A5089947551- Mosquito-borne diseases and control
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Viral Infections and Vectors
- Malaria Research and Control
- Axon Guidance and Neuronal Signaling
- Viral Infections and Outbreaks Research
- Dengue and Mosquito Control Research
- Hepatitis C virus research
- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
- Cancer Research and Treatments
- Hippo pathway signaling and YAP/TAZ
- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
- Immune Response and Inflammation
- Mitochondrial Function and Pathology
- Natural Compounds in Disease Treatment
- Hedgehog Signaling Pathway Studies
- Microtubule and mitosis dynamics
- Cutaneous lymphoproliferative disorders research
- Molecular Biology Techniques and Applications
- Bacillus and Francisella bacterial research
- Autophagy in Disease and Therapy
- SARS-CoV-2 detection and testing
École Pratique des Hautes Études
2018-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2024
Université Claude Bernard Lyon 1
2008-2024
Université Paris Sciences et Lettres
2024
Ekaterinburg Research Institute of Viral Infections
2022
Infections Virales et Pathologie Comparée
2016-2022
Virologie et Pathologies Humaines
2016-2022
Laboratoire de Biologie et Modélisation de la Cellule
2013-2016
Centre National de la Recherche Scientifique
2000-2013
École Normale Supérieure de Lyon
2013
Chronic inflammation and cancer are intimately associated. This is particularly true for inflammatory bowel diseases (IBD), such as ulcerative colitis Crohn's disease, which show a major increased risk colorectal cancer. While the understanding of molecular pathogenesis IBD has recently improved, mechanisms that link these chronic states to development in large part unknown. One NF-κB pathway activation turn may contribute tumor formation by providing anti-apoptotic survival signals...
Abstract Hexosylceramides (HexCer) are implicated in the infection process of various pathogens. However, molecular and cellular functions HexCer infectious cycles poorly understood. Investigating enveloped virus Uukuniemi (UUKV), a bunyavirus Phenuiviridae family, we performed lipidomic analysis with mass spectrometry determined lipidome both infected cells derived virions. We found that UUKV alters processing to glycosphingolipids (GSL) cells. The resulted overexpression glucosylceramide...
Abstract Apoptosis is accompanied by major changes in ion compartmentalization and transmembrane potentials. Thymocyte apoptosis characterized an early dissipation of the mitochondrial potential, with transient swelling a subsequent loss plasma membrane potential (ΔΨp) related to cytosolic K+, cellular shrinkage, DNA fragmentation. Thus, gross perturbation ΔΨp occurs at postmitochondrial stage apoptosis. Unexpectedly, we found that blockade K+ channels tetrapentylammonium (TPA), which leads...
Abstractp73 is a recently described member of the p53 family, and, like p53, it undergoes number posttranslational modifications. Here we show, by yeast two-hybrid screening, pull-down assays, and coimmunoprecipitation, that p73α, -β, -γ bind to protein inhibitor activated STAT-1 (PIAS-1) this binding stabilizes p73. PIAS-1 also sumoylates although not C-terminally truncated isoforms p73β -γ, requires RING finger domain PIAS-1. The ΔNp73α isoform can bind, be sumoylated by, PIAS-1-mediated...
Dendritic cells initiate adaptive immune responses, leading either to control cancer by effector T or exacerbate regulatory that inhibit IFN-γ-mediated Th1-type response. can also induce Th17-type immunity, mediated IL-17A. However, the controversial role of this cytokine in requires further investigations. We generated dendritic from peripheral blood monocytes investigate lifespan, phenotype and chemoresistance cells, treated with IL-17A without IFN-γ. Studying expression Bcl-2 family...
Amino-acid coevolution can be referred to mutational compensatory patterns preserving the function of a protein. Viral envelope glycoproteins, which mediate entry enveloped viruses into their host cells, are shaped by signals that confer plasticity evade neutralizing antibodies without altering viral mechanisms. The functions and structures two glycoproteins Hepatitis C Virus (HCV), E1 E2, poorly described. Especially, how these proteins HCV fusion process between cell membrane remains...
The pathogenesis of thymic epithelial tumors remains poorly elucidated. PIK3/Akt/mTOR pathway plays a key role in various cancers; interestingly, several phase I/II studies have reported positive effect mTOR inhibitors disease control thymoma patients. A major limit for deciphering cellular and molecular events leading to the transformation cells or testing drug candidates is lack reliable vitro cell system. We analyzed protein expression activation players Akt/ namely Akt, mTOR, P70S6K...
Netrin-1, a secreted protein recently characterized as relevant cancer therapeutic target, is the antiapoptotic ligand of dependence receptors deleted in colorectal carcinoma and members UNC5H family. Netrin-1 overexpressed several aggressive cancers where it promotes progression by inhibiting cell death induced its receptors. Interference binding to has been shown, through development monoclonal neutralizing antinetrin-1 antibody (currently phase II clinical trial), actively induce...
Abstract The incidence of arbovirus infections has increased dramatically in recent decades, affecting hundreds millions people each year. Togaviridae family includes the chikungunya virus (CHIKV), which is typically transmitted by Aedes mosquitoes and causes a wide range symptoms from flu‐like fever to severe arthralgia. Although conventional diagnostic tests can provide early diagnosis CHIKV infections, access these often limited developing countries. Consequently, there an urgent need...
Hepatitis C virus (HCV) productively infects hepatocytes. Virion surface glycoproteins E1 and E2 play a major role in this restricted cell tropism by mediating entry into particular types. However, several pieces of evidence have suggested the ability patient-derived HCV particles to infect peripheral blood mononuclear cells. The viral determinants mechanisms such events remain poorly understood. Here, we aimed at isolating B lymphocytes. For purpose, constructed library full E1E2 sequences...
Arbovirus emergence and epidemic potential, as approximated by the vectorial capacity formula, depends on host vector parameters, including vector’s intrinsic ability to replicate then transmit pathogen known competence. Vector competence is a complex, time-dependent, quantitative phenotype influenced biotic abiotic factors. A combination of experimental modelling approaches required assess arbovirus intra-vector dynamics estimate potential. In this study, we measured infection,...