A5020571500- Cardiac Arrest and Resuscitation
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Musculoskeletal pain and rehabilitation
- SARS-CoV-2 and COVID-19 Research
- Heart Rate Variability and Autonomic Control
- Clostridium difficile and Clostridium perfringens research
- Anesthesia and Sedative Agents
- Acute Myocardial Infarction Research
- Thermal Regulation in Medicine
- Pain Mechanisms and Treatments
- Cardiac Imaging and Diagnostics
- Gut microbiota and health
- Atrial Fibrillation Management and Outcomes
- Vitamin C and Antioxidants Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Thermoregulation and physiological responses
- Traumatic Brain Injury Research
- Public Relations and Crisis Communication
- Psychosomatic Disorders and Their Treatments
- Pain Management and Placebo Effect
- Underwater Vehicles and Communication Systems
Sørlandet Hospital Arendal
2017-2024
Sørlandet Sykehus
2021
St Olav's University Hospital
2020
Stiftelsen Norsk Luftambulanse
2020
Oslo University Hospital
2011-2014
Silliman University
2005
Haukeland University Hospital
2002
Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence of low certainty.In an open-label trial with blinded assessment outcomes, we randomly assigned 1900 adults coma who had out-of-hospital arrest presumed or unknown cause to undergo targeted hypothermia at 33°C, followed by controlled rewarming, normothermia early treatment fever (body temperature, ≥37.8°C). The primary outcome was death from any 6 months. Secondary outcomes included...
New treatment modalities are urgently needed for patients with COVID-19. The World Health Organization (WHO) Solidarity trial showed no effect of remdesivir or hydroxychloroquine (HCQ) on mortality, but the antiviral effects these drugs not known.To evaluate and HCQ all-cause, in-hospital mortality; degree respiratory failure inflammation; viral clearance in oropharynx.NOR-Solidarity is an independent, add-on, randomized controlled to WHO that included biobanking 3 months clinical follow-up...
Although coronavirus disease 2019 (COVID-19) is primarily a respiratory infection, mounting evidence suggests that the gastrointestinal tract involved in disease, with gut barrier dysfunction and microbiota alterations being related to severity. Whether these persist are long-term remains unknown.Plasma was collected during hospital admission after 3 months from NOR-Solidarity trial (n = 181) analyzed for markers of inflammation. At 3-month follow-up, pulmonary function assessed by measuring...
Summary Chronic pain is associated with both increased hypertension prevalence and impaired blood pressure–related hypoalgesia in a general population sample. Resting pressure (BP) inversely related to sensitivity individuals free of chronic pain, reflecting homeostatic interactions between cardiovascular modulatory systems. Several laboratory studies indicate that BP-related diminished patients, suggesting dysfunction these interacting Separate epidemiological findings reveal elevated the...
Abstract Heart rate variability (HRV) and baroreflex sensitivity (BRS) are indexes reflecting the ability to maintain cardiovascular homeostasis amidst changing conditions. Evidence primarily from small studies suggests that both HRV BRS may be reduced in individuals with chronic pain (CP), potential implications for risk. We compared between CP (broadly defined) pain-free controls a large unselected population sample. Participants were 1143 reporting clinically meaningful 5640 who completed...
Abstract The association between pulmonary sequelae and markers of disease severity, as well pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for COVID-19. COPD assessment test (CAT-score), spirometry, diffusion capacity the lungs (DL CO ), chest-CT performed at 23 Norwegian hospitals included NOR-SOLIDARITY trial, an open-labelled, randomised clinical investigating efficacy remdesivir hydroxychloroquine (HCQ). Thirty-eight percent had a CAT-score ≥ 10....
The Targeted Hypothermia vs Normothermia After Out-of-Hospital Cardiac Arrest (TTM2) trial reported no difference in mortality or poor functional outcome at 6 months after out-of-hospital cardiac arrest (OHCA). This predefined exploratory analysis provides more detailed estimation of brain dysfunction for the comparison 2 intervention regimens.To investigate effects targeted hypothermia normothermia on with focus societal participation and cognitive function survivors OHCA.This study is a an...
