A5101854206- Celiac Disease Research and Management
- Microscopic Colitis
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Gastroesophageal reflux and treatments
- Gastrointestinal disorders and treatments
- Digestive system and related health
- Esophageal and GI Pathology
- Gastrointestinal motility and disorders
- Dysphagia Assessment and Management
- Genetic factors in colorectal cancer
- Gut microbiota and health
- Galectins and Cancer Biology
- Autoimmune Bullous Skin Diseases
- Inflammatory Bowel Disease
- Eosinophilic Disorders and Syndromes
- Chronic Lymphocytic Leukemia Research
- Viral gastroenteritis research and epidemiology
- Esophageal Cancer Research and Treatment
- Microbial Metabolites in Food Biotechnology
- Potassium and Related Disorders
- Intestinal and Peritoneal Adhesions
- Gastric Cancer Management and Outcomes
- Nitric Oxide and Endothelin Effects
- Clostridium difficile and Clostridium perfringens research
Mayo Clinic
2015-2024
WinnMed
2015-2024
Mayo Clinic in Arizona
2015-2024
Boston Children's Hospital
2024
Harvard University
2024
University of New Hampshire
2024
Royal United Hospital Bath NHS Trust
2024
Tampere University
2019-2023
Io Therapeutics (United States)
2023
Takeda (Japan)
2023
<h3>Background</h3> Celiac disease (CD) is an immune-mediated enteropathic condition triggered in genetically susceptible individuals by the ingestion of gluten. Although common Europe, CD thought to be rare United States, where there are no large epidemiologic studies its prevalence. The aim this study was determine prevalence at-risk and not-at-risk groups States. <h3>Methods</h3> Serum antigliadin antibodies anti–endomysial (EMA) were measured. In EMA-positive subjects, human tissue...
This guideline presents recommendations for the diagnosis and management of patients with celiac disease. Celiac disease is an immune-based reaction to dietary gluten (storage protein wheat, barley, rye) that primarily affects small intestine in those a genetic predisposition resolves exclusion from diet. There has been substantial increase prevalence over last 50 years rate 10 years. can present many symptoms, including typical gastrointestinal symptoms (e.g., diarrhea, steatorrhea, weight...
<h3>Objective</h3> The literature suggests a lack of consensus on the use terms related to coeliac disease (CD) and gluten. <h3>Design</h3> A multidisciplinary task force 16 physicians from seven countries used electronic database PubMed review for CD-related up January 2011. Teams then suggested definition each term, followed by feedback these definitions through web survey definitions, discussions during meeting in Oslo phone conferences. In addition ‘CD’, following descriptors CD were...
Celiac disease is an immune-mediated enteropathy caused by a permanent sensitivity to gluten in genetically susceptible individuals. It occurs children and adolescents with gastrointestinal symptoms, dermatitis herpetiformis, dental enamel defects, osteoporosis, short stature, delayed puberty persistent iron deficiency anemia asymptomatic individuals type 1 diabetes, Down syndrome, Turner Williams selective immunoglobulin (Ig)A first degree relatives of celiac disease. The Disease Guideline...
A multidisciplinary panel of 18 physicians and 3 non-physicians from eight countries (Sweden, UK, Argentina, Australia, Italy, Finland, Norway the USA) reviewed literature on diagnosis management adult coeliac disease (CD). This paper presents recommendations British Society Gastroenterology. Areas controversies were explored through phone meetings web surveys. Nine working groups examined following areas CD management: classification CD; genetics immunology; diagnostics; serology endoscopy;...
Abstract Multiple sclerosis (MS) is an immune-mediated disease, the etiology of which involves both genetic and environmental factors. The exact nature factors responsible for predisposition to MS remains elusive; however, it’s hypothesized that gastrointestinal microbiota might play important role in pathogenesis MS. Therefore, this study was designed investigate whether gut are altered by comparing fecal relapsing remitting (RRMS) (n = 31) patients age- gender-matched healthy controls 36)....
OBJECTIVES: The prevalence of celiac disease (CD) in the United States is unknown. We sought to estimate CD nationwide by using a nationally representative sample. METHODS: This study included 7,798 persons aged 6 years or older who participated National Health and Nutrition Examination Survey 2009–2010. Serum samples from all participants were tested for immunoglobulin A (IgA) tissue transglutaminase antibodies and, if findings abnormal, also IgA endomysial antibodies. Information about...
The adaptive immune response in rheumatoid arthritis (RA) is influenced by an interaction between host genetics and environment, particularly the microbiome. Association of gut microbiota with various diseases has been reported, though specific components that affect leading to disease remain unknown. However, there limited information on role RA. In this study we aimed define a microbial metabolite profile could predict status. addition, generate humanized model confirm RA-associated...
OBJECTIVES Impedance monitoring is a new diagnostic method for gastroesophageal reflux disease (GERD) where multiple impedance electrode pairs are placed on standard pH catheter. It detects of liquid and/or gas bolus into the esophagus, as well its distribution, composition, and clearing. The aim this collaborative study to define normal values 24-h ambulatory simultaneous (24-h Imp-pH), compare parameters by changes in [H+] measured monitoring. METHODS Sixty volunteers without GER symptoms...
ObjectiveTo report the response to discontinuation of olmesartan, an angiotensin II receptor antagonist commonly prescribed for treatment hypertension, in patients with unexplained severe spruelike enteropathy.Patients and MethodsAll 22 included this were seen at Mayo Clinic Rochester, Minnesota, between August 1, 2008, 2011, evaluation chronic diarrhea enteropathy while taking olmesartan. Celiac disease was ruled out all cases. To be study, also had have clinical improvement after...
Clinical response is typically observed in most adults with celiac disease (CD) after treatment a gluten-free diet (GFD). The rate of mucosal recovery less certain. aims this study were (1) to estimate the GFD cohort CD, and (2) assess clinical implications persistent damage GFD.The group included biopsy-proven CD evaluated at Mayo Clinic who had duodenal biopsies diagnosis least one follow-up intestinal biopsy starting GFD. primary outcomes interest all-cause mortality.Of 381 241 (73%...
The prevalence of celiac disease (CD) varies greatly, potentially because incomplete ascertainment cases and small study samples with limited statistical power. Previous reports indicate that the incidence CD is increasing. We examined in a well-defined US county.Population-based Olmsted County, Minnesota, USA. Using infrastructure Rochester Epidemiology Project, medical, histopathology, serology records were used to identify all new County since 2000. Age- sex-specific adjusted (to white...
Background: Celiac disease (CD) is associated with an increased risk for lymphoproliferative malignancy (LPM). Whether this affected by the results of follow-up intestinal biopsy, performed to document mucosal healing, unknown. Objective: To examine association between healing in CD and subsequent LPM. Design: Population-based cohort study. Setting: 28 pathology departments Sweden. Patients: 7625 patients who had biopsy after initial diagnosis. Measurements: The LPM was compared that general...
The human gut is colonized by a large number of microorganisms (∼1013 bacteria) that support various physiologic functions. A perturbation in the healthy microbiome might lead to development inflammatory diseases, such as multiple sclerosis (MS). Therefore, commensals provide promising therapeutic options for treating MS and other diseases. We report identification gut-derived commensal bacteria, Prevotella histicola, which can suppress experimental autoimmune encephalomyelitis (EAE)...