
Hôpital Cochin
2008
Abstract Background The widespread problem of antibiotic resistance in pathogens such as Staphylococcus aureus has prompted the search for new antimicrobial approaches. In this study we report first time use a light-activated agent, methylene blue, to kill an epidemic methicillin-resistant (EMRSA-16) strain two mouse wound models. Results Following irradiation wounds with 360 J/cm 2 laser light (670 nm) presence 100 μg/ml 25-fold reduction number viable EMRSA was seen. This independent...
Ventilator-associated pneumonia (VAP) is a major healthcare-associated complication with considerable attributable morbidity, mortality and cost. Inherent design flaws in the standard high-volume low-pressure cuffed tracheal tubes form part of pathogenic mechanism causing VAP. The formation folds inflated cuff leads to microaspiration pooled oropharyngeal secretions into trachea, biofilm on inner surface tube helps maintain bacterial colonization lower airways. Improved new material shape...
Acute Kidney Injury (AKI) complicating major trauma is associated with increased mortality and morbidity. Traumatic AKI has specific risk factors predictable time-course facilitating diagnostic modelling. In a single centre, retrospective observational study we developed prediction models for after based on data around intensive care admission. Models predicting were using from 830 patients, reduction followed by logistic regression, independently validated in further 564 patients. occurred...
Rodent models of sepsis are frequently used to investigate pathophysiological mechanisms and evaluate putative therapeutic strategies. However, preclinical efficacy in these has failed translate the clinical setting. We thus questioned representativeness such herein report a detailed comparison metabolic cardiovascular phenotypes long-term faecal peritonitis fluid-resuscitated rats mice with similar mortality profiles.We conducted prospective laboratory-controlled studies adult male Wistar...
Muscle dysfunction is a common feature of severe sepsis and multiorgan failure. Recent evidence implicates bioenergetic oxidative damage as important underlying pathophysiological mechanisms. Increased abundance uncoupling protein-3 (UCP3) in suggests increased mitochondrial proton leak, which may reduce coupling efficiency but limit reactive oxygen species (ROS) production. Using murine model, we examined metabolic, cardiovascular, skeletal muscle contractile changes following induction...
We present a single centre study describing the effect of awake prone position (PP) on oxygenation and clinical outcomes in spontaneously breathing patients with novel coronavirus disease (COVID-19). Between 1st March 30th April 2020, forty eight 138 managed outside critical care unit facemask oxygen, high flow nasal oxygen (HFNO) or continuous positive airway pressure (CPAP), underwent PP. Prone was associated significant improvement oxygenation, lower ICU admission, tracheal intubation,...
Nitric oxide-mediated activation of large conductance calcium-activated potassium (BK) channels is considered an important underlying mechanism sepsis-induced hypotension. Indeed, the nonselective K-channel inhibitor, tetraethylammonium chloride (TEA), has been proposed as a potential treatment to raise blood pressure in septic shock by virtue its ability inhibit BK channels. As experimental evidence so far relied on pharmacological inhibition, we examined effects channel deletion using BKα...
Traumatic Brain Injury (TBI) research is evolving. The quest for level-1 evidence through randomised prospective interventional trials, while useful to establish safety and efficacy, changing an era of big data observational studies. Comparative Effectiveness Research (CER) utilises the observation differences between treatments centres without strict inclusion/exclusion criteria or formal intervention [1]. In addition, transfer monitoring technologies into pre-hospital field will enable...
Evaluation of volaemia is a crucial question for the management patients during anaesthesia and in ICU. Numerous methods have been described, but there as yet no single ideal parameter. Another way to approach this problem predict extent hypovolaemia. The initial distribution volume glucose (IDVG) has shown development hypovolaemic hypotension following oesophageal surgery. In study, we evaluated use IDVG predicting hypovolemic after abdominal aortic surgery.All undergoing elective surgery...
Initial reports have suggested that COVID-19 SARS 2 virus is more prevalent and associated with increased severity in people diabetes.1 In a recent large series from the USA, diabetes mellitus was present as comorbidity over third of patients hospitalized COVID-19.2 study 658 confirmed COVID-19, three developed diabetic ketoacidosis (DKA).3 Clinical experience during crisis suggests DKA hyperglycaemic hyperosmolar syndrome (HHS) are common infection, significant insulin resistance,...
Prolonged hospital stay prior to admission the ICU was previously shown be independently associated with poorer outcome [1,2]. This is probably due slow deterioration of physiological function in and influenced by processes leading critical care [2]. We investigated whether commonly measured severity scoring systems (Acute Physiology Chronic Health Evaluation (APACHE) II, Intensive Care National Audit Research Centre (ICNARC) Sequential Organ Failure Assessment (SOFA) scores) are...
INTRODUCTION.Host infection by pathogens triggers an innate immune response leading to a systemic inflammatory response, often followed dysfunction which can favour the emergence of secondary infections.Dendritic cells (DCs) have unique ability link and adaptive immunity may be centrally involved in regulation sepsis-induced suppression.We previously reported that polymicrobial sepsis durably affects functions DCs confers long-term susceptibility P. aeruginosa pneumonia.In this study, we...
Ventilator-associated pneumonia (VAP) is associated with increased length of ventilation, ICU stay, mortality, cost and antibiotic burden [1]. There a large variation in reported rates VAP, partly as result inconsistencies definition [2]. We explored more pragmatic to describe the VAP rate, outcome 44-bed adult critical care unit level 1 trauma centre.