A5011164078- Heat shock proteins research
- Endoplasmic Reticulum Stress and Disease
- Cell death mechanisms and regulation
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Extracellular vesicles in disease
- CAR-T cell therapy research
- Cancer-related Molecular Pathways
- Acute Lymphoblastic Leukemia research
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- DNA Repair Mechanisms
- HIV/AIDS Research and Interventions
- Toxin Mechanisms and Immunotoxins
- Cancer therapeutics and mechanisms
- thermodynamics and calorimetric analyses
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Erythrocyte Function and Pathophysiology
- Immune Cell Function and Interaction
- ATP Synthase and ATPases Research
- Connexins and lens biology
- Hemoglobinopathies and Related Disorders
Inserm
2016-2025
Université de Bourgogne
2016-2025
Centre Georges François Leclerc
2016-2025
La Ligue Contre le Cancer
2015-2025
CHU Dijon Bourgogne
1994-2025
Universidad Nacional Autónoma de México
2025
Centre de recherche Translationnelle en Médecine moléculaire
2014-2024
Laboratoire de Recherche Vasculaire Translationnelle
2024
Hospital Universitario Son Espases
2015-2024
Université Bourgogne Franche-Comté
2016-2023
Systemic anticancer chemotherapy is immunosuppressive and mostly induces nonimmunogenic tumor cell death. Here, we show that even in the absence of any adjuvant, cells dying response to anthracyclins can elicit an effective antitumor immune suppresses growth inoculated tumors or leads regression established neoplasia. Although both antracyclins mitomycin C induced apoptosis with caspase activation, only anthracyclin-induced immunogenic death was immunogenic. Caspase inhibition by Z-VAD-fmk...
Myeloid-derived suppressor cells (MDSCs) have been identified in humans and mice as a population of immature myeloid with the ability to suppress T cell activation. They accumulate tumor-bearing shown contribute cancer development. Here, we isolated tumor-derived exosomes (TDEs) from mouse lines that an interaction between TDE-associated Hsp72 MDSCs determines suppressive activity via activation Stat3. In addition, soluble factors triggered MDSC expansion Erk. Stat3 TLR2/MyD88-dependent...
We investigated the mechanisms of immune tolerance raised by tumors comparing immunogenic and tolerogenic tumor cell clones isolated from a rat colon carcinoma. When injected into syngeneichosts, REGb cells yield that are rejected, while PROb progressive inhibit regression tumors. show here volume is correlated with an expansion CD4(+)CD25(+) regulatory T lymphocytes in lymphoid tissues. These delay vivo rejection vitro cell-mediated responses against through mechanism requires contact...
We have previously shown that the small heat shock protein HSP27 inhibited apoptotic pathways triggered by a variety of stimuli in mammalian cells. The present study demonstrates overexpression decreases U937 human leukemic cell sensitivity to etoposide-induced cytotoxicity preventing apoptosis. As observed for Bcl-2, delays poly(ADP-ribose)polymerase cleavage and procaspase-3 activation. In contrast with does not prevent cytochrome c release from mitochondria. cell-free system, addition...
A cellular defense mechanism counteracts the deleterious effects of misfolded protein accumulation by eliciting a stress response. The cytoplasmic deacetylase HDAC6 (histone 6) was previously shown to be key element in this response coordinating clearance aggregates through aggresome formation and their autophagic degradation. Here, for first time, we demonstrate that is involved another crucial cell ubiquitinated aggregates, unravel its molecular basis. Indeed, our data show senses...
In the era of immunotherapies there is an urgent need to implement use circulating biomarkers in clinical practice facilitate personalized therapy and predict treatment response. We conducted a prospective study evaluate usefulness exosomal-PD-L1 melanoma patients' follow-up. studied dynamics from 100 patients by using enzyme-linked immunosorbent assay. found that PD-L1 was secreted through exosomes cells. Exosomes carrying had immunosuppressive properties since they were as efficient cancer...
Exosomes, via heat shock protein 70 (HSP70) expressed in their membrane, are able to interact with the toll-like receptor 2 (TLR2) on myeloid-derived suppressive cells (MDSCs), thereby activating them. We analyzed exosomes from mouse (C57Bl/6) and breast, lung, ovarian cancer patient samples cultured different approaches, including nanoparticle tracking analysis, biolayer interferometry, FACS, electron microscopy. Data were Student's t Mann-Whitney tests. All statistical tests two-sided....
The cysteine proteases known as caspases play a central role in most apoptotic pathways. Here, we show that caspase inhibitors arrest the maturation of human erythroid progenitors at early stages differentiation, before nucleus and chromatin condensation. Effector such caspase-3 are transiently activated through mitochondrial pathway during erythroblast differentiation cleave proteins involved integrity (lamin B) condensation (acinus) without inducing cell death cleavage GATA-1. These...