Stephen Attwood
A5070631799- Eosinophilic Esophagitis
- Eosinophilic Disorders and Syndromes
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Hernia repair and management
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Clinical practice guidelines implementation
- Inflammatory mediators and NSAID effects
- Gastrointestinal disorders and treatments
- Minimally Invasive Surgical Techniques
- Yersinia bacterium, plague, ectoparasites research
- Appendicitis Diagnosis and Management
- Healthcare cost, quality, practices
- Colorectal Cancer Surgical Treatments
- Pelvic floor disorders treatments
- Diabetes Management and Education
- Pancreatitis Pathology and Treatment
- Intraperitoneal and Appendiceal Malignancies
- IL-33, ST2, and ILC Pathways
- Primary Care and Health Outcomes
- Respiratory and Cough-Related Research
Durham University
2014-2024
NIHR Clinical Research Network
2023
North Tyneside General Hospital
2009-2022
Oxfordshire Clinical Commissioning Group
2018-2020
Bicester Community Hospital
2018
Northumbria Healthcare NHS Foundation Trust
2005-2017
Northern Health and Social Care Trust
2016
National Health Service
2008-2012
Bristol Royal Infirmary
2012
Homerton University Hospital
2012
Background Barrett's esophagus (BE) is a commonly undiagnosed condition that predisposes to esophageal adenocarcinoma. Routine endoscopic screening for BE not recommended because of the burden this would impose on health care system. The objective study was determine whether novel approach using minimally invasive cell sampling device, Cytosponge, coupled with immunohistochemical staining biomarker Trefoil Factor 3 (TFF3), could be used identify patients who warrant endoscopy diagnose BE....
Background & AimsSwallowed topical-acting corticosteroids are recommended as first-line therapy for eosinophilic esophagitis (EoE). Asthma medications not optimized esophageal delivery sometimes effective, although given off-label. We performed a randomized, placebo-controlled trial to assess the effectiveness and tolerability of budesonide orodispersible tablet (BOT), which allows drug be delivered esophagus in adults with active EoE.MethodsWe double-blind, parallel study 88 EoE Europe....
Oesophageal adenocarcinoma is the sixth most common cause of cancer death worldwide and Barrett's oesophagus biggest risk factor. We aimed to evaluate efficacy high-dose esomeprazole proton-pump inhibitor (PPI) aspirin for improving outcomes in patients with oesophagus.
Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder. Swallowed topical-acting corticosteroids are effective in bringing active EoE into remission. However, it not clear whether these drugs for long-term maintenance of remission.We performed double-blind trial to compare the efficacy and safety 2 dosages budesonide orodispersible tablet (BOT) vs placebo maintaining remission EoE. Maintenance was defined as absence clinical histologic relapse no premature withdrawal any reason....
<b>Background:</b> Eosinophilic oesophagitis is a rarely diagnosed condition involving eosinophil infiltration of the oesophageal mucosa and creating significant symptoms dysphagia. Failure to diagnose this disorder relates reluctance biopsy an apparently normal oesophagus. This essential for histological diagnosis. To date, treatment success has been achieved only with corticosteroids. We describe here use stabilising agent Montelukast symptomatic relief these patients. <b>Patients...
<h3>Background:</h3> With the introduction of laparoscopic antireflux surgery (LARS) for gastro-oesophageal reflux disease (GORD) along with increasing efficacy modern medical treatment, a direct comparison is warranted. The 3-year interim results randomised study comparing both and safety LARS esomeprazole (ESO) are reported. <h3>Methods:</h3> LOTUS an open, parallel-group multicentre, controlled trial conducted in dedicated centres 11 European countries. was completed according to...
Summary Background Control of chronic gastro‐oesophageal reflux disease may be achieved either by anti‐reflux surgery ( ARS ) or long‐term medical therapy with proton pump inhibitors PPI s). The primary efficacy results the SOPRAN study, comparing omeprazole use open , and LOTUS esomeprazole laparoscopic have been reported. A secondary objective these studies was to address safety respective therapeutic strategies thereby provide a valid scientific platform for assessing safety. Aim To...
These are updated guidelines which supersede the original version published in 2004. This work has been endorsed by Clinical Services and Standards Committee of British Society Gastroenterology (BSG) under auspices oesophageal section BSG. The have undergone extensive revision 16 members Guideline Development Group with representation from individuals across all relevant disciplines, including Heartburn Cancer UK charity, a nursing representative patient representative. methodological rigour...
Objective Antireflux surgery can be proposed in patients with GORD, especially when proton pump inhibitor (PPI) use leads to incomplete symptom improvement. However, date, international consensus guidelines on the clinical criteria and additional technical examinations used patient selection for antireflux are lacking. We aimed at generating key recommendations of surgery. Design included 35 experts (gastroenterologists, surgeons physiologists) a Delphi process developed 37 statements that...
OBJECTIVES To assess the variation in practice of Barrett's esophagus (BE) management comparison with accepted international guidelines before and after introduction a large BE randomized controlled trial (RCT) protocols including those tissue sampling. DESIGN A validated anonymized questionnaire was sent to 401 senior attending gastroenterologists asking for details their current BE, especially histological Of 228 respondents, 57 individuals (each from different center) were first group...
Aims Reflux symptoms are highly prevalent and non‐specific; hence, in the absence of alarm symptoms, endoscopy referral decisions challenging. This study evaluated whether a non‐endoscopic Cytosponge could detect benign oesophageal pathologies thus have future potential triaging patients with persistent symptoms. Methods results Two complementary cohorts were recruited: (i) reflux no prior ( n = 409), (ii) referred for 411). All investigated using endoscopy. Significant epithelial...
Abstract Background A novel budesonide orodispersible tablet (BOT) has been proven effective in adult patients with active eosinophilic oesophagitis (EoE) a 6‐week placebo‐controlled trial (EOS‐1). Aims To report the efficacy of an open‐label induction treatment BOT large prospective cohort EoE within EOS‐2 study. Methods Patients clinico‐histological were treated 1 mg BID for 6 weeks. The primary endpoint was remission (≤2 points on numerical rating scales [0–10] each dysphagia and...
There is considerable controversy regarding optimal management of patients with paraesophageal hiatus hernia (pHH). This survey aims at identifying recommended strategies for work-up, surgical therapy, and postoperative follow-up using Delphi methodology.We conducted a 2-round, 33-question, web-based on perioperative (preoperative procedure follow-up) non-revisional, elective pHH among European surgeons expertise in upper-GI. Responses were graded 5-point Likert scale analyzed descriptive...