A5073458012- Cerebrovascular and Carotid Artery Diseases
- Atherosclerosis and Cardiovascular Diseases
- Acute Ischemic Stroke Management
- Cardiovascular Health and Disease Prevention
- Venous Thromboembolism Diagnosis and Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cerebral Venous Sinus Thrombosis
- Stroke Rehabilitation and Recovery
- Cell Adhesion Molecules Research
- Blood Coagulation and Thrombosis Mechanisms
- Complement system in diseases
- Chemokine receptors and signaling
- Neurological disorders and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammasome and immune disorders
- Peripheral Artery Disease Management
- Protease and Inhibitor Mechanisms
- Lipoproteins and Cardiovascular Health
- Intracranial Aneurysms: Treatment and Complications
- Platelet Disorders and Treatments
- Cardiovascular Disease and Adiposity
- Genetic Neurodegenerative Diseases
- Peroxisome Proliferator-Activated Receptors
- RNA Research and Splicing
- RNA modifications and cancer
Oslo University Hospital
2016-2025
University of Oslo
2014-2025
Institutt for Eksperimentell Medisinsk Forskning
2022
Maastricht University
2015
Nevro (United States)
2014
Aarhus University Hospital
2008
Technische Hochschule Ulm
2008
Although the participation of inflammation in atherogenesis is widely recognized, identification different components has not been clarified. In particular, role plaque destabilization fully understood.Our main findings were as follows: (1) a microarray experiment, we identified visfatin, one most recently adipokines, gene that was markedly enhanced carotid plaques from symptomatic compared with asymptomatic individuals. This finding confirmed when 7 patients and 14 lesions examined...
The cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin facilitates atheroprotective mechanisms through oxysterol-mediated reprogramming of macrophages.
Background The NLR family, pyrin domain containing 3 ( NLRP 3) inflammasome is an interleukin IL )‐1β and ‐18 cytokine processing complex that activated in inflammatory conditions. role of the pathogenesis atherosclerosis myocardial infarction not fully understood. Methods Results Atherosclerotic plaques were analyzed for transcripts inflammasome, ‐1β release. Swedish First‐ever Infarction study Ac‐county FIA ) cohort consisting DNA from 555 patients 1016 healthy individuals was used to...
<h3>Importance</h3> Thrombosis with thrombocytopenia syndrome (TTS) has been reported after vaccination the SARS-CoV-2 vaccines ChAdOx1 nCov-19 (Oxford–AstraZeneca) and Ad26.COV2.S (Janssen/Johnson & Johnson). <h3>Objective</h3> To describe clinical characteristics outcome of patients cerebral venous sinus thrombosis (CVST) without TTS. <h3>Design, Setting, Participants</h3> This cohort study used data from an international registry consecutive CVST within 28 days included between March...
Background Complement activation may promote atherosclerosis. Yet, data on the to which extent complement, and more specifically alternative complement pathway, is activated in patients with carotid atherosclerosis related adverse outcome these patients, are scarce. Methods Results We measured, by ELISA, plasma levels of factor D, properdin, C3bBbP (C3 convertase), H advanced a Discovery (n=324) Validation (n=206) cohort relation (mean follow‐up 7.8 6.6 years, respectively). Our major...
While serum-circulating complement destroys invading pathogens, intracellularly active complement, termed the “complosome,” functions as a vital orchestrator of cell-metabolic events underlying T cell effector responses. Whether intracellular is also nonredundant for activity myeloid immune cells currently unknown. Here, we show that monocytes and macrophages constitutively express component (C) 5 generate autocrine C5a via formation an C5 convertase. Cholesterol crystal sensing by induced...
Background and Purpose- A significant proportion of ischemic strokes are caused by emboli from unstable carotid artery plaques with intraplaque neovascularization (IPN) as a key feature plaque instability. IPN is not detectable conventional Doppler ultrasound. Contrast-enhanced ultrasound (CEUS) can visualize IPN, but its use limited in clinical practice because it requires an intravenous injection contrast. Superb microvascular imaging (SMI) without contrast uses algorithm to remove clutter...
