A5059000621- Biosimilars and Bioanalytical Methods
- Rheumatoid Arthritis Research and Therapies
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Inflammatory Bowel Disease
- Chronic Lymphocytic Leukemia Research
- Pharmaceutical studies and practices
- Immunodeficiency and Autoimmune Disorders
- COVID-19 Clinical Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Autoimmune and Inflammatory Disorders Research
- Musculoskeletal pain and rehabilitation
- Spondyloarthritis Studies and Treatments
- Microscopic Colitis
- Heparin-Induced Thrombocytopenia and Thrombosis
- Peripheral Neuropathies and Disorders
- Cancer Immunotherapy and Biomarkers
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Tuberculosis Research and Epidemiology
- Spine and Intervertebral Disc Pathology
- Immunotherapy and Immune Responses
- Pain Mechanisms and Treatments
- Cytokine Signaling Pathways and Interactions
- Liver Disease Diagnosis and Treatment
Diakonhjemmet Hospital
2016-2025
University of Oslo
2023-2024
Institute for Rheumatic Diseases (Japan)
2024
<h3>Objectives:</h3> New effective therapies with particularly good effect on joint destruction have highlighted the need for reliable predictors of radiographic progression in rheumatoid arthritis (RA). Our objective was to assess combined predictive role a set laboratory markers regard 10-year progression, and examine anti-cyclic citrullinated peptide (anti-CCP) level. <h3>Methods:</h3> A cohort 238 patients RA followed longitudinally 10 years collection clinical data serum samples. 125...
<h3>Importance</h3> Proactive therapeutic drug monitoring (TDM), consisting of individualized treatment based on scheduled assessments serum levels, has been proposed as an alternative to standard therapy optimize efficacy and safety infliximab other biologic drugs. However, it remains unclear whether proactive TDM improves clinical outcomes during maintenance therapy. <h3>Objective</h3> To assess with by preventing disease worsening compared without TDM. <h3>Design, Setting,...
<h3>Importance</h3> Proactive therapeutic drug monitoring (TDM), defined as individualized dosing based on scheduled of serum levels, has been proposed an alternative to standard therapy maximize efficacy and safety infliximab other biological drugs. However, whether proactive TDM improves clinical outcomes when implemented at the time initiation, compared with therapy, remains unclear. <h3>Objective</h3> To assess during initiation treatment without TDM. <h3>Design, Setting,...
Objectives: Anti-citrullinated peptide antibodies (ACPAs) are established as useful predictors of radiographic progression in rheumatoid arthritis (RA). The main objective this study was to test the prognostic capacity recently developed for anti-mutated citrullinated vimentin (anti-MCV). Methods: A cohort 238 patients with RA followed longitudinally 10 years; 125 complete x ray sets were included analyses. Radiographs scored according van der Heijde modified Sharp score (SHS). Patients...
The 52-week, randomized, double-blind, noninferiority, government-funded NOR-SWITCH trial demonstrated that switching from infliximab originator to less expensive biosimilar CT-P13 was not inferior continued treatment with originator. extension aimed assess efficacy, safety and immunogenicity in patients on throughout the 78-week study period (maintenance group) versus switched at week 52 (switch group). primary outcome disease worsening during follow-up based disease-specific composite...
Abstract Aims We recently reported five cases of vaccine-induced immune thrombotic thrombocytopenia (VITT) 7–10 days after receiving the first dose ChAdOx1 nCoV-19 adenoviral vector vaccine against corona virus disease 2019 (COVID-19). aimed to investigate pathogenic immunological responses operating in these patients. Methods and results assessed circulating inflammatory markers by assays cell phenotyping flow cytometry analyses performed immunoprecipitation with anti-platelet factor (PF)4...
Objective Immunogenicity and safety following receipt of the standard SARS–CoV‐2 vaccination regimen in patients with immune‐mediated inflammatory diseases (IMIDs) are poorly characterized, data after third vaccine dose lacking. The aim study was to evaluate serologic responses adverse events 2‐dose a IMID receiving immunosuppressive therapy. Methods Adult therapy for rheumatoid arthritis, spondyloarthritis, psoriatic Crohn's disease, or ulcerative colitis, as well healthy adult controls,...
