A5054588035- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- EEG and Brain-Computer Interfaces
- Motor Control and Adaptation
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Parkinson's Disease and Spinal Disorders
- Genetic Neurodegenerative Diseases
- Muscle activation and electromyography studies
- Sexual function and dysfunction studies
- Neural dynamics and brain function
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Neural and Behavioral Psychology Studies
- Glycogen Storage Diseases and Myoclonus
- Vestibular and auditory disorders
- Advanced MRI Techniques and Applications
- Neurological and metabolic disorders
- Optical Imaging and Spectroscopy Techniques
- Evolutionary Psychology and Human Behavior
- Hypothalamic control of reproductive hormones
- Pain Mechanisms and Treatments
- Sleep and Wakefulness Research
University Hospital Schleswig-Holstein
2015-2024
University of Lübeck
2015-2024
Kiel University
2014-2023
Hertie Institute for Clinical Brain Research
2020
German Center for Neurodegenerative Diseases
2020
Janssen (United States)
2020
Clinical Research Center Kiel
2008-2018
Klinik und Poliklinik für Neurologie
2017
Summary Purpose: In patients with idiopathic generalized epilepsy (IGE), blood oxygen level dependent (BOLD) EEG during functional MRI (EEG‐fMRI) has been successfully used to link changes in regional neuronal activity the occurrence of spike‐and‐wave (GSW) discharges. Most EEG‐fMRI studies have performed on adult long‐standing who were antiepileptic medication. Here, we applied investigate BOLD signal absence seizures children newly diagnosed childhood (CAE). Methods: Ten drug‐naive CAE...
Deep brain stimulation of the subthalamic nucleus improves motor functions in patients suffering from advanced Parkinson's disease but some patients, it is also associated with a mild decline cognitive functioning about one standard deviation preoperative state. We assessed impact cortical lead entry point, subcortical electrode path and position active contacts on neuropsychological changes after nucleus–deep compared to control group receiving best medical treatment. Sixty-eight were...
Recent research indicates that physiotherapy can improve motor performance of patients with cerebellar degeneration. Given the known contributions cerebellum to learning, it remains unclear whether such observable changes in are mediated by or cerebral brain areas involved control and learning. The current study addressed this question assessing increase gray matter volume due sensorimotor training using voxel-based morphometry. Nineteen human subjects pure degeneration matched healthy...
Focal hand dystonia has been associated with morphometric changes and distorted somatotopic representations in the putamen.The authors used voxel-based morphometry (VBM) to identify regions putamen where grey-matter volume is musician's (MD) or skill level of piano playing professional pianists.In 11 pianists MD affecting right 12 healthy without dystonia, performed high-resolution T1-weighted MRI brain. The also measured temporal variability key strokes during scale characterise individual...
The ability to discard a prepared action plan in favor of an alternative is critical when facing sudden environmental changes. We tested whether the functional contribution left supramarginal gyrus (SMG) during reprogramming depends on integrity dorsal premotor cortex (PMd). Adopting dual-site repetitive transcranial magnetic stimulation (rTMS) strategy, we first transiently disrupted PMd with “off-line” 1 Hz rTMS and then applied focal “on-line” SMG while human subjects performed spatially...
Is sexual orientation associated with structural differences in the brain? To address this question, 80 homosexual and heterosexual men women (16 15 women) underwent MRI. We used voxel-based morphometry to test for grey matter concentration gender orientation. Compared women, displayed less bilaterally temporo-basal cortex, ventral cerebellum, left premotor cortex. The relative decrease was most prominent perirhinal area also showed than women. Thus, cortex a more male-like pattern. This is...
Background. Hypokinetic dysarthria is highly prevalent in idiopathic Parkinson disease (PD), and effectiveness of high-intensity voice treatment well established. However, the neural correlates remain largely unknown. Objective. We aimed to specify cerebral pathophysiology hypokinetic treatment-induced changes using functional magnetic resonance imaging (fMRI). Methods. used fMRI investigate healthy controls (HCs) patients with PD–associated before after according Lee Silverman Voice...
Cognitive impairment is among the most burdensome non-motor symptoms in Parkinson's disease (PD) and has been associated with hippocampal atrophy. Exercise reported to enhance neuroplasticity hippocampus correlation an improvement of cognitive function. We present data from Training-PD study, which was designed evaluate effects "" training protocol on neuronal plasticity PD.We initiated a 6-week exergaming program, combining visually stimulating computer games physical exercise 17 PD...
In a photosensitive patient intermittent photic stimulation (IPS) accidentally provoked generalized tonic-clonic seizure during simultaneous recordings of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI). Before onset, IPS consistently induced photoparoxysmal responses (PPRs). These PPRs were associated with increases in blood oxygen level dependent (BOLD) signal the visual cortex, thalamus, both superior colliculi, decrease BOLD frontoparietal areas. The cortex...
Writer's cramp (WC) is a focal task-specific dystonia characterized by sustained or intermittent muscle contractions while writing, particularly with the dominant hand. Since structural lesions rarely cause WC, it has been assumed that disease might be caused functional maladaptation within sensory-motor system. Therefore, our objective was to examine differences between patients suffering from WC and healthy control (HC) group regard effective connectivity describes causal influences one...
Clinical key aspects of camptocormia in patients with idiopathic Parkinson's disease (PD) await further definition.Based on a self-assessment PD patients, we performed an observational study, asking subjectively felt involuntary forward bending to return questionnaire and provide photographs showing their axial disorder. Forty-two matched without subjective signs were recruited as controls.The stooped posture advanced is characterized by angle always less than 30 degrees. Of the 145 our 70%...
Abstract Introduction The pathophysiology of writer's cramp, a task‐specific dystonia, remains unclear. objective this study was to investigate the basal ganglia circuit and cerebellum during complex motor sequence learning task carried out with nonaffected hand in cramp patients. Methods We applied structural functional imaging 22 patients 28 matched controls using 3T MRI . With asymptomatic left all participants learned complex, sequential, five‐element sequence‐tapping as accurately...
Motor and cognitive deficits consequently mobility problems are common in geriatric patients. The currently available methods for diagnosis the evaluation of treatment this vulnerable cohort limited. aims ComOn (COgnitive interactions Older populatioN) study (i) to define quantitative markers with clinical relevance motor deficits, (ii) investigate interaction between both (iii) assess health status as well outcome 1000 inpatients hospitals Kiel (Germany), Brescia (Italy), Porto (Portugal),...
Abstract Background Subthalamic nucleus deep brain stimulation (STN‐DBS) effectively treats motor symptoms and quality of life (QoL) advanced fluctuating early Parkinson's disease. Little is known about the relation between electrode position changes in symptom control ultimately QoL. Objectives The stimulated part STN clinical outcomes, including score Unified Disease Rating Scale (UPDRS) quality‐of‐life questionnaire, was assessed a subcohort EARLYSTIM study. Methods Sixty‐nine patients...