A5029710816- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Anesthesia and Pain Management
- Hip and Femur Fractures
- Delphi Technique in Research
- Enhanced Recovery After Surgery
- Cancer survivorship and care
- Clinical practice guidelines implementation
- Anesthesia and Sedative Agents
- Chronic Kidney Disease and Diabetes
- Frailty in Older Adults
- Electroconvulsive Therapy Studies
- Urological Disorders and Treatments
- Kidney Stones and Urolithiasis Treatments
- Pain Management and Opioid Use
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Nausea and vomiting management
- Cardiac Arrest and Resuscitation
- Heart Failure Treatment and Management
- Spine and Intervertebral Disc Pathology
- Bladder and Urothelial Cancer Treatments
- Acute Kidney Injury Research
- COVID-19 and healthcare impacts
- Blood transfusion and management
- Non-Invasive Vital Sign Monitoring
University of Bern
2020-2024
University Hospital of Bern
2019-2024
University of Toronto
2024
Sunnybrook Health Science Centre
2024
Health Sciences Centre
2024
Royal London Hospital
2016-2020
Barts Health NHS Trust
2016-2020
Queen Mary University of London
2015
Recently, the number of prehabilitation trials has increased significantly. The identification key research priorities is vital in guiding future directions. Thus, aim this collaborative study was to define for patients undergoing cancer surgery.The Delphi methodology implemented over three rounds surveys distributed experts from across multiple specialties, tumour streams and countries via a secure online platform. In first round, participants were asked provide baseline demographics...
Abstract Background Volume replacement with crystalloid fluid is the conventional treatment of hemorrhage. We challenged whether a standardized amount 5% or 20% albumin could be viable option to maintain blood volume during surgery associated major Therefore, aim this study was quantify and compare plasma expansion properties albumin, Ringer-lactate, when infused surgery. Methods In single-center randomized controlled trial, therapy combat hypovolemia hemorrhagic phase cystectomy randomly...
The use of cardiac output monitoring may improve patient outcomes after major surgery. However, little is known about the this technology across nations.This a secondary analysis previously published observational study. Patients aged 16 years and over undergoing non-cardiac surgery in 7-day period April 2011 were included into analysis. objective to describe prevalence type used Europe.Included 12,170 patients from surgical services 426 hospitals 28 European nations. One thousand four...
Introduction The global volume of surgery is growing and the population ageing, economic pressure rising. Major associated with relevant morbidity mortality. Postoperative reduction in physiological functional capacity especially marked elderly, multimorbid patient low fitness level, sarcopenia malnutrition. Interventions aiming to optimise prior (prehabilitation) may reduce postoperative complications consequently health costs. Methods analysis This a multicentre, multidisciplinary,...
Abstract Introduction The views of patients and carers are important for the development research priorities. This study aimed to determine compare top priorities cancer with those multidisciplinary clinicians expertise in prehabilitation. Materials methods cross-sectional surveyed recovering from surgery at a major tertiary hospital Sydney, Australia, and/or their between March July 2023. Consenting were provided list according prehabilitation, as determined recent International Delphi...
Objective To assess if uninterrupted anticoagulant agents’ administration affects blood loss and transfusion during open radical cystectomy (RC) urinary diversion. Patients Methods We conducted an observational single‐centre cohort study of a consecutive series 1430 RC patients, between 2000 2020. Blood was depicted according to body weight duration surgery (mL/kg/h), transfusion. The group ‘with considered performed with low‐dose aspirin (ASS), oral anticoagulants (OAC) international...
The aim of this study was to evaluate the feasibility opioid-free anesthesia (OFA) in open radical cystectomy (ORC) with urinary diversion and assess impact on recovery gastrointestinal function. We hypothesized that OFA would lead earlier bowel A total 44 patients who underwent standardized ORC were divided into two groups (OFA group vs. control group). In both groups, received epidural analgesia group: bupivacaine 0.25%, 0.1%, fentanyl 2 mcg/mL, epinephrine mcg/mL). primary endpoint time...
Abstract Background Prostatectomy is associated with relevant acute postoperative pain. Optimal analgesic techniques to minimize pain and enhance recovery are still under investigation. We aimed compare the effect of three different on quality recovery. Methods This investigator‐initiated, prospective, randomized, three‐arm, parallel‐group, active‐controlled, interventional superiority trial was performed in a Swiss teaching hospital from 2018 2021. Consecutive patients undergoing open or...
BackgroundPhysiological measures of heart failure are common in surgical patients, despite the absence a diagnosis. Heart rate (HR) increases during exercise frequently blunted (termed chronotropic incompetence), which primarily reflects beta-adrenoreceptor dysfunction. We examined whether incompetence was associated with myocardial injury after noncardiac surgery.MethodsThis predefined analysis an international cohort study where participants aged ≥40 yr underwent symptom-limited...
Preoperative dehydration is usually found in 30-50% of surgical patients, but the incidence unknown urologic population. We determined prevalence preoperative major elective urological surgery and studied its association with postoperative outcome, special attention to plasma creatinine changes. recruited 187 patients scheduled for abdominal participate a single-center study that used fluid retention index (FRI), which composite four urinary biomarkers correlate renal water conservation,...
Open radical cystectomy is associated with a substantial rate of perioperative blood transfusion. Early detection potentially modifiable factors could reduce the need for transfusion and thus positively impact outcome. We conducted an observational, single-center cohort study 1168 patients undergoing cystectomy. Perioperative was defined as packed red cells and/or fresh frozen plasma units within first 24 h after initiation surgery. Multiple logistic regression analysis performed to model...
The use of norepinephrine and the restriction intraoperative hydration have gained increasing acceptance over last few decades. Recently, there been concerns regarding impact this approach on renal function. objective study was to examine influence norepinephrine, fluid administration their interaction acute kidney injury (AKI) after cystectomy. In our cohort 1488 consecutive patients scheduled for cystectomies urinary diversions, overall incidence AKI 21.6% (95%-CI: 19.6% 23.8%) increased...
Purpose . Fluid therapy aimed at increasing urine output is a commonly employed strategy to prevent acute kidney injury (AKI) in critically ill patients with rhabdomyolysis. Automated fluid management has the potential optimise while avoiding accumulation rhabdomyolysis patients. Methods In single centre clinical service evaluation we compared convenience sample of adults treated automated using RenalGuard® device managed manual adjustment following our standard protocol. Primary outcome was...
Objectives To determine whether early acute kidney injury affects mid‐term renal function, to identify risk factors for impaired and highlight the evolution of plasma creatinine estimated glomerular filtration rate in first 12 months after cystectomy urinary diversion. Methods We conducted a single‐center retrospective observational cohort study from 2000 2019. included 900 consecutive patients undergoing Patients with incomplete data preoperative hemodialysis were excluded. Early was...
Abstract Background Low functional capacity in patients undergoing major elective surgery is associated with postoperative complications. Prehabilitation aims to increase by increasing preoperative physical activity. eligible for high age and comorbid burden. In this population, center-based prehabilitation a barrier participation. Therefore, we developed multimodal home-based intervention. Data regarding the effectiveness of intervention activity before limited. We hypothesize that leads an...