A5012104405- Celiac Disease Research and Management
- Microscopic Colitis
- Galectins and Cancer Biology
- Eosinophilic Esophagitis
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Inflammatory Bowel Disease
- Helicobacter pylori-related gastroenterology studies
- Digestive system and related health
- Diabetes and associated disorders
- Autoimmune Bullous Skin Diseases
- Immunodeficiency and Autoimmune Disorders
- Viral Infections and Immunology Research
- Biosimilars and Bioanalytical Methods
- Microbial Metabolites in Food Biotechnology
- Pharmaceutical studies and practices
- Mycobacterium research and diagnosis
- Systemic Sclerosis and Related Diseases
- Viral gastroenteritis research and epidemiology
- Transgenic Plants and Applications
- Immunotherapy and Immune Responses
- Gastrointestinal disorders and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Liver Diseases and Immunity
University of Oslo
2016-2025
Oslo University Hospital
2016-2025
657 Oslo
1999-2023
Institute of Clinical Research
2023
Coeliac UK
2022
Palmerston North Hospital
2019
Skedsmo Medisinske Senter
2017
Tampere University Hospital
2016
Tampere University
2016
Immune Regulation (United Kingdom)
2014
A multidisciplinary panel of 18 physicians and 3 non-physicians from eight countries (Sweden, UK, Argentina, Australia, Italy, Finland, Norway the USA) reviewed literature on diagnosis management adult coeliac disease (CD). This paper presents recommendations British Society Gastroenterology. Areas controversies were explored through phone meetings web surveys. Nine working groups examined following areas CD management: classification CD; genetics immunology; diagnostics; serology endoscopy;...
This guideline presents recommendations for the management of coeliac disease (CD) and other gluten-related disorders both in adults children. There has been a substantial increase prevalence CD over last 50 years many patients remain undiagnosed. Diagnostic testing, including serology biopsy, should be performed on gluten-containing diet. The diagnosis is based combination clinical, serological histopathological data. In group children may made without biopsy if strict criteria are...
The great majority of patients that are intolerant wheat gluten protein due to celiac disease (CD) human histocompatibility leukocyte antigen (HLA)-DQ2+, and the remaining few normally express HLA-DQ8. These two class II molecules chiefly responsible for presentation peptides gluten-specific T cells found only in gut CD but not controls. Interestingly, tissue transglutaminase (tTG)-mediated deamidation gliadin plays an important role recognition this food by intestinal cells. Here we have...
Celiac disease (CD) is most probably an immunological disease, precipitated in susceptible individuals by ingestion of wheat gliadin and related proteins from other cereals. The shows a strong human HLA association predominantly to the cis or trans encoded HLA-DQ(alpha 1*0501,beta 1*0201) (DQ2) heterodimer. T cell recognition presented this DQ heterodimer may thus be immunopathogenic importance CD. We therefore challenged small intestinal biopsies adult CD patients on gluten-free diet vitro...
Non-Celiac Gluten Sensitivity (NCGS) is a syndrome characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food, in subjects that are not affected either celiac disease or wheat allergy. Given lack NCGS biomarker, there need for standardizing procedure leading diagnosis confirmation. In this paper we report experts’ recommendations on how diagnostic protocol should be performed confirmation NCGS. A full assess clinical response gluten-free diet...
In celiac disease, small intestinal transglutaminase 2 causes deamidation of glutamine residues in gluten peptides, which enhances stimulation T cells and leads to mucosal injury. Inhibition is a potential treatment for disease.In proof-of-concept trial, we assessed the efficacy safety 6-week with ZED1227, selective oral inhibitor, at three dose levels as compared placebo, adults well-controlled disease who underwent daily challenge. The primary end point was attenuation gluten-induced...
Coeliac disease is precipitated in susceptible subjects by ingestion of wheat gluten or related prolamins from some other cereals. The strongly associated with certain HLA-DQ heterodimers, for example, DQ2 (DQ alpha 1*0501, beta 1*0201) most patients and apparently DQ8 1*0301, 1*0302) a small subset. Gluten specific T cell clones (TCC) coeliac intestinal lesions were recently established found to be mainly restricted HLA-DQ2 HLA-DQ8. Antigen induced production cytokines was studied 15 TCC...
Endomysial antibodies are a hallmark of coeliac disease. The existence autoantibodies whose titres fluctuate with ingestion gliadin is enigmatic. Gliadin seems to drive this antibody secretion as endomysial produced in biopsy samples cultured peptic/tryptic digest gliadin.1 phenomenon has been explained by molecular mimicry between and the antigen, or unmasking cryptic epitopes antigen upon exposure 2Recently, Dieterich colleagues identified tissue transglutaminase (tTG) for antibodies.3...
Celiac disease is a small intestinal inflammatory disorder characterized by malabsorption, nutrient deficiency, and range of clinical manifestations. It caused an inappropriate immune response to dietary gluten treated with gluten-free diet. Recent feeding studies have indicated oats be safe for celiac patients, are now often included in the This study aimed investigate whether oat intolerance exists characterize cells processes underlying this intolerance.We selected nine adults who had...
The current trend is to allow coeliac disease (CD) patients introduce oats their gluten free diet. We sought further data from the clinical setting with regards consumption by patients. Several oat products were tested for wheat contamination using a commercial enzyme linked immunoassay (ELISA) kit, and six samples examined an ELISA cocktail of monoclonal antibodies, mass spectrometry, western blot analysis. Nineteen adult CD on diet challenged 50 g per day 12 weeks. Serological testing...
Celiac disease is a common severe intestinal resulting from intolerance to dietary wheat gluten and related proteins. The large majority of patients expresses the HLA-DQ2 and/or DQ8 molecules, gluten-specific HLA-DQ-restricted T cells have been found at site lesion in gut. nature peptides that are recognized by such cells, however, has unclear so far. We now report identification gliadin-derived epitope dominantly HLA-DQ8-restricted cells. characterization epitopes key step toward...
In celiac disease (CD), gluten induces both adaptive and innate immune responses. Non-celiac sensitivity (NCGS) is another form of intolerance where the response less characterized. The aim our study was to explore compare early mucosal immunological events in CD NCGS.We challenged 30 HLA-DQ2(+) NCGS 15 patients, all on a gluten-free diet, with four slices gluten-containing bread daily for 3 days. Duodenal biopsy specimens were collected before after challenge. examined cytokine mRNA by...
Tetramers of MHC–peptide complexes are used for detection and characterization antigen-specific T cell responses, but they require knowledge about both antigenic peptide the MHC restriction element. The successful application these reagents in human diseases involving CD4 + cells is limited. Celiac disease, an intestinal inflammation driven by mucosal recognizing wheat gluten peptides context disease-associated HLA-DQ molecules, ideal model to test potential clinical use reagents. We...
Common variable immunodeficiency (CVID) is the most common symptomatic primary characterized by low immunoglobulin (Ig)G and IgA, and/or IgM. In addition to bacterial infections, a large subgroup has noninfectious inflammatory autoimmune complications. We performed 16S ribosomal RNA-based profiling of stool samples in 44 CVID patients, 45 patients with bowel disease (disease controls), 263 healthy controls. measured plasma lipopolysaccharide (LPS) markers immune cell activation (i.e.,...