Richard H. Swartz
A5115600457- Acute Ischemic Stroke Management
- Dementia and Cognitive Impairment Research
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Alzheimer's disease research and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Disease Mechanisms and Treatments
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disorders and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Obstructive Sleep Apnea Research
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Amyotrophic Lateral Sclerosis Research
- Cerebral Palsy and Movement Disorders
- Blood Pressure and Hypertension Studies
- Cardiovascular and Diving-Related Complications
- Eicosanoids and Hypertension Pharmacology
- Restless Legs Syndrome Research
- Neurobiology of Language and Bilingualism
- Sleep and Wakefulness Research
- Neurological Complications and Syndromes
Sunnybrook Health Science Centre
2016-2025
University of Toronto
2016-2025
Health Sciences Centre
2016-2025
Sunnybrook Research Institute
2016-2025
Ontario Stroke Network
2011-2025
Institute for Clinical Evaluative Sciences
2011-2024
University of Calgary
2013-2024
McMaster University
2013-2024
Sunnybrook Hospital
2011-2024
Ontario Brain Institute
2016-2024
Among patients with a proximal vessel occlusion in the anterior circulation, 60 to 80% of die within 90 days after stroke onset or do not regain functional independence despite alteplase treatment. We evaluated rapid endovascular treatment addition standard care acute ischemic small infarct core, intracranial arterial occlusion, and moderate-to-good collateral circulation.We randomly assigned participants receive (control group) plus use available thrombectomy devices (intervention group)....
The 2019 update of the Canadian Stroke Best Practice Recommendations (CSBPR) for Mood, Cognition and Fatigue following is a comprehensive set evidence-based guidelines addressing three important issues that can negatively impact lives people who have had stroke. These include post-stroke depression anxiety, vascular cognitive impairment, fatigue. Following stroke, approximately 20% to 50% all persons may be affected by at least one these conditions. There also overlap between conditions,...
OBJECTIVE Type 2 diabetes (T2D) increases dementia risk, but clear evidence to recommend interventions that can mitigate risk remains lacking. This population-based retrospective cohort study aimed determine whether new use of sodium–glucose cotransporter (SGLT2) inhibitors compared with dipeptidyl peptidase 4 (DPP-4) was associated lower risk. RESEARCH DESIGN AND METHODS Ontario residents aged ≥66 years who were users an SGLT2 inhibitor or a DPP-4 from 1 July 2016 31 March 2021 entered the...
BackgroundWhether the large effect size of endovascular thrombectomy (EVT) for stroke due to large-vessel occlusion applies medium-vessel is unclear.MethodsIn a multicenter, prospective, randomized, open-label trial with blinded outcome evaluation, we assigned patients acute ischemic who presented within 12 hours from time that they were last known be well and had favorable baseline noninvasive brain imaging receive EVT plus usual care or alone. The primary was modified Rankin scale score...
Prospective differentiation between reversible cerebral vasoconstriction syndrome and central nervous system vasculitis can be challenging. We hypothesized that high-resolution vessel wall MRI would demonstrate arterial enhancement in but not syndrome.We identified all patients with multifocal segmental narrowing of large intracranial arteries who had follow-up angiography at our institute over a 4-year period performed detailed chart review.Three lacked enhancement, these reversal within 3...
Functional outcome after stroke is often only evaluated using the modified Rankin Scale, which primarily assesses activities of daily living. Stroke patients may experience difficulties with social reintegration and mental functions, feel isolated, poor quality life, even physical recovery complete. assessments based solely on activity limitations not be able to capture full range problems experienced by survivors.Telephone interviews were conducted 2 3 years poststroke assess multiple...
Every year, approximately 62 000 people with stroke and transient ischemic attack are treated in Canadian hospitals, the evidence suggests one-third or more will experience vascular-cognitive impairment, and/or intractable fatigue, either alone combination. The 2015 update of Stroke Best Practice Recommendations: Mood, Cognition Fatigue Module guideline is a comprehensive summary current evidence-based recommendations for clinicians range settings, who provide care to patients following...
To test the hypothesis that enlarged Virchow-Robin space volumes (VRS) are associated with objective measures of poor quality sleep. Retrospective cross-sectional study. Sunnybrook Health Sciences Centre. Twenty-six patients being evaluated for cerebrovascular disease were assessed using polysomnography and high-resolution structural magnetic resonance imaging. Regionalized VRS quantified from three-dimensional imaging correlated polysomnography-derived sleep parameters while controlling...
Abstract Because individuals develop dementia as a manifestation of neurodegenerative or neurovascular disorder, there is need to reliable approaches their identification. We are undertaking an observational study (Ontario Neurodegenerative Disease Research Initiative [ONDRI]) that includes genomics, neuroimaging, and assessments cognition well language, speech, gait, retinal imaging, eye tracking. Disorders studied include Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal...
Intracerebral hemorrhage (ICH) is a devastating stroke type that lacks effective treatments. An imaging biomarker of ICH expansion-the computed tomography (CT) angiography spot sign-may identify subgroup could benefit from hemostatic therapy.To investigate whether recombinant activated coagulation factor VII (rFVIIa) reduces expansion among patients with sign-positive ICH.In parallel investigator-initiated, multicenter, double-blind, placebo-controlled randomized clinical trials in Canada...
Background: Rural residence is associated with stroke incidence and mortality, but little known about potential rural/urban differences in ambulatory care. Methods Results: We used the CANHEART (Cardiovascular Health Ambulatory Care Research Team) cohort, created from linked administrative databases province of Ontario, Canada, divided into primary (N=6 207 032) secondary (N=75 823) prevention cohorts based on absence or presence prior stroke. defined rural communities as those a population...
Early treatment of patients with transient ischemic attack (TIA) reduces the risk stroke. However, many present symptoms that have an uncertain diagnosis. Patients motor, speech, or prolonged are at highest for recurrent stroke and most likely to undergo comprehensive investigations. Lower-risk much more be cursorily investigated.To establish frequency acute infarct defined by diffusion restriction detected on diffusion-weighted imaging (DWI) magnetic resonance (MRI) scan (DWI positive).The...