Background The presence of anti-citrullinated protein antibodies (ACPA) is a powerful predictive factor for the development and progression rheumatoid arthritis (RA). ACPA response has been shown to consist various isotypes, but consequences differences in isotype distribution have not extensively investigated. Objective To investigate relationship between disease radiological outcome. Methods isotypes were determined sera anti-cyclic citrullinated peptide 2-positive patients by...
Abstract Background Anti‐drug antibodies (ADAb) frequently form early in the treatment course of infliximab and other tumour necrosis factor (TNF) inhibitors, leading to failure adverse events. Objective To identify risk factors for ADAb phase treatment. Methods Patients ( n = 410) with immune‐mediated inflammatory diseases who initiated were included 38‐week Norwegian Drug Monitoring Trial (NOR‐DRUM) A randomised 1:1 therapeutic drug monitoring (TDM) or standard therapy. Serum levels...
Objectives Humoral vaccine responses to SARS-CoV-2 vaccines are impaired and short lasting in patients with immune-mediated inflammatory diseases (IMID) following two doses. To protect these vulnerable against severe COVID-19 disease, a three-dose primary vaccination strategy has been implemented many countries. The aim of this study was evaluate humoral response safety three doses IMID. Methods Patients IMID on immunosuppressive therapy healthy controls receiving two-dose vaccination,...
Introduction Achieving remission is a critical therapeutic goal in the management of rheumatoid arthritis (RA). Despite methotrexate being cornerstone early RA treatment, significant proportion patients fail to achieve remission. This study aims predict 6-month non-remission 222 disease-modifying anti-rheumatic drug (DMARD)-naïve initiating monotherapy, using baseline patient characteristics from ARCTIC trial. Methods Machine learning models were developed utilizing twenty-one demographic,...
As current predictors of joint destruction have low specificity, serological biomarkers reflecting bone and cartilage been proposed as tools in assessing prognosis rheumatoid arthritis (RA). We examined whether serum concentrations a panel could predict radiographic progression patients with RA.A cohort 238 RA was followed longitudinally for 10 years collection clinical data samples. These analyses focus on the 136 radiographs hands available at baseline 5 and/or years. Radiographs were...
Abstract Background Infliximab (INX) and other tumour necrosis factor inhibitors (TNFi) have revolutionised the treatment of several immune mediated inflammatory diseases. Still, many patients do not respond sufficiently to therapy or lose efficacy over time. The large interindividual variation in serum drug concentrations on standard doses development anti-drug antibodies are thought be major reasons for failures. Therapeutic monitoring (TDM), an individualised strategy based systematic...
To explore associations between serum adalimumab level, treatment response and drug survival in order to identify optimal levels for therapeutic monitoring of adalimumab. Also, assess the occurrence risk factors anti-drug antibody (ADAb) formation.
Objectives To assess incidence, severity and predictors of COVID-19, including protective post-vaccination levels antibodies to the receptor-binding domain SARS-CoV-2 spike protein (anti-RBD), informing further vaccine strategies for patients with immune-mediated inflammatory diseases (IMIDs) on immunosuppressive medication. Methods IMIDs immunosuppressives healthy controls (HC) receiving vaccines were included in this prospective observational study. COVID-19 outcome registered anti-RBD...
To examine associations between a panel of soluble biomarkers and progressive joint destruction assessed by magnetic resonance imaging (MRI) conventional radiographs as well longitudinal with disease activity clinically MRI in early rheumatoid arthritis (RA) patients.84 RA patients were evaluated at baseline, 3, 6 12 months clinical examination, serum urine sampling, scans the dominant wrist hands. A (sCTX-I, uCTX-II, sOPG, sYKL-40, sCOMP sMMP-3) was ELISA. images scored according to score...
Abstract Introduction Prognosis in rheumatoid arthritis (RA) is difficult to assess. The aim of this study was examine whether serum levels a spectrum cytokines were predictive radiographic progression early RA patients. Methods A total 82 patients (disease duration < 1 year) followed for 12 months. Clinical assessments, X-rays hands and magnetic resonance imaging (MRI) the dominant wrist assessed at baseline after 3, 6 scored according van der Heijde modified Sharp score (vdHSS)....
The durability of vaccine-induced humoral immunity against SARS-CoV-2 in patients with immune-mediated inflammatory diseases (IMIDs) on immunosuppressive therapy is not known. aim this study was to compare the persistence anti-Spike antibodies following two-dose vaccination between IMID and healthy controls identify factors associated antibody decline.