A5039999079- Neural dynamics and brain function
- Sleep and Wakefulness Research
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
- Visual perception and processing mechanisms
- Sleep and related disorders
- Photoreceptor and optogenetics research
- Circadian rhythm and melatonin
- Transcranial Magnetic Stimulation Studies
- Epilepsy research and treatment
- Neuroscience and Neural Engineering
- Advanced Thermodynamics and Statistical Mechanics
- Neurological disorders and treatments
- Children's Physical and Motor Development
- Spatial Neglect and Hemispheric Dysfunction
- Plant and Biological Electrophysiology Studies
- Mechanical and Optical Resonators
- Advanced Memory and Neural Computing
- Motor Control and Adaptation
- Fractal and DNA sequence analysis
- Origins and Evolution of Life
- Biofield Effects and Biophysics
University of Tübingen
2020-2025
University Hospital and Clinics
2020-2024
Hertie Institute for Clinical Brain Research
2020-2024
University Medical Center
2020-2024
University of California, Berkeley
2015-2019
University of Oslo
2016-2019
Berkeley College
2019
University Medical Center Hamburg-Eppendorf
2013-2016
Universität Hamburg
2013-2016
RWTH Aachen University
2012
Deep non-rapid eye movement sleep (NREM) and general anesthesia with propofol are prominent states of reduced arousal linked to the occurrence synchronized oscillations in electroencephalogram (EEG). Although rapid (REM) is also associated diminished levels, it characterized by a desynchronized, ‘wake-like’ EEG. This observation implies that not necessarily only defined synchronous oscillatory activity. Using intracranial surface EEG recordings four independent data sets, we demonstrate 1/f...
Oscillatory neuronal synchronization between cortical areas has been suggested to constitute a flexible mechanism coordinate information flow in the human cerebral cortex. However, it remains unclear whether synchronized activity merely represents an epiphenomenon or is causally involved selective gating of information. Here, we combined bilateral high-density transcranial alternating current stimulation (HD-tACS) at 40 Hz with simultaneous electroencephalographic (EEG) recordings study...
How are memories transferred from short-term to long-term storage? Systems-level memory consolidation is thought be dependent on the coordinated interplay of cortical slow waves, thalamo-cortical sleep spindles and hippocampal ripple oscillations. However, it currently unclear how selective interaction these cardinal oscillations organized support information reactivation transfer. Here, using human intracranial recordings, we demonstrate that prefrontal cortex plays a key role in organizing...
Recent proposals suggest that sleep may be a factor associated with accumulation of two core pathological features Alzheimer9s disease (AD): tau and β-amyloid (Aβ). Here we combined PET measures Aβ tau, electroencephalogram recordings, retrospective evaluations to investigate the potential utility in predicting <i>in vivo</i> AD pathology male female older adults. Regression analyses revealed severity impaired slow oscillation-sleep spindle coupling predicted greater medial temporal lobe...
Precise temporal coordination of slow oscillations (SO) and sleep spindles is a fundamental mechanism sleep-dependent memory consolidation. SO spindle morphology changes considerably throughout development. Critically, it remains unknown how the precise these two develops during brain maturation whether their synchronization indexes development networks. Here, we use longitudinal study design spanning from childhood to adolescence, where participants underwent polysomnography performed...
Significance Neural oscillations have been shown to support a range of cognitive abilities. Here we demonstrate that delta activity (2–4 Hz) in the prefrontal cortex tracked current task context and modulated sensory processing top-down manner. We show frontal parietooccipital alpha (8–12 are functionally coupled jointly guide visual perception integrate evidence with demands. observed strong moment-to-moment behavioral fluctuations, which cycled at rate endogenous oscillatory brain...
The proposed mechanisms of sleep-dependent memory consolidation involve the overnight regulation neural activity at both synaptic and whole-network levels. Now, there is a lack in vivo data humans elucidating if, how, sleep its varied stages balance activity, if such recalibration benefits memory. We combined electrophysiology with two-photon calcium imaging rodents as well intracranial scalp electroencephalography (EEG) to reveal key role for non-oscillatory brain during rapid eye movement...
Abstract Contextual cues and prior evidence guide human goal-directed behavior. The neurophysiological mechanisms that implement contextual priors to subsequent actions in the brain remain unclear. Using intracranial electroencephalography (iEEG), we demonstrate increasing uncertainty introduces a shift from purely oscillatory mixed processing regime with an additional ramping component. Oscillatory dynamics reflect dissociable signatures, which likely differentially contribute encoding...
Previously, we demonstrated that precise temporal coordination between slow oscillations (SOs) and sleep spindles indexes declarative memory network development (Hahn et al., 2020). However, it is unclear whether these findings in the domain also apply motor domain. Here, compared adolescents adults learning juggling, a real-life gross-motor task. Juggling performance was impacted by time of day effects. Critically, found improved task proficiency after lead to an attenuation curve,...
The human prefrontal cortex (PFC) constitutes the structural basis underlying flexible cognitive control, where mixed-selective neural populations encode multiple task features to guide subsequent behavior. mechanisms by which brain simultaneously encodes task–relevant variables while minimizing interference from task-irrelevant remain unknown. Leveraging intracranial recordings PFC, we first demonstrate that competition between coexisting representations of past and present incurs a...
Epilepsy is considered as a network disorder of interacting brain regions. The propagation local epileptic activity from the seizure onset zone (SOZ) along neuronal networks determines semiology seizures. However, in highly interconnected regions such insula, association between SOZ and blurred necessitating invasive stereoelectroencephalography (SEEG). Normative connectomes on MRI data enable to link different symptoms lesion locations common functional network. present study applied...
Spatial attention improves visual perception by selecting behaviorally relevant sensory signals. Traditionally, has been conceptualized as a static spotlight, while recent evidence posited that operates moving spotlight samples space sequentially in discrete snapshots are clocked theta rhythms (~3-8 Hz). While rhythmic attentional sampling mainly observed fronto-parietal and occipital areas, oscillations also hallmark entorhinal-hippocampal grid-cell networks, which encode physical hexagonal...
Prior expectations bias how we perceive the world. Despite well-characterized behavioral effects of priors, such as confirmation bias, their neural mechanisms remain unclear. Contemporary theories postulate conflicting predictions: does brain enhance expected sensory information (sharpening representation) or rather prioritize unexpected (dampening representations)? Here, combined reversal learning with a noisy motion discrimination task to investigate priors impact and action processing....
Ambiguous stimuli have been widely used to study the neuronal correlates of consciousness. Recently, it has suggested that conscious perception might arise from dynamic interplay functionally specialized but distributed cortical areas. While previous research mainly focused on phase coupling as a correlate communication, more recent findings indicated additional modes coexist and possibly subserve distinct functions. Here, we studied two modes, namely envelope coupling, which differ in their...