Abstract Background Immune dysregulation is a major factor in the development of severe coronavirus disease 2019 (COVID-19). The homeostatic chemokines CCL19 and CCL21 have been implicated as mediators tissue inflammation, but data on their regulation acute respiratory syndrome 2 (SARS-CoV-2) infection limited. We thus investigated levels these COVID-19 patients. Methods Serial blood samples were obtained from patients hospitalized with (n = 414). Circulating during hospitalization 3-month...
Prehospital identification and selection of treatment strategy in patients with suspected non-ST-elevation myocardial infarction (NSTEMI) is challenging. The aim this study was to evaluate the feasibility diagnostic accuracy prehospital ECG, troponin T (TnT) transthoracic echocardiography (TTE) acquired by paramedics early NSTEMI.Consecutive requesting an ambulance from Sorlandet Hospital, Norway due chest pain between November 2017 January 2020 were screened for inclusion study. One...
Abstract Background Targeted temperature management (TTM) is recommended following cardiac arrest; however, time to target varies in clinical practice. We hypothesised the effects of a 33 °C when compared normothermia would differ based on average hypothermia and those patients achieving fastest have more favorable outcomes. Methods In this post-hoc analysis TTM-2 trial, after out hospital arrest were randomized targeted (33 °C), followed by controlled re-warming, or with early treatment...
Due to large beat-to-beat blood pressure variation the use of 24-h ambulatory monitoring in patients with atrial fibrillation has been questioned.Repeatability and variability (Accutraccer II or Diasys Integra), daily was examined 42 aged 51-81 (median 73.5) years admitted for elective electrocardioversion fibrillation.Before cardioversion systolic slightly lower nocturnal reduction larger group who achieved sinus rhythm than maintained (11.5/10.5 versus 4.1/4.7 mmHg; P < 0.05). No...
Both diabetes mellitus (DM) and the metabolic syndrome (MetS) are associated with autonomic neuropathy, which predisposes to cardiac events death. Measures of heart rate variability (HRV) can be used monitor activity nervous system (ANS), there strong indications that HRV study progression ANS-related complications. This aims investigate differences in healthy, MetS diabetic populations. Based on 7880 participants from sixth health survey Tromsø (Tromsø 6, 2007-2008), we found a significant...
Abstract Background The aetiology of delirium is not known, but pre-existing cognitive impairment a predisposing factor. Here we explore the associations between and cerebrospinal fluid (CSF) levels matrix metalloproteinases (MMPs) their tissue inhibitors (TIMPs), proteins with important roles in both acute injury chronic neurodegeneration. Methods Using 13-plex Discovery Assay®, quantified CSF 9 MMPs 4 TIMPs 280 hip fracture patients (140 delirium), 107 cognitively unimpaired individuals,...
Background: There is an urgent need for new treatment modalities in COVID-19 patients. Recently, the WHO Solidarity trial showed no effects of remdesivir or hydroxychloroquine (HCQ) on mortality. However, antiviral these drugs and possible relation to clinical characteristics at admission not known.Methods: NOR-Solidarity independent add-on study trial, including biobanking, a three-month follow-up. Eligible patients were adults (≥18 years) admitted hospital with laboratory-confirmed...
Abstract Objective Although COVID-19 is primarily a respiratory infection, mounting evidence suggests that the GI tract involved in disease, with gut barrier dysfunction and microbiota alterations being related to disease severity. Whether these persist could be long-term unknown. Design From NOR-Solidarity trial (n=181), plasma was collected during hospital admission after three months, analyzed for markers of inflammation. At three-month follow-up, pulmonary function assessed by measuring...
Abstract Background Prehospital risk stratification and timing of revascularization in Acute Coronary Syndromes (ACS) is currently based on the electrocardiogram (ECG). ST- elevation ECG indicates myocardial infarction (STEMI) need immediate reperfusion therapy. However, a large group ACS patients presents without ST-elevation ECG, despite coronary occlusions. In these high non-ST-elevation infarctions (NSTEMI), may be just as crucial for prognosis, but prehospital diagnostic tools to...