Asgeir Johannessen
A5051644982- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Hepatitis Viruses Studies and Epidemiology
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Alcohol Consumption and Health Effects
- SARS-CoV-2 and COVID-19 Research
- Vaccine Coverage and Hesitancy
- Viral Infections and Outbreaks Research
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Blood groups and transfusion
- Acute Myocardial Infarction Research
- Nutritional Studies and Diet
- Cardiovascular Function and Risk Factors
- HIV-related health complications and treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cytomegalovirus and herpesvirus research
- Cardiovascular Disease and Adiposity
- Chronic Obstructive Pulmonary Disease (COPD) Research
- HIV, Drug Use, Sexual Risk
Sykehuset i Vestfold
2017-2025
University of Oslo
2017-2025
Oslo University Hospital
2015-2024
Lovisenberg Diakonale Sykehus
2024
St. Paul's Hospital Millennium Medical College
2024
Hashemite University
2017-2019
University of Jordan
2019
Vestre Viken Hospital Trust
2014-2016
Drammen Hospital
2014
New treatment modalities are urgently needed for patients with COVID-19. The World Health Organization (WHO) Solidarity trial showed no effect of remdesivir or hydroxychloroquine (HCQ) on mortality, but the antiviral effects these drugs not known.To evaluate and HCQ all-cause, in-hospital mortality; degree respiratory failure inflammation; viral clearance in oropharynx.NOR-Solidarity is an independent, add-on, randomized controlled to WHO that included biobanking 3 months clinical follow-up...
Studies of antiretroviral therapy (ART) programs in Africa have shown high initial mortality. Factors contributing to this mortality are poorly described. The aim the present study was assess and identify predictors HIV-infected patients starting ART a rural hospital Tanzania.This cohort 320 treatment-naïve adults who started between October 2003 November 2006. Reliable CD4 cell counts were not available, thus initiation based on clinical criteria accordance with WHO Tanzanian guidelines....
Although coronavirus disease 2019 (COVID-19) is primarily a respiratory infection, mounting evidence suggests that the gastrointestinal tract involved in disease, with gut barrier dysfunction and microbiota alterations being related to severity. Whether these persist are long-term remains unknown.Plasma was collected during hospital admission after 3 months from NOR-Solidarity trial (n = 181) analyzed for markers of inflammation. At 3-month follow-up, pulmonary function assessed by measuring...
Abstract Background Baricitinib has shown efficacy in hospitalized patients with COVID-19, but no placebo-controlled trials have focused specifically on severe/critical COVID, including vaccinated participants. Methods Bari-SolidAct is a phase-3, multicentre, randomised, double-blind, trial, enrolling participants from June 3, 2021 to March 7, 2022, stopped prematurely for external evidence. Patients COVID-19 were randomised 4 mg once daily or placebo, added standard of care. The primary...
Monitoring of antiretroviral treatment (ART) with human immunodeficiency virus (HIV) viral loads, as recommended in industrialized countries, is rarely available resource-limited settings because the high costs and stringent requirements for storage transport plasma. Dried blood spots (DBS) can be an alternative to plasma, but use DBS has not been assessed under field conditions rural Africa. The present study investigates performance HIV load monitoring patients who received ART...
HIV-associated anemia is common and associated with poor prognosis. However, its response to antiretroviral treatment (ART) in rural Africa poorly understood. HIV-infected adults (≥15 years) who enrolled HIV care at Haydom Lutheran Hospital northern Tanzania were included the study. The effect of ART (zidovudine/stavudine + lamivudine efavirenz/nevirapine) on was studied a subset patients anemic time they started had follow-up hemoglobin measurement 12 months later. Pregnant women excluded...
Abstract The association between pulmonary sequelae and markers of disease severity, as well pro-fibrotic mediators, were studied in 108 patients 3 months after hospital admission for COVID-19. COPD assessment test (CAT-score), spirometry, diffusion capacity the lungs (DL CO ), chest-CT performed at 23 Norwegian hospitals included NOR-SOLIDARITY trial, an open-labelled, randomised clinical investigating efficacy remdesivir hydroxychloroquine (HCQ). Thirty-eight percent had a CAT-score ≥ 10....
Stopping nucleos(t)ide analogue (NA) therapy in patients with chronic hepatitis B (CHB) may trigger a beneficial immune response leading to HBsAg loss, but clinical trials on re-start strategies are lacking.
BACKGROUND Chronic hepatitis B (CHB) virus infection is a major cause of liver-associated morbidity and mortality, particularly in low-income countries. A better understanding the epidemiological, clinical, virological characteristics CHB will guide appropriate treatment strategies improve control management Ethiopia. AIM To investigate Eastern Ethiopia assess efficacy safety antiviral treatment. METHODS This cohort study included 193 adults who were human immunodeficiency virus-negative...
In the absence of liver biopsy, World Health Organization recommends non-invasive tests, such as aspartate aminotransferase to platelet ratio index and FIB-4, assess fibrosis in patients with chronic hepatitis B. However, these tests are not well validated sub-Saharan Africa. Recently, a new marker, gamma-glutamyl transpeptidase ratio, was found be more accurate an African setting, but this needs confirmation other cohorts.A treatment program for B initiated Addis Ababa, Ethiopia, 2015....
Background . The Middle East is the home to most obese population in world, and type 2 diabetes mellitus endemic region. However, little known about risk factors for younger age groups. Methods Finnish Diabetes Risk Score (FINDRISC) a simple, validated tool identify persons at of diabetes. We investigated students Hashemite University Jordan with FINDRISC measured fasting plasma glucose those who were categorized high-risk group. Results Overall, 1821 (881 [48.4%] female) included study....
Abstract Timely initiation of HBV treatment is essential for improving prognosis and outcomes. In Ethiopia, the use Xpert hepatitis B virus viral load kit significantly shortened turnaround time compared to standard laboratory methods. By reducing a decision one day, allowed quicker at lower costs, potentially saving lives that might otherwise be lost due delays.
Virological response to antiretroviral treatment (ART) in rural Africa is poorly described. We examined virological efficacy and emergence of drug resistance adults receiving first-line ART for up 4 years Tanzania.Haydom Lutheran Hospital has provided HIV-infected patients since October 2003. A combination stavudine or zidovudine with lamivudine either nevirapine efavirenz the standard regimen. Nested a longitudinal cohort study consecutively starting ART, we carried out cross-sectional...
Hepatitis B virus (HBV) infection is assumed to be the major cause of chronic liver disease (CLD) in sub-Saharan Africa. The contribution other aetiological causes CLD less well documented and hence opportunities modulate potential risk factors are being lost. aims this study were explore spectrum eastern Ethiopia identify plausible underlying for its development.A cross-sectional was undertaken between April 2015 2016 two public hospitals Harar, Ethiopia. population comprised consenting...
Abstract Background Immune dysregulation is a major factor in the development of severe coronavirus disease 2019 (COVID-19). The homeostatic chemokines CCL19 and CCL21 have been implicated as mediators tissue inflammation, but data on their regulation acute respiratory syndrome 2 (SARS-CoV-2) infection limited. We thus investigated levels these COVID-19 patients. Methods Serial blood samples were obtained from patients hospitalized with (n = 414). Circulating during hospitalization 3-month...