A5043201732- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Adipokines, Inflammation, and Metabolic Diseases
- Cell Adhesion Molecules Research
- Coronary Interventions and Diagnostics
- Protease and Inhibitor Mechanisms
- Inflammasome and immune disorders
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Cardiac Fibrosis and Remodeling
- Cancer, Lipids, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Coagulation and Thrombosis Mechanisms
- Acute Myocardial Infarction Research
- Cardiovascular Disease and Adiposity
- Immune Response and Inflammation
- Eicosanoids and Hypertension Pharmacology
- Acute Myeloid Leukemia Research
- Fatty Acid Research and Health
- Aortic aneurysm repair treatments
- Chemokine receptors and signaling
- Antiplatelet Therapy and Cardiovascular Diseases
- Immune Cell Function and Interaction
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
Massachusetts General Hospital
2009-2024
Royal Perth Hospital
2024
Broad Institute
2018-2024
Universidade de São Paulo
2002-2024
University of New Hampshire
2022-2024
The University of Western Australia
2024
Hospital Israelita Albert Einstein
2024
The University of Sydney
2024
Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein predict cardiovascular events. Since statins lower as well cholesterol, we hypothesized that people with elevated but without hyperlipidemia might benefit from statin treatment.
Previous studies have shown that statin therapy reduces high-sensitivity C-reactive protein levels as well cholesterol, but no prospective trials directly addressed the issue of whether elevated are beneficial for apparently healthy persons with LDL cholesterol below current thresholds treatment. This randomized, double-blind, placebo-controlled, multicenter trial study was part Justification Use Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) Study. The...
Clonal hematopoiesis of indeterminate potential (CHIP), which is defined as the presence an expanded somatic blood-cell clone in persons without other hematologic abnormalities, common among older and associated with increased risk cancer. We previously found preliminary evidence for association between CHIP atherosclerotic cardiovascular disease, but nature this was unclear.
Healing of myocardial infarction (MI) requires monocytes/macrophages. These mononuclear phagocytes likely degrade released macromolecules and aid in scavenging dead cardiomyocytes, while mediating aspects granulation tissue formation remodeling. The mechanisms that orchestrate such divergent functions remain unknown. In view the heightened appreciation heterogeneity circulating monocytes, we investigated whether distinct monocyte subsets contribute specific ways to ischemic injury mouse MI....
Monitoring Monocyte Reservoirs Monocytes are cells of the immune system that recruited to sites tissue injury and inflammation where they help resolve infection important for repair. The bone marrow blood believed be primary reservoirs from which monocytes mobilized after injury. Swirski et al. (p. 612 ; see Perspective by Jia Pamer ) now demonstrate spleen also serves as a critical reservoir during ischemic myocardial in very similar phenotype blood-derived injured heart, represent large...
ContextPrior intravascular ultrasound (IVUS) trials have demonstrated slowing or halting of atherosclerosis progression with statin therapy but not shown convincing evidence regression using percent atheroma volume (PAV), the most rigorous IVUS measure disease and regression.ObjectiveTo assess whether very intensive could regress coronary as determined by imaging.Design SettingProspective, open-label blinded end-points trial (A Study to Evaluate Effect Rosuvastatin on Intravascular...
To test the hypothesis that nitric oxide (NO) limits endothelial activation, we treated cytokine-stimulated human saphenous vein cells with several NO donors and assessed their effects on inducible expression of vascular cell adhesion molecule-1 (VCAM-1). In a concentration-dependent manner, inhibited interleukin (IL)-1 alpha-stimulated VCAM-1 by 35-55% as determined surface enzyme immunoassays flow cytometry. This inhibition was paralleled reduced monocyte to monolayers in nonstatic assays,...
Macrophage accumulation participates decisively in the development and exacerbation of atherosclerosis. Circulating monocytes, precursors macrophages, display heterogeneity mice humans, but their relative contribution to atherogenesis remains unknown. We report here that Ly-6Chi monocyte subset increased dramatically hypercholesterolemic apoE–deficient consuming a high-fat diet, with number cells doubling blood every month. monocytes adhered activated endothelium, infiltrated lesions, became...