Axel Rohr

ORCID: 0000-0003-4684-7920
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Acute Ischemic Stroke Management
  • Cerebrovascular and Carotid Artery Diseases
  • Advanced MRI Techniques and Applications
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Neurosurgical Procedures and Complications
  • Stroke Rehabilitation and Recovery
  • Glioma Diagnosis and Treatment
  • Epilepsy research and treatment
  • Intracranial Aneurysms: Treatment and Complications
  • Cerebral Venous Sinus Thrombosis
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Meningioma and schwannoma management
  • Memory and Neural Mechanisms
  • Neuroscience and Neuropharmacology Research
  • Venous Thromboembolism Diagnosis and Management
  • Parkinson's Disease and Spinal Disorders
  • Regulation of Appetite and Obesity
  • Neurological disorders and treatments
  • Peripheral Artery Disease Management
  • Anesthesia and Neurotoxicity Research
  • Infectious Encephalopathies and Encephalitis
  • Advanced X-ray and CT Imaging
  • Parkinson's Disease Mechanisms and Treatments
  • MRI in cancer diagnosis
  • Vascular Malformations Diagnosis and Treatment

Vancouver General Hospital
2017-2025

Humanitas University
2024

University of British Columbia
2017-2024

University of Calgary
2024

IRCCS Humanitas Research Hospital
2024

United Nations Economic and Social Commission for Asia and the Pacific
2021-2024

Health and Education Research Management and Epidemiologic Services (United States)
2023

Kiel University
2004-2020

University of Lübeck
2009-2019

University Hospital Schleswig-Holstein
2009-2019

Michael D. Hill Mayank Goyal Bijoy K. Menon Raul G. Nogueira Ryan McTaggart and 95 more Andrew M. Demchuk Alexandre Y. Poppe Brian Buck Thalia S. Field Dar Dowlatshahi Brian van Adel Richard H. Swartz Ruchir Shah Eric Sauvageau Charlotte Zerna Johanna M. Ospel Manish Joshi Mohammed Almekhlafi Karla J. Ryckborst Mark Lowerison Kathy Heard David Garman Diogo C Haussen Shawna M Cutting Shelagh B. Coutts Daniel Roy Jeremy Rempel Axel Rohr Daniela Iancu Demetrios J. Sahlas Amy Yu Thomas Devlin Ricardó A. Hanel Volker Puetz Frank L. Silver Bruce Campbell René Chapot Jeanne Teitelbaum Jennifer Mandzia Timothy Kleinig David Turkel‐Parrella Donald Heck Michael Kelly Aditya Bharatha Oh Young Bang Ashutosh P. Jadhav Rishi Gupta Donald Frei Jason Tarpley Cameron McDougall Staffan Holmin Joung‐Ho Rha Ajit S Puri Marie‐Christine Camden Götz Thomalla Hana Choe Stephen Phillips Joseph Schindler John Thornton Simon Nagel Ji Hoe Heo Sung‐Il Sohn Marios‐Nikos Psychogios Ronald F. Budzik Sidney Starkman Coleman Martin Paul Burns Seán Murphy George Α. Lopez Joey English Michael Tymianski Andrew M. Demchuk Philip A. Barber Eric E. Smith Simerpreet Bal Suresh Subramaniam Steven Peters P Couillard Gary Klein Peter K. Stys Bijoy K. Menon Shelagh B. Coutts Mohammed Almekhlafi Michael D. Hill Mayank Goyal John Wong Alim P. Mitha Muneer Eesa William Morrish Saad Alqatani Nima Kashani Manish Joshi Charlotte Zerna Johanna M. Ospel Prasanna Venkatesan Erika Teleg Amith Sitaram Brett Graham Stephen van Gaal Aimen Moussaddy

10.1016/s0140-6736(20)30258-0 article EN The Lancet 2020-02-21

<b>Objective</b> To evaluate the effect of different treatment strategies on enterohaemorrhagic <i>Escherichia coli</i> O104:H4 induced haemolytic uraemic syndrome. <b>Design</b> Multicentre retrospective case-control study. <b>Setting</b> 23 hospitals in northern Germany. <b>Participants</b> 298 adults with <i>E <b>Main outcome measures</b> Dialysis, seizures, mechanical ventilation, abdominal surgery owing to perforation bowel or necrosis, and death. <b>Results</b> 160 patients (54%)...

10.1136/bmj.e4565 article EN cc-by-nc BMJ 2012-07-19

Autobiographical memories in our lives are critically dependent on temporal lobe structures. However, the contribution of CA1 neurons human hippocampus to retrieval episodic autobiographical memory remains elusive. In patients with a rare acute transient global amnesia, highly focal lesions confined field can be detected MRI. We studied effect these using detailed interview including remember/know procedure. 14 16 patients, sector hippocampal cornu ammonis were detected. was significantly...

10.1073/pnas.1110266108 article EN Proceedings of the National Academy of Sciences 2011-10-10

The aetiology, pathomechanisms and anatomical correlates of transient global amnesia (TGA) still remain obscure. Recently, focal MR-signal diffusion-weighted imaging (DWI) changes in the hippocampus have been described patients with TGA, but exact localization, long term outcome pathophysiological nature these lesions unknown. topography time course hippocampal DWI 41 TGA was studied using serial 3 T high-resolution MR-imaging correlated to clinical neuropsychometric results. Of these, 29...

10.1093/brain/awl248 article EN Brain 2006-09-26

Summary Encephalitis is generally presumed, even when seizures follow banal febrile infection, and pathogen detection in cerebrospinal fluid fails. This retrospective multicenter case series reports on 22 previously healthy children aged 3–15 years (median 6.5 years) with prolonged or recurrent occurring 2–14 days 5 days) after fever onset (19 respiratory nonspecific infections). Cerebrospinal studies revealed 2–42 cells/μl cells/μl) no pathogens. Electroencephalography showed diffuse...

10.1111/j.1528-1167.2010.02535.x article EN Epilepsia 2010-03-20

We sought to evaluate how accurately length and volume of thrombotic clots occluding cerebral arteries patients with acute ischemic stroke can be assessed from nonenhanced CT (NECT) scans reconstructed different slice widths.NECT image data 58 vascular occlusion proven by angiography were widths 1.25 mm, 2.5 3.75 5 mm. Thrombus lengths volumes quantified based on these NECT images detecting segmenting intra-arterial hyperdensities. The results compared reference values thrombus obtained...

10.1161/strokeaha.110.580662 article EN Stroke 2010-07-02

Obesity is associated with hypothalamic inflammation (HI) in animal models. In the current study, we examined mediobasal hypothalamus (MBH) of 57 obese human subjects and 54 age- sex- matched nonobese control by MRI analyzed T2 hyperintensity as a measure HI. Obese exhibited left but not right MBH, which was strongly systemic low-grade inflammation. MRS revealed number neurons region to be similar versus subjects, suggesting functional structural impairment due inflammatory process. To gain...

10.2337/db17-0067 article EN Diabetes 2017-06-02

The CA1 (cornu ammonis) region of hippocampus is selectively vulnerable to a variety metabolic and cytotoxic insults, which mirrored in delayed neuronal death neurons. basis mechanisms this regional susceptibility neurons are poorly understood, the correlates human diseases affecting not clear. Adopting translational approach, lesion evolution, temporal course, pattern diffusion changes, damage hippocampal acute neurologic disorders were studied using high-resolution magnetic resonance...

10.1038/jcbfm.2015.137 article EN Journal of Cerebral Blood Flow & Metabolism 2015-06-17

The objective of our study was to describe the clinical features camptocormia, an involuntary, marked flexion thoracolumbar spine in idiopathic Parkinson's disease (PD) and understand its etiology. In a prospective, cross-sectional study, we examined 15 patients with PD camptocormia using laboratory parameters, EMG, muscle magnetic resonance imaging, biopsy paravertebral muscles. data were compared matched control group without biopsies muscles from age-matched autopsies. Almost all (median...

10.1002/mds.22780 article EN Movement Disorders 2010-01-27

Febrile infection-related epilepsy syndrome (FIRES) is a severe postinfectious epileptic encephalopathy in previously healthy children and has three phases: the initial phase with simple febrile infection, few days later acute characterized by peracute onset of highly recurrent seizures or refractory status epilepticus often no more fever generally without additional neurological features (the classical pure seizure phenotype), last, chronic drug-resistant neuropsychological impairments....

10.1055/s-0032-1323848 article EN Neuropediatrics 2012-08-01

Purpose The aim of this study was to determine whether dual-energy computed tomography (DECT) imaging is superior conventional noncontrast (CT) for the detection acute ischemic stroke. Materials and Methods This a retrospective, single-center 40 patients who presented emergency department (ED) major, care, teaching center with signs symptoms Only those ED within 4 hours symptom onset were included in study. All received DECT head at time presentation. Each patient also standard CT 24 after...

10.1097/rli.0000000000000413 article EN Investigative Radiology 2017-09-15

Collateral blood supply is a key determinant of outcome in large-vessel occlusion acute ischemic stroke. Single- and multiphase CTA collateral scoring systems have been described but are subjective require training. We aimed to test whether the CTP-derived hypoperfusion intensity ratio associated with status threshold exists that predicts poor collaterals.Imaging clinical data consecutive patients stroke were retrospectively reviewed. Single-phase performed by 2 blinded neuroradiologists...

10.3174/ajnr.a7181 article EN cc-by American Journal of Neuroradiology 2021-06-17

Background The effect of infarct pattern on functional outcome in acute ischemic stroke is incompletely understood. Purpose To investigate the association qualitative and quantitative variables at 24-hour follow-up noncontrast CT diffusion-weighted MRI with 90-day clinical outcome. Materials Methods Safety Efficacy Nerinetide Subjects Undergoing Endovascular Thrombectomy for Stroke, or ESCAPE-NA1, randomized controlled trial enrolled patients large-vessel-occlusion undergoing mechanical...

10.1148/radiol.2021203964 article EN Radiology 2021-05-11

Summary Purpose: Ninety percent of patients with tuberous sclerosis complex (TSC) have epilepsy. Identification epileptogenic areas can be difficult and studies are needed to characterize the network in more detail. Methods: Five children TSC focal epilepsy were studied using simultaneous EEG functional MRI recordings. Tubers marked by a neuroradiologist on anatomical MRI. Spike‐associated BOLD (blood oxygenation level‐dependent) responses superimposed lesions. Results: Thirteen different...

10.1111/j.1528-1167.2007.01486.x article EN Epilepsia 2008-02-07

<h3>BACKGROUND AND PURPOSE:</h3> IH can alter the configuration of anatomic structures central nervous system. We determined sensitivity and specificity MR imaging to detect these changes in patients with secondary IH. <h3>MATERIALS METHODS:</h3> Patients (<i>n</i> = 36) were prospectively investigated matched 36 controls. images evaluated for elongation edema optic nerves, protrusion disc, flattening posterior sclera, height pituitary gland, width nerve sheath. On MRV, we recorded venous...

10.3174/ajnr.a2463 article EN cc-by American Journal of Neuroradiology 2011-04-21

Craniospinal hyper- or hypotension leads to morphologic changes in certain intracranial structures. We tested the hypothesis that amount of CSF ONS visible MR imaging is reduced patients with CSH.Nineteen CSH were prospectively studied. Three readers assessed width peri-optical rim at 4 different anatomic positions by using coronal STIR sequences from a 3T scanner. The height pituitary gland was also measured. Results compared normal values obtained same technique. Qualitative signs recorded...

10.3174/ajnr.a2120 article EN cc-by American Journal of Neuroradiology 2010-06-03

The pathomechanisms of transient global amnesia (TGA) remain enigmatic. Focal MR signal diffusion changes in the CA-1 sector hippocampus have been described amnesia, but pathophysiologic correlate these lesions is unknown.We studied metabolic spectra seven patients with TGA using spectroscopy (MRS) between 24 and 72 hours after onset 2 to 5 months later. amnestic deficit was a neuropsychometric test battery.Four out an acute showed lesion corresponding T2 hippocampus. Selective hippocampal...

10.1212/01.wnl.0000306633.06027.33 article EN Neurology 2008-03-24

<h3>BACKGROUND AND PURPOSE:</h3> Brain parenchymal hyperdensity on postthrombectomy CT in patients with acute stroke can be due to hemorrhage and/or contrast staining. We aimed determine whether iodine concentration within contrast-stained parenchyma compared an internal reference the superior sagittal sinus dual-energy could predict subsequent intracerebral hemorrhage. <h3>MATERIALS METHODS:</h3> Seventy-one small infarct cores (ASPECTS ≥ 7) and good endovascular recanalization (modified...

10.3174/ajnr.a6345 article EN cc-by American Journal of Neuroradiology 2020-01-01

CT perfusion (CTP) maps can estimate the ischemic core in acute stroke based on distinctive cerebral blood flow thresholds. However, metabolic factors beyond influence tissue tolerance to ischemia and infarct growth rate. Underestimating volume (ICV) might result overestimating salvageable and, consequently, potential clinical benefits of reperfusion therapies. We aim evaluate whether baseline hemoglobin glucose levels accuracy CTP ICV estimations.

10.1212/wnl.0000000000209939 article EN Neurology 2024-10-21
Coming Soon ...