Abstract Aims We recently reported five cases of vaccine-induced immune thrombotic thrombocytopenia (VITT) 7–10 days after receiving the first dose ChAdOx1 nCoV-19 adenoviral vector vaccine against corona virus disease 2019 (COVID-19). aimed to investigate pathogenic immunological responses operating in these patients. Methods and results assessed circulating inflammatory markers by assays cell phenotyping flow cytometry analyses performed immunoprecipitation with anti-platelet factor (PF)4...
The risk for cardiovascular events is related to the composition and stability of an atherosclerotic plaque driven by inflammation deposition lipids. Scavenger receptors are a family cell surface involved in lipid uptake inflammation. Recently, we found that soluble CD36 increased plasma from patients with diabetes strongly correlated insulin resistance.We tested whether marker high-grade internal carotid stenoses (n=62). were classified according symptomatology echogenicity on ultrasound...
Background and Purpose— Interleukin (IL)-23 is a cytokine in the IL-12 family, mainly produced by antigen-presenting cells with central role inflammation. We hypothesize that IL-23 also important atherogenesis investigate this population carotid atherosclerosis. Methods— Plasma levels of were measured patients artery stenosis healthy controls. The mRNA its receptor, IL-23R, atherosclerotic plaques, nonatherosclerotic vessels, peripheral blood mononuclear cells, plasmacytoid dendritic cells....
Background Atherosclerosis is a major cause of cerebrovascular disease. Matrix metalloproteinases (MMPs) play an important role in matrix degradation within the atherosclerotic lesion leading to plaque destabilization and ischemic stroke. We hypothesized that MMP-7 could be involved this process. Methods Plasma levels were measured 182 consecutive patients with moderate (50–69%) or severe (≥70%) internal carotid artery stenosis, 23 healthy controls. The mRNA plaques different symptomatology,...
BackgroundDuring atherogenesis, cholesterol precipitates into crystals (CC) in the vessel wall, which trigger plaque inflammation by activating NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome. We investigated relationship between CC, complement NLRP3 patients with cardiovascular disease.MethodsWe analysed plasma, peripheral blood mononuclear cells (PBMC) carotid plaques from advanced atherosclerosis applying ELISAs, multiplex cytokine assay, qPCR, immunohistochemistry,...
Background and Purpose— Cerebral microembolic signals detected by transcranial Doppler are frequent during carotid angioplasty with stenting endarterectomy (CEA). Their potential harmful effects on the brain are, however, unclear. The aim of this study was to relate frequency type per-procedural procedure-related ipsilateral ischemic strokes new lesions diffusion-weighted cerebral MRI. Methods— Eighty-five patients who were prospectively treated CEA (61) or (30) for high-grade (≥70%)...
Background and Purpose Fatty acid binding protein 4 (FABP4) has been shown to play an important role in macrophage cholesterol trafficking associated inflammation. To further elucidate the of FABP4 atherogenesis humans, we examined regulation carotid atherosclerosis ischemic stroke. Methods We plasma levels asymptomatic (n = 28) symptomatic 31) patients with atherosclerosis, as well 202 subjects acute In a subgroup also analysed expression within atherosclerotic lesion. addition,...
Soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) has been shown to be increased in patients with acute ischemic stroke. Here, we evaluated plasma sLOX-1 levels and vascular carotid plaque LOX-1 (ie, OLR1) gene expression stroke transient attack (TIA) particular focus on their relation time since symptom onset.Plasma (n=232) OLR1 (n=146) were who referred evaluation for endarterectomy, as well healthy control (n=81). Patients categorized according presence of or (n=35)...
More than 170 post-transcriptional RNA modifications regulate the localization, processing and function of cellular RNAs, aberrant have been linked to a range human diseases. The modification landscape in atherosclerosis, main underlying cause cardiovascular diseases, is still largely unknown.We used mass spectrometry analyse selection RNA-modifying enzymes N6-methyladenosine (m6A) carotid atherosclerotic lesion samples representing early advanced stages atherosclerosis as compared...
During a 2-week period, we have encountered five cases presenting with the combination of cerebral venous thrombosis (CVT), intracerebral hemorrhage and thrombocytopenia. A clinical hallmark was rapid severe progression disease in spite maximum treatment efforts, resulting fatal outcome for 4 out 5 patients. All had received ChAdOx1 nCov-19 vaccine 1–2 weeks earlier developed characteristic syndrome thereafter. The progressive course high fatality rate CVT thrombocytopenia such cluster...