A5052875343- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Colorectal Cancer Screening and Detection
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Microscopic Colitis
- Child Nutrition and Feeding Issues
- Dysphagia Assessment and Management
- Gastrointestinal motility and disorders
- COVID-19 Clinical Research Studies
- Diverticular Disease and Complications
- Gallbladder and Bile Duct Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Gastrointestinal Bleeding Diagnosis and Treatment
- Clinical Nutrition and Gastroenterology
- Gastrointestinal Tumor Research and Treatment
- Pancreatitis Pathology and Treatment
- Gastrointestinal disorders and treatments
- Venous Thromboembolism Diagnosis and Management
- Lung Cancer Diagnosis and Treatment
University of Birmingham
2011-2025
Sandwell & West Birmingham Hospitals NHS Trust
2016-2025
Sandwell General Hospital
2016-2025
Oxford Health NHS Foundation Trust
2025
University Hospitals Birmingham NHS Foundation Trust
2024
Queen Elizabeth Hospital
2024
NIHR Surgical Reconstruction and Microbiology Research Centre
2023
Medical Research Council
2021
University of Leicester
2021
University of Dundee
2021
These guidelines provide a practical and evidence-based resource for the management of patients with Barrett9s oesophagus related early neoplasia. The Appraisal Guidelines Research Evaluation (AGREE II) instrument was followed to methodological strategy guideline development. A systematic review literature performed English language articles published up until December 2012 in order address controversial issues including definition, screening diagnosis, surveillance, pathological grading...
Upper gastrointestinal (UGI) cancer in the Western world usually presents at an advanced stage, when opportunities for curative therapy are limited. The failure to detect subtle, early-stage UGI endoscopy may contribute a poor prognosis. We undertook meta-analysis of studies endoscopic miss rates quantify how often diagnose earlier stage missed.A MEDLINE search was conducted identify relevant studies, and conducted. "Missed" defined as that had not been diagnosed by performed within 3 years...
This document represents the first position statement produced by British Society of Gastroenterology and Association Upper Gastrointestinal Surgeons Great Britain Ireland, setting out minimum expected standards in diagnostic upper gastrointestinal endoscopy. The need for this has arisen from recognition that while technical competence can be rapidly acquired, practice performance a high-quality examination is variable, with an unacceptably high rate failure to diagnose cancer at importance...
Oesophageal adenocarcinoma is the sixth most common cause of cancer death worldwide and Barrett's oesophagus biggest risk factor. We aimed to evaluate efficacy high-dose esomeprazole proton-pump inhibitor (PPI) aspirin for improving outcomes in patients with oesophagus.
Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within HLA region) and 16q23, where closest protein-coding gene is FOXF1. Subsequently, Esophageal Adenocarcinoma Consortium (BEACON) identified loci for near CRTC1 BARX1, within 100 kb FOXP1. aimed identify further SNPs that increased validate previously reported associations.
These guidelines on oesophageal manometry and gastro-oesophageal reflux monitoring supersede those produced in 2006. Since 2006 there have been significant technological advances, particular, the development of high resolution (HRM) impedance monitoring. The were developed by a guideline group patients representatives all relevant professional groups using Appraisal Guidelines for Research Evaluation (AGREE II) tool. A systematic literature search was performed GRADE (Grading Recommendations...
Summary Background Data regarding incidence, prevalence and long‐term outcomes of inflammatory bowel diseases in the UK are limited or outdated. Aims To investigate incidence Crohn's disease ulcerative colitis risk colorectal cancer all‐cause mortality these diseases. Methods Inflammatory cases between 2000 2018 were identified from a national primary care database. was forecast until 2025. The association investigated using age/sex‐matched retrospective cohort studies. Hazard ratios...
Over 2.5 million gastrointestinal endoscopic procedures are carried out in the United Kingdom (UK) every year. Procedures with local anaesthetic r sedation. Sedation is commonly used for endoscopy, but type and amount of sedation administered influenced by complexity nature procedure patient factors. The elective emergency endoscopy resources also have a significant impact on delivery In UK, vast majority sedated using benzodiazepines, or without opiates, whereas deeper propofol general...
Objective This national analysis aimed to calculate the diagnostic yield from gastroscopy for common symptoms, guiding improved resource utilisation. Design A cross-sectional study was conducted of gastroscopies between 1 March 2019 and 29 February 2020 using UK National Endoscopy Database. Mixed-effect logistic regression models were used, incorporating random (endoscopist) fixed (symptoms, age sex) effects on two dependent variables (endoscopic cancer; Barrett’s oesophagus (BO) diagnosis)....
Studies of the relative frequency transient lower esophageal sphincter relaxations (TLESRs) in patients with gastroesophageal reflux disease and asymptomatic controls have revealed conflicting data. We therefore studied TLESRs mechanisms acid episodes age- sex-matched using standardized criteria.Ten symptomatic (four male, aged 50 [30-59] yr) 10 matched volunteers [32-59] were studied. Esophageal, sphincter, gastric manometric pH readings recorded for 1 h before after a 200-kcal, 150 ml...
Background —The incidence of adenocarcinoma the oesophagus and gastric cardia is increasing rapidly. Barrett’s major risk factor. Intestinal metaplasia at squamocolumnar junction in absence common but its relation to gastro-oesophageal reflux disease unclear. Aims —To study prevalence clinical, endoscopic, histological associations intestinal junction. Methods —Biopsy specimens were taken from 120 randomly selected patients undergoing routine diagnostic endoscopy. Eight biopsy specimens,...
Summary Aim: To examine the prevalence of gastro‐oesophageal reflux disease symptoms and potential risk factors among community subjects. Methods: A questionnaire was sent to 4000 subjects, stratified by age, gender ethnicity be representative local population. Gastro‐oesophageal were defined as at least weekly heartburn or acid regurgitation. Results: 2231 responded (59%), 691 refused participate seven incomplete. 1533 (41%) evaluable (637 male, mean age 51 years, range: 20–80). The 21%....
BACKGROUND Aggregation of symptoms abdominal pain or bowel disturbance has been described in the families patients with irritable syndrome (IBS). This may be due to environmental factors, including learned responses a genetic contribution etiology IBS. OBJECTIVES To determine relative factors IBS by evaluating monozygotic (MZ) and dizygotic (DZ) twins. METHODS A total 4,480 unselected twin pairs identified from national volunteer register were asked complete validated questionnaire. was...
Relieving obstructive jaundice in inoperable pancreato-biliary cancers improves quality of life and permits chemotherapy. Percutaneous transhepatic cholangiography with drainage and/or stenting relieves but can be associated significant morbidity mortality. biliary (PTBD) malignant obstruction was therefore examined a national cohort to establish risk factors for poor outcomes.Retrospective study adult patients undergoing PTBD palliation cancer England between 2001 2014 identified from...
The aim of this study was to develop a predictive model for overall survival after esophagectomy using pre/postoperative clinical data and machine learning.
Summary Background Patients with active inflammatory bowel disease (IBD) and mental illnesses experience worse IBD outcomes. Aim To describe the incidence of illnesses, including deliberate self‐harm, in patients. Methods A population‐based retrospective cohort study using IQVIA medical research data a primary care database covering whole UK, between January 1995 2021. patients all ages were matched 4:1 by demographics practice to unexposed controls. Following exclusion ill health at entry,...
Barrett’s oesophagus is the only known precursor to oesophageal adenocarcinoma, a cancer with very poor prognosis. The main risk factors for are history of gastro-oesophageal acid reflux symptoms and obesity. Men, smokers those family also at increased risk. Progression from occurs via an intermediate stage, as dysplasia. However, dysplasia early usually develop without any clinical signs, often in individuals whose well controlled by suppressant medications; therefore, endoscopic...
Objective: A number of case reports describe multiple family members with gastroesophageal reflux disease and Barrett's esophagus. The wider importance familial factors in has not been established. Therefore, we have studied the prevalence symptoms medication use among relatives patients documented disease. Methods: postal questionnaire study first degree six groups matched patients. comprised 1) no dyspeptic symptoms; 2) a normal pH study; 3) symptoms, an abnormal study, lower esophageal...