Deep non-rapid eye movement sleep (NREM) and general anesthesia with propofol are prominent states of reduced arousal linked to the occurrence synchronized oscillations in electroencephalogram (EEG). Although rapid (REM) is also associated diminished levels, it characterized by a desynchronized, ‘wake-like’ EEG. This observation implies that not necessarily only defined synchronous oscillatory activity. Using intracranial surface EEG recordings four independent data sets, we demonstrate 1/f...

Population-based data on the prevalence of persistent postsurgical pain are scarce. This study aimed to assess in a general population and describe associated physical, social, psychological factors, including symptoms nerve injury sensitization. A cross-sectional survey was performed northern Norway with questionnaire items covering surgery, pain, sensory abnormalities area surgery. Of 12,982 participants, 24.0% (3111) had undergone one or more surgical procedures during 3 years preceding...

The Shamrock technique is a new method for ultrasound-guided lumbar plexus blockade. Data on the optimal local anaesthetic dose are not available.The objective of this study to estimate effective ropivacaine 0.5% block.A prospective dose-finding using Dixon's up-and-down sequential method.University Hospital Orthopaedic Anaesthesia Unit.Shamrock block performance and assessment were scheduled preoperatively. Ropivacaine was titrated with Dixon Massey stepwise change 5 ml in each consecutive...

How and to what extent electrical brain activity reflects pharmacologically altered states contents of consciousness, is not well understood. Therefore, we investigated whether measures evoked spontaneous electroencephalographic (EEG) signal diversity are by sub-anaesthetic levels ketamine compared normal wakefulness, how these relate subjective experience. High-density 62-channel EEG was used record responses transcranial magnetic stimulation (TMS) in 10 healthy volunteers before during...

Background: In previous studies on glucocorticoids for postoperative pain, the test drug has been given perioperatively, usually before measurement of baseline pain. order to evaluate time course and magnitude analgesic effect a glucocorticoid in well‐established we compared methylprednisolone with ketorolac placebo, after assessment pain first day. Methods: This was double‐blind, single dose, randomized, parallel comparison intravenous (i.v.) 125 mg, 30 mg as an active control, placebo 75...

We studied the prevalence of chronic pain and long term sensory changes after cosmetic augmentation mammoplasty effects a single i.v. preoperative dose methylprednisolone 125 mg (n=74), parecoxib 40 (n=71), or placebo (n=74). A questionnaire was mailed 6 weeks 1 year surgery. Response rate 80%. At non-evoked present in 13%, evoked 20% with no statistically significant differences between groups. Methylprednisolone associated reduced odds for hyperesthesia at (OR 0.3, 95% CI 0.1-0.6),...

We compared methylprednisolone 125 mg IV (n = 68) and parecoxib 40 with placebo given before breast augmentation surgery in a randomized, double-blind parallel group study. Surgery was performed under local anesthesia combined propofol/fentanyl sedation. Methylprednisolone decreased pain at rest dynamic intensity from 1 to 6 h after (mean summed intensity(1-6 h): [17.25; 95% confidence interval [CI], 14.85-19.65] versus [21.7; CI, 19.3-24.1]; P < 0.03; [15.25; 13.25-17.25] placebo; 0.001;...

During a 2-week period, we have encountered five cases presenting with the combination of cerebral venous thrombosis (CVT), intracerebral hemorrhage and thrombocytopenia. A clinical hallmark was rapid severe progression disease in spite maximum treatment efforts, resulting fatal outcome for 4 out 5 patients. All had received ChAdOx1 nCov-19 vaccine 1–2 weeks earlier developed characteristic syndrome thereafter. The progressive course high fatality rate CVT thrombocytopenia such cluster...

•Fatigue was highly prevalent one year after ICU admission in survivors with COVID-19.•Younger age, pain/discomfort, dyspnoea, and mental health symptoms were associated reports of fatigue.•COVID-19 should be assessed comprehensive symptom screening during follow-up care.

Abstract Background The bispectral index (BIS) monitor is the most frequently used electroencephalogram (EEG)‐based depth of anesthesia (DoA) technology in Norwegian hospitals. However, there limited knowledge regarding extent and clinical impact its use how anesthesiologists nurse anesthetists information provided by DoA monitors their practice. Methods This cross‐sectional survey on Norway a web‐based questionnaire distributed to personnel all hospitals Norway. Participation was voluntary...

Background The Onvision needle tip tracking (NTT) is a new technology consisting of with an ultrasound sensor close to the and console for computerised signal processing. aim study was evaluate NTT during ultrasound‐guided simulated peripheral nerve block procedures in porcine phantom model. Methods Forty anaesthesiologists performed in‐plane out‐of‐plane blocks without guidance. primary outcome measure procedure time. Secondary outcomes were hand movements path length travelled by hands...

Abstract Background Mortality and morbidity of aneurysmal subarachnoid haemorrhage (aSAH) remain high, prognosis is influenced by multiple non-modifiable factors such as aSAH severity. By analysing the chronology management, we aim at identifying modifiable with emphasis on occurrence rebleeds in a setting 24/7 surgical endovascular availability aneurysm repair routine administration tranexamic acid. Methods Retrospective analysis institutional quality registry data cases admitted into...

Glucocorticoids and non-steroidal anti-inflammatory drugs (NSAIDs) decrease acute postoperative pain hyperalgesia. The objectives of this study were to investigate the effects methylprednisolone ketorolac on hyperalgesia around a skin burn injury pressure thresholds.In double-blind, placebo-controlled, randomized trial with cross-over design, 125 mg, 60 mg or placebo was administered intravenously in 12 male volunteers three separate days at least 4 apart. Primary secondary produced by...

Background Prophylactic dexamethasone, ondansetron and droperidol have a documented effect on post‐operative nausea vomiting ( PONV ). Still, there is lack of studies investigating the adding dexamethasone to in order treat established . Methods In this double‐blind randomised, controlled trial, we compared triple prophylaxis for consisting 8 mg intravenous IV ), 4 0.625 n = 157) with placebo 156) given before gynaecological day‐case surgery. Subsequently, those having despite or placebo,...

Objective: The objective of this study was to test whether properties one second segments spontaneous scalp EEG activity can be used automatically distinguish the awake state from anesthetized in patients undergoing general propofol anesthesia. Methods: 25 channel recorded 10 intravenous anesthesia with remifentanil during anterior cervical discectomy and fusion. From this, we extracted by applying Directed Transfer Function (DTF) directly every one-second segment raw, signal. were develop a...

During a military exercise in northern Norway March 2000, the snow-laden roof of command center collapsed with 76 persons inside. Twenty-five were entrapped and/or buried under snow masses. There three deaths. Seven patients had serious injuries, moderate and 16 minor injuries. A Convalescence Camp that been set up Sports Hall 125 meters from scene was reorganized as causality clearing station. Officers initially organized search rescue. In all, 417 took part rescue work 36 ambulances, 17...

Abstract Combining an NSAID and paracetamol (acetaminophen) has in some studies given superior analgesia compared with the single drugs. In other trials no additive effect been found. We have investigated of this drug combination on pressure pain tolerance threshold (PPTT), a reproducible correlate to clinical pain. The aim double blind, randomised, placebo controlled, crossover study was evaluate i.v. propacetamol 2 g (=paracetamol 1 g) ketorolac 30 mg, individually combination, PPTT 16...

Abstract Deep non-rapid eye movement sleep (NREM) – also called slow wave (SWS) and general anesthesia are prominent states of reduced arousal linked to the occurrence oscillations in electroencephalogram (EEG). Rapid (REM) sleep, however, is associated with a diminished level, but characterized by desynchronized, ‘wake-like’ EEG. This observation challenges notion as main physiological mediator arousal. Using intracranial surface EEG recordings four independent data sets, we establish 1/f...

Summary Technology that facilitates performance of deep peripheral nerve blocks is clinical interest. The Onvision™ a new device for ultrasonographic needle tip tracking incorporates an ultrasound sensor on the then represented by green circle screen. primary aim this study was to investigate effect procedural time in first human volunteer study. Secondary outcome measures included: number hand movements; movement path length; block success rate; onset time; duration; discomfort experienced...

Abstract Resistance breathing may restore cardiac output (CO) and cerebral blood flow (CBF) during hypovolemia. We assessed CBF autoregulation (CA) tilt, resistance breathing, paced in 10 healthy subjects. Blood velocities the internal carotid artery (ICA), middle arteries (MCA, four subjects), aorta were measured by Doppler ultrasound 30° 60° semi‐recumbent positions. ICA CO calculated. Arterial pressure (ABP, Finometer), end‐tidal 2 (ETCO ) recorded. response was mixed‐models regression...

Background Gabapentinoids are increasingly used to reduce acute postoperative pain, opioid consumption and opioid‐related adverse effects. We explored the opioid‐sparing, analgesic anti‐hyperalgesic effect of perioperative administered pregabalin in laparoscopic living donor nephrectomy. Methods In this randomized controlled trial, 80 patients were recruited receive 150 mg twice daily or placebo on day surgery first as part a multimodal regimen. Primary outcome was 0–48 h after surgery....