A5029124921- Heparin-Induced Thrombocytopenia and Thrombosis
- Platelet Disorders and Treatments
- Intramuscular injections and effects
- Blood groups and transfusion
- Complement system in diseases
- Monoclonal and Polyclonal Antibodies Research
- Glioma Diagnosis and Treatment
- Neurological and metabolic disorders
- Cerebral Venous Sinus Thrombosis
- Hemoglobinopathies and Related Disorders
- Blood disorders and treatments
- Bacillus and Francisella bacterial research
- Venous Thromboembolism Diagnosis and Management
- Innovative Microfluidic and Catalytic Techniques Innovation
University Hospital of North Norway
2021-2023
Aalborg University Hospital
2021
Aarhus University Hospital
2021
The COVID-19 vaccine from AstraZeneca (AZD1222) is one of several vaccines introduced to provide immunity against SARS-CoV-2. Recently, more than 50 cases have been reported presenting a combination thrombosis, thrombocytopenia, and remarkably high levels anti-platelet factor 4 (PF4)/polyanion antibodies post-AZD1222 vaccination. Now linked the vaccine, condition referred as vaccine-induced immune thrombotic thrombocytopenia. European Medicines Agency still recommends vaccination with...
During a 2-week period, we have encountered five cases presenting with the combination of cerebral venous thrombosis (CVT), intracerebral hemorrhage and thrombocytopenia. A clinical hallmark was rapid severe progression disease in spite maximum treatment efforts, resulting fatal outcome for 4 out 5 patients. All had received ChAdOx1 nCov-19 vaccine 1–2 weeks earlier developed characteristic syndrome thereafter. The progressive course high fatality rate CVT thrombocytopenia such cluster...
Maternal alloantibodies to human platelet antigen-1a can cause severe intracranial hemorrhage in a fetus or newborn. Although never evaluated placebo-controlled clinical trials, most Western countries use off-label weekly administration of high-dosage intravenous immunoglobulin all pregnant women with an obstetrical history fetal and neonatal alloimmune thrombocytopenia. In Norway, antenatal is only recommended pregnancies wherein previous child had (high-risk) generally not given other...
SARS-CoV-2 adenoviral vector DNA vaccines have been linked to the rare but serious thrombotic postvaccine complication vaccine-induced immune thrombocytopenia. This has raised concerns regarding possibility of increased risk after any vaccines.To investigate whether cause coagulation activation leading a hypercoagulable state.This observational study included 567 health care personnel; 521 were recruited first dose ChAdOx1-S (Vaxzevria, AstraZeneca) vaccine and 46 prospectively before...
Abstract We describe the first Danish case of presumed inflammatory and thrombotic response to vaccination with an adenoviral (ChAdOx1) vector based COVID-19 vaccine (AZD1222). The describes a 60-year old woman, who was admitted intractable abdominal pain seven days after receiving vaccine. Computer Tomography (CT) abdomen revealed bilateral adrenal hemorrhages. On following day she developed massive right sided ischemic stroke Magnetic Resonance Imaging (MRI) angiography showed occlusion...
The field of transfusion medicine started out with whole blood to treat severe anaemia and other deficiencies, then transitioned component therapy, largely leaving the practice, experiences, transfusions behind. Currently, is circling back gaining ground as an alternative massive protocols.Herein we describe a severely anaemic paroxysmal nocturnal haemoglobinuria (PNH) patient initially suspected suffering from renal haemorrhage, receiving standard low-titre group O during pre-hospital...
Drug-induced immune thrombocytopenia (DITP) is a rare, but serious complication to wide range of medications. Upon suspicion, one should do thorough clinical evaluation following proposed diagnostic criteria and seek laboratory confirmation. If confirmed, it important ensure avoidance the drug in future.Herein, we describe young adult male who experienced two bouts severe dental treatment. The was acknowledged due unexpected hemorrhaging during procedures. On both occasions, he exposed four...
Background: Anti-SARS-CoV-2 adenoviral-vectored-DNA vaccines have been linked to a rare but serious thrombotic post-vaccine complication called the vaccine-induced immune thrombocytopenia (VITT). VITT has raised concerns regarding possibilities of increased risk and after anti-COVID-19 vaccines. Aims: To investigate whether anti-SARS-CoV-2 can cause thrombocytopenia, coagulation activation thrombin generation leading hypercoagulable state. Methods: In this study, 567 healthcare personnel...