A5087287890- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Respiratory Support and Mechanisms
- Surgical Simulation and Training
- Intraoperative Neuromonitoring and Anesthetic Effects
- Anesthesia and Pain Management
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Gut microbiota and health
- Pneumonia and Respiratory Infections
- Clostridium difficile and Clostridium perfringens research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nosocomial Infections in ICU
- Antibiotic Use and Resistance
- Retinal and Optic Conditions
- Hepatitis C virus research
- Vascular Procedures and Complications
- Nerve Injury and Rehabilitation
- Aerodynamics and Fluid Dynamics Research
- COVID-19 and healthcare impacts
- COVID-19 and Mental Health
- Diagnosis and Treatment of Venous Diseases
- Venous Thromboembolism Diagnosis and Management
- Pneumocystis jirovecii pneumonia detection and treatment
Oslo University Hospital
2019-2024
University of Oslo
2019-2024
Smerteklinikken
2023-2024
New treatment modalities are urgently needed for patients with COVID-19. The World Health Organization (WHO) Solidarity trial showed no effect of remdesivir or hydroxychloroquine (HCQ) on mortality, but the antiviral effects these drugs not known.To evaluate and HCQ all-cause, in-hospital mortality; degree respiratory failure inflammation; viral clearance in oropharynx.NOR-Solidarity is an independent, add-on, randomized controlled to WHO that included biobanking 3 months clinical follow-up...
Although coronavirus disease 2019 (COVID-19) is primarily a respiratory infection, mounting evidence suggests that the gastrointestinal tract involved in disease, with gut barrier dysfunction and microbiota alterations being related to severity. Whether these persist are long-term remains unknown.Plasma was collected during hospital admission after 3 months from NOR-Solidarity trial (n = 181) analyzed for markers of inflammation. At 3-month follow-up, pulmonary function assessed by measuring...
To determine the incidence and characteristics of superinfections in mechanically ventilated COVID-19 patients, impact dexamethasone as standard therapy.This multicentre, observational, retrospective study included patients ≥ 18 years admitted from March 1st 2020 to January 31st 2021 with infection who received mechanical ventilation. Patient characteristics, clinical therapy survival were examined.155/156 (115 men, mean age 62 years, range 26-84 years) included. 67 (43%) had 90...
Abstract The association between pulmonary sequelae and markers of disease severity, as well pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for COVID-19. COPD assessment test (CAT-score), spirometry, diffusion capacity the lungs (DL CO ), chest-CT performed at 23 Norwegian hospitals included NOR-SOLIDARITY trial, an open-labelled, randomised clinical investigating efficacy remdesivir hydroxychloroquine (HCQ). Thirty-eight percent had a CAT-score ≥ 10....
Abstract Background Immune dysregulation is a major factor in the development of severe coronavirus disease 2019 (COVID-19). The homeostatic chemokines CCL19 and CCL21 have been implicated as mediators tissue inflammation, but data on their regulation acute respiratory syndrome 2 (SARS-CoV-2) infection limited. We thus investigated levels these COVID-19 patients. Methods Serial blood samples were obtained from patients hospitalized with (n = 414). Circulating during hospitalization 3-month...
Background The Onvision needle tip tracking (NTT) is a new technology consisting of with an ultrasound sensor close to the and console for computerised signal processing. aim study was evaluate NTT during ultrasound‐guided simulated peripheral nerve block procedures in porcine phantom model. Methods Forty anaesthesiologists performed in‐plane out‐of‐plane blocks without guidance. primary outcome measure procedure time. Secondary outcomes were hand movements path length travelled by hands...
Summary Technology that facilitates performance of deep peripheral nerve blocks is clinical interest. The Onvision™ a new device for ultrasonographic needle tip tracking incorporates an ultrasound sensor on the then represented by green circle screen. primary aim this study was to investigate effect procedural time in first human volunteer study. Secondary outcome measures included: number hand movements; movement path length; block success rate; onset time; duration; discomfort experienced...
Abstract Objectives To investigate temporal changes in the association between SARS‐CoV2 viral load (VL) and markers of inflammation during hospitalization, as well ability these alone or combination to predict severe outcomes. Methods Serial oropharyngeal blood samples were obtained from hospitalized COVID‐19 patients ( n = 160). Levels inflammatory VL measured hospitalization (admission, days 3–5, 7–10) related outcomes (respiratory failure/intensive care unit admission). Results Elevated...
Background Onvision is a new technology for needle tip detection and tracking in ultrasound-guided regional anesthesia. The system consists of piezoelectric sensor close to the an electronic console integrated ultrasound system. visualized by green circle on screen. aim study was investigate effect in-plane infraclavicular plexus blocks. Methods randomized, controlled, observer blinded cross-over trial 26 healthy volunteers. Two specialists anesthesiology performed lateral sagittal brachial...
Background: There is an urgent need for new treatment modalities in COVID-19 patients. Recently, the WHO Solidarity trial showed no effects of remdesivir or hydroxychloroquine (HCQ) on mortality. However, antiviral these drugs and possible relation to clinical characteristics at admission not known.Methods: NOR-Solidarity independent add-on study trial, including biobanking, a three-month follow-up. Eligible patients were adults (≥18 years) admitted hospital with laboratory-confirmed...
Abstract Objective Although COVID-19 is primarily a respiratory infection, mounting evidence suggests that the GI tract involved in disease, with gut barrier dysfunction and microbiota alterations being related to disease severity. Whether these persist could be long-term unknown. Design From NOR-Solidarity trial (n=181), plasma was collected during hospital admission after three months, analyzed for markers of inflammation. At three-month follow-up, pulmonary function assessed by measuring...
16.01.2024: Kort rapport - Ti av tretten gravide pasienter innlagt ved Rikshospitalets intensivenheter med akutt respirasjonssvikt utløst covid-19 ble intubert etter terapisvikt non-invasiv mekanisk ventilasjon.
There is an unmet need for treatment of long-term symptoms following COVID-19. Remdesivir currently the only antiviral approved by European Medicines Agency hospitalised patients. Here, we report on effect remdesivir in addition to standard care and quality life patients with COVID-19 as part open-label randomised NOR-Solidarity trial (NCT04321616). A total 185 were included main trial, which 118 (60%) either (n = 42; 36%) or a post-hoc defined control group composed who received alone...
30.01.2023: Kort rapport - Av 30 pasienter behandlet med venovenøs ekstrakorporal membranoksygenering (ECMO) for covid-19-utløst akutt lungesviktsyndrom (ARDS) ble 14 (47 %) utskrevet fra sykehus i live.
Essentials•Blood clotting laboratory tests were performed in hospital and 3 months later severe COVID-19.•Tissue factor pathway inhibitor correlated with severity 3-month lung pathology.•Tissue plasminogen activator disease severity.•Tissue tissue may be involved the pathogenesis of COVID-19 disease.AbstractBackgroundSeveral studies have examined parameters increased thrombogenicity COVID-19, but examining their association long-term outcome potential effects antiviral agents hospitalized...
<h3>Background and aims</h3> The Onvision™ is a new technology for needle tip tracking (NTT). makes use of piezoelectric sensor on the that represented by green circle ultrasound screen (figure 1). In phantom study NTT significantly reduced procedure time out-of-plane simulated blocks (Kåsine et al. 2019). aim this was to investigate effect hand motion analysis in first-in-human volunteer study. <h3>Methods</h3> This randomised, controlled, crossover healthy volunteers. Two...
Aim: Quadratum lumborum block II (QL II) is a method used for pain control after abdominal surgeons.In this study, we aimed to retrospectively investigate the effect of ultrasound-guided QL on postoperative analgesia and opioid consumption in Inguinal Hernia repair surgery (IHC) operations under general
Abstract BacgroundSuper-infections in COVID-19 patients with acute respiratory distress syndrome (ARDS) on mechanical ventilation were initially reported to be rare. Little is known of their incidence after dexamethasone was introduced as standard care. We aimed determine the and characteristics superinfections mechanically ventilated during course pandemic, explore possible impact introduction therapy. MethodsIn this national, multi-center, observational, retrospective study we included ≥...