A5007179048- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Protein Degradation and Inhibitors
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Genetic factors in colorectal cancer
- Immune Cell Function and Interaction
- Cell death mechanisms and regulation
- Multiple Myeloma Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Childhood Cancer Survivors' Quality of Life
- Heat shock proteins research
- RNA modifications and cancer
- Erythrocyte Function and Pathophysiology
- MicroRNA in disease regulation
- Eosinophilic Disorders and Syndromes
- Dendrimers and Hyperbranched Polymers
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Immunodeficiency and Autoimmune Disorders
- Hematopoietic Stem Cell Transplantation
University of Chicago
2016-2025
University of Chicago Medicine Comprehensive Cancer Center
2018-2025
University of Chicago Medical Center
2007-2022
May Institute
2003-2006
Inserm
2000-2004
John Radcliffe Hospital
2003
Sidney Kimmel Comprehensive Cancer Center
2003
Johns Hopkins University
2003
Children's Mercy Hospital
2003
All India Institute of Medical Sciences
1998-2001
The ten-eleven translocation 1 (TET1) gene is the founding member of TET family enzymes (TET1/2/3) that convert 5-methylcytosine to 5-hydroxymethylcytosine. Although TET1 was first identified as a fusion partner mixed lineage leukemia (MLL) in acute myeloid carrying t(10,11), its definitive role unclear. In contrast frequent down-regulation (or loss-of-function mutations) and critical tumor-suppressor roles three genes observed various types cancers, here we show direct target MLL-fusion...
HSP27 is an ATP-independent chaperone that confers protection against apoptosis through various mechanisms, including a direct interaction with cytochrome c. Here we show overexpression in cell types enhances the degradation of ubiquitinated proteins by 26S proteasome response to stressful stimuli, such as etoposide or tumor necrosis factor alpha (TNF-alpha). We demonstrate binds polyubiquitin chains and vitro vivo. The ubiquitin-proteasome pathway involved activation transcription NF-kappaB...
Individuals with Down syndrome (DS; also known as trisomy 21) have a markedly increased risk of leukemia in childhood but decreased solid tumors adulthood. Acquired mutations the transcription factor–encoding GATA1 gene are observed nearly all individuals DS who born transient myeloproliferative disorder (TMD), clonal preleukemia, and/or develop acute megakaryoblastic (AMKL). do not bear germline analogous to those detected TMD and DS-AMKL predisposed leukemia. To better understand...
Abstract MicroRNAs are subject to precise regulation and have key roles in tumorigenesis. In contrast the oncogenic role of miR-22 reported myelodysplastic syndrome (MDS) breast cancer, here we show that is an essential anti-tumour gatekeeper de novo acute myeloid leukaemia (AML) where it significantly downregulated. Forced expression suppresses leukaemic cell viability growth vitro , substantially inhibits development maintenance vivo . Mechanistically, targets multiple oncogenes, including...
Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic malignancies with variable response to treatment. AMLs bearing MLL (mixed lineage leukemia) rearrangements are associated intermediate or poor survival. MicroRNAs (miRNAs), class small noncoding RNAs, have been postulated be important gene expression regulators virtually in all biological processes, including leukemogenesis. Through large-scale, genome-wide miRNA profiling assay 85 human AML and 15 normal control samples,...
MicroRNAs (miRNAs), small noncoding RNAs that regulate target gene mRNAs, are known to contribute pathogenesis of cancers. Acute myeloid leukemia (AML) is a group heterogeneous hematopoietic malignancies with various chromosomal and/or molