A5072398131- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Stroke Rehabilitation and Recovery
- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Intracranial Aneurysms: Treatment and Complications
- Cerebral Venous Sinus Thrombosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Meningioma and schwannoma management
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Venous Thromboembolism Diagnosis and Management
- Parkinson's Disease and Spinal Disorders
- Regulation of Appetite and Obesity
- Neurological disorders and treatments
- Peripheral Artery Disease Management
- Anesthesia and Neurotoxicity Research
- Infectious Encephalopathies and Encephalitis
- Advanced X-ray and CT Imaging
- Parkinson's Disease Mechanisms and Treatments
- MRI in cancer diagnosis
- Vascular Malformations Diagnosis and Treatment
Vancouver General Hospital
2017-2025
Humanitas University
2024
University of British Columbia
2017-2024
University of Calgary
2024
IRCCS Humanitas Research Hospital
2024
United Nations Economic and Social Commission for Asia and the Pacific
2021-2024
Health and Education Research Management and Epidemiologic Services (United States)
2023
Kiel University
2004-2020
University of Lübeck
2009-2019
University Hospital Schleswig-Holstein
2009-2019
<b>Objective</b> To evaluate the effect of different treatment strategies on enterohaemorrhagic <i>Escherichia coli</i> O104:H4 induced haemolytic uraemic syndrome. <b>Design</b> Multicentre retrospective case-control study. <b>Setting</b> 23 hospitals in northern Germany. <b>Participants</b> 298 adults with <i>E <b>Main outcome measures</b> Dialysis, seizures, mechanical ventilation, abdominal surgery owing to perforation bowel or necrosis, and death. <b>Results</b> 160 patients (54%)...
Autobiographical memories in our lives are critically dependent on temporal lobe structures. However, the contribution of CA1 neurons human hippocampus to retrieval episodic autobiographical memory remains elusive. In patients with a rare acute transient global amnesia, highly focal lesions confined field can be detected MRI. We studied effect these using detailed interview including remember/know procedure. 14 16 patients, sector hippocampal cornu ammonis were detected. was significantly...
The aetiology, pathomechanisms and anatomical correlates of transient global amnesia (TGA) still remain obscure. Recently, focal MR-signal diffusion-weighted imaging (DWI) changes in the hippocampus have been described patients with TGA, but exact localization, long term outcome pathophysiological nature these lesions unknown. topography time course hippocampal DWI 41 TGA was studied using serial 3 T high-resolution MR-imaging correlated to clinical neuropsychometric results. Of these, 29...
Summary Encephalitis is generally presumed, even when seizures follow banal febrile infection, and pathogen detection in cerebrospinal fluid fails. This retrospective multicenter case series reports on 22 previously healthy children aged 3–15 years (median 6.5 years) with prolonged or recurrent occurring 2–14 days 5 days) after fever onset (19 respiratory nonspecific infections). Cerebrospinal studies revealed 2–42 cells/μl cells/μl) no pathogens. Electroencephalography showed diffuse...
We sought to evaluate how accurately length and volume of thrombotic clots occluding cerebral arteries patients with acute ischemic stroke can be assessed from nonenhanced CT (NECT) scans reconstructed different slice widths.NECT image data 58 vascular occlusion proven by angiography were widths 1.25 mm, 2.5 3.75 5 mm. Thrombus lengths volumes quantified based on these NECT images detecting segmenting intra-arterial hyperdensities. The results compared reference values thrombus obtained...
Obesity is associated with hypothalamic inflammation (HI) in animal models. In the current study, we examined mediobasal hypothalamus (MBH) of 57 obese human subjects and 54 age- sex- matched nonobese control by MRI analyzed T2 hyperintensity as a measure HI. Obese exhibited left but not right MBH, which was strongly systemic low-grade inflammation. MRS revealed number neurons region to be similar versus subjects, suggesting functional structural impairment due inflammatory process. To gain...
The CA1 (cornu ammonis) region of hippocampus is selectively vulnerable to a variety metabolic and cytotoxic insults, which mirrored in delayed neuronal death neurons. basis mechanisms this regional susceptibility neurons are poorly understood, the correlates human diseases affecting not clear. Adopting translational approach, lesion evolution, temporal course, pattern diffusion changes, damage hippocampal acute neurologic disorders were studied using high-resolution magnetic resonance...
The objective of our study was to describe the clinical features camptocormia, an involuntary, marked flexion thoracolumbar spine in idiopathic Parkinson's disease (PD) and understand its etiology. In a prospective, cross-sectional study, we examined 15 patients with PD camptocormia using laboratory parameters, EMG, muscle magnetic resonance imaging, biopsy paravertebral muscles. data were compared matched control group without biopsies muscles from age-matched autopsies. Almost all (median...
Febrile infection-related epilepsy syndrome (FIRES) is a severe postinfectious epileptic encephalopathy in previously healthy children and has three phases: the initial phase with simple febrile infection, few days later acute characterized by peracute onset of highly recurrent seizures or refractory status epilepticus often no more fever generally without additional neurological features (the classical pure seizure phenotype), last, chronic drug-resistant neuropsychological impairments....
Purpose The aim of this study was to determine whether dual-energy computed tomography (DECT) imaging is superior conventional noncontrast (CT) for the detection acute ischemic stroke. Materials and Methods This a retrospective, single-center 40 patients who presented emergency department (ED) major, care, teaching center with signs symptoms Only those ED within 4 hours symptom onset were included in study. All received DECT head at time presentation. Each patient also standard CT 24 after...
Collateral blood supply is a key determinant of outcome in large-vessel occlusion acute ischemic stroke. Single- and multiphase CTA collateral scoring systems have been described but are subjective require training. We aimed to test whether the CTP-derived hypoperfusion intensity ratio associated with status threshold exists that predicts poor collaterals.Imaging clinical data consecutive patients stroke were retrospectively reviewed. Single-phase performed by 2 blinded neuroradiologists...
Background The effect of infarct pattern on functional outcome in acute ischemic stroke is incompletely understood. Purpose To investigate the association qualitative and quantitative variables at 24-hour follow-up noncontrast CT diffusion-weighted MRI with 90-day clinical outcome. Materials Methods Safety Efficacy Nerinetide Subjects Undergoing Endovascular Thrombectomy for Stroke, or ESCAPE-NA1, randomized controlled trial enrolled patients large-vessel-occlusion undergoing mechanical...
Summary Purpose: Ninety percent of patients with tuberous sclerosis complex (TSC) have epilepsy. Identification epileptogenic areas can be difficult and studies are needed to characterize the network in more detail. Methods: Five children TSC focal epilepsy were studied using simultaneous EEG functional MRI recordings. Tubers marked by a neuroradiologist on anatomical MRI. Spike‐associated BOLD (blood oxygenation level‐dependent) responses superimposed lesions. Results: Thirteen different...
<h3>BACKGROUND AND PURPOSE:</h3> IH can alter the configuration of anatomic structures central nervous system. We determined sensitivity and specificity MR imaging to detect these changes in patients with secondary IH. <h3>MATERIALS METHODS:</h3> Patients (<i>n</i> = 36) were prospectively investigated matched 36 controls. images evaluated for elongation edema optic nerves, protrusion disc, flattening posterior sclera, height pituitary gland, width nerve sheath. On MRV, we recorded venous...
Craniospinal hyper- or hypotension leads to morphologic changes in certain intracranial structures. We tested the hypothesis that amount of CSF ONS visible MR imaging is reduced patients with CSH.Nineteen CSH were prospectively studied. Three readers assessed width peri-optical rim at 4 different anatomic positions by using coronal STIR sequences from a 3T scanner. The height pituitary gland was also measured. Results compared normal values obtained same technique. Qualitative signs recorded...
The pathomechanisms of transient global amnesia (TGA) remain enigmatic. Focal MR signal diffusion changes in the CA-1 sector hippocampus have been described amnesia, but pathophysiologic correlate these lesions is unknown.We studied metabolic spectra seven patients with TGA using spectroscopy (MRS) between 24 and 72 hours after onset 2 to 5 months later. amnestic deficit was a neuropsychometric test battery.Four out an acute showed lesion corresponding T2 hippocampus. Selective hippocampal...
<h3>BACKGROUND AND PURPOSE:</h3> Brain parenchymal hyperdensity on postthrombectomy CT in patients with acute stroke can be due to hemorrhage and/or contrast staining. We aimed determine whether iodine concentration within contrast-stained parenchyma compared an internal reference the superior sagittal sinus dual-energy could predict subsequent intracerebral hemorrhage. <h3>MATERIALS METHODS:</h3> Seventy-one small infarct cores (ASPECTS ≥ 7) and good endovascular recanalization (modified...
CT perfusion (CTP) maps can estimate the ischemic core in acute stroke based on distinctive cerebral blood flow thresholds. However, metabolic factors beyond influence tissue tolerance to ischemia and infarct growth rate. Underestimating volume (ICV) might result overestimating salvageable and, consequently, potential clinical benefits of reperfusion therapies. We aim evaluate whether baseline hemoglobin glucose levels accuracy CTP ICV estimations.