A5085465156- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Aortic aneurysm repair treatments
- Meta-analysis and systematic reviews
- Nausea and vomiting management
- Health Systems, Economic Evaluations, Quality of Life
- Anesthesia and Pain Management
- Enhanced Recovery After Surgery
- Aortic Disease and Treatment Approaches
- Airway Management and Intubation Techniques
- Anesthesia and Sedative Agents
- Blood Pressure and Hypertension Studies
- Colorectal Cancer Surgical Treatments
- Cardiovascular and exercise physiology
- Health and Medical Research Impacts
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- Artificial Intelligence in Healthcare and Education
- Cardiovascular Function and Risk Factors
- Pneumonia and Respiratory Infections
- Statistical Methods in Clinical Trials
- Delphi Technique in Research
- Cardiac Arrest and Resuscitation
- Streptococcal Infections and Treatments
- Hip and Femur Fractures
Torbay Hospital
2013-2024
Torbay and South Devon NHS Foundation Trust
2006-2024
Barts Health NHS Trust
2017
Ghent University Hospital
2011
Paracelsus Medical University
2011
Queensland Health
2001
Naval Medical Center San Diego
1987-1988
Regional Medical Center
1987
Summary Healthcare workers involved in aerosol‐generating procedures, such as tracheal intubation, may be at elevated risk of acquiring COVID‐19. However, the magnitude this is unknown. We conducted a prospective international multicentre cohort study recruiting healthcare participating intubation patients with suspected or confirmed Information on episodes, personal protective equipment use and subsequent provider health status was collected via self‐reporting. The primary endpoint...
Randomised, controlled trials have been retracted after publication because of data fabrication and inadequate ethical approval. Fabricated included baseline variables, for instance, age, height or weight. Statistical tests can determine the probability distribution means, given their standard deviation number participants in each group. distributions calculated as improbable. Most written by anaesthetists published specialist anaesthetic journals. I wanted to explore whether was consistent...
This guideline aims to ensure that patients admitted hospital for elective surgery are known have blood pressures below 160 mmHg systolic and 100 diastolic in primary care. The objective care is fulfil this criterion before referral secondary surgery. avoid spurious hypertensive measurements. Secondary should not attempt diagnose hypertension who normotensive Patients present pre-operative assessment clinics without documented proceed if clinic 180 110 diastolic.
We examined, in age subsets, 2643 patients with acute myocardial infarction. Clinical features and 1 year morbidity mortality were compared 203 young (less than 45 years), 1671 46 to 70 years old, 769 elderly (greater years). Ninety-two percent of men, a family history premature coronary artery disease was more common (41% 28% middle-aged 12% patients). More currently smoking cigarettes (82% 56% 24% patients), only 8% had never smoked. Previous infarction angina pectoris or congestive heart...
Abstract Background Cardiopulmonary exercise (CPX) testing measures how efficiently subjects meet increased metabolic demand. This study aimed to determine whether preoperative CPX predicted postoperative survival following elective abdominal aortic aneurysm (AAA) repair. Methods Some 130 patients had before open AAA Additional preoperative, operative and variables were recorded prospectively. Median follow-up was 35 months. The correlation of with assessed by single multiple regression...
The purpose of these guidelines on the preoperative evaluation adult non-cardiac surgery patient is to present recommendations based available relevant clinical evidence. ultimate aims are two-fold. First, we aim identify those patients for whom perioperative period may constitute an increased risk morbidity and mortality, aside from risks associated with underlying disease. Second, this should help us design strategies that reduce additional risks. Very few well performed randomised studies...
Concerned that studies contain false data, I analysed the baseline summary data of randomised controlled trials when they were submitted to Anaesthesia from February 2017 March 2020. categorised with as 'zombie' if thought trial was fatally flawed. 526 trials: 73 (14%) had and 43 (8%) zombie. Individual patient increased detection categorisation zombie compared without individual data: 67/153 (44%) vs. 6/373 (2%) false; 40/153 (26%) 3/373 (1%) zombie, respectively. The analysis independently...
Introduction Randomised controlled trials (RCTs) inform healthcare decisions. It is now apparent that some published RCTs contain false data and appear to have been entirely fabricated. Systematic reviews are performed identify synthesise all conducted on a given topic. While it usual assess methodological features of the in process undertaking systematic review, not consider whether data. Studies containing therefore go unnoticed contribute review conclusions. The INveStigating ProblEmatic...
In a previous paper, one of the authors (JBC) used chi-squared method to analyse means (SD) baseline variables, such as height or weight, from randomised controlled trials by Fujii et al., concluding that probabilities reported distributions arose chance were infinitesimally small. Subsequent testing method, using simulation, suggested was incorrect. This paper corrects and tests its performance Monte Carlo simulations ANOVA probability random sampling. The corrected became inaccurate when...
Summary We observed survival after scheduled repair of abdominal aortic aneurysm in 1096 patients for a median ( IQR [range]) 3.0 (1.5–5.8 [0–15]) years: 943 had complete data, 250 whom died. compared discrimination and calibration an external model with the Kaplan–Meier generated from study data. Integrated Brier misclassification scores both models at 1–5 postoperative years were 0.04, 0.08, 0.11, 0.13 0.16, respectively. Harrel's concordance index was 0.73, 0.71, 0.68, 0.67 0.66, Groups...
Summary A large number of randomised trials authored by Yoshitaka Fujii have been retracted, in part as a consequence previous analysis finding very low probability random sampling. Dr Yuhji Saitoh co‐authored 34 those and he was corresponding author for eight them. We found additional randomised, controlled that included baseline data, with author, did not co‐author. used Monte Carlo simulations to analyse the data from 32 relevant total well an outcome (muscle twitch recovery ratios)...
Doubt is not a pleasant condition, but certainty an absurd one. – Voltaire 1 Last year, Anaesthesia published 24 review articles. A glance at the Journal covers shows that these varied only in subject matter, also scope and methodology. Of articles, 11 were systematic reviews with meta-analysis (e.g. 2, 3), one was meta-regression, two without statistical combination of data 4, 5, which described as 'qualitative' 4. The remaining 13 what would describe 'narrative reviews' (for instance 6,...
Background Determining optimal management of colorectal polyps in patients with limited life expectancy under 10 years can be difficult, due to challenges balancing an uncertain natural history polyp progression symptomatic malignancy versus the increased risk and consequences polypectomy complications. Aim This British Society Gastroenterology Association Coloproctologists Great Britain Ireland guidance aims help clinicians consider these risks aid decision-making for a conservative...
Evidence for the benefit of critical care after surgery is limited. This study assessed value immediate admission to unit (CCU) open colorectal surgery.Patients aged over 45 years were screened with a cardiopulmonary exercise test determine their anaerobic threshold. Less fit patients defined by an threshold below 11 ml oxygen per kg min assigned either or surgical ward care. Those above The outcome measure was number cardiac events.Of 153 who underwent testing, 55 had at least (ward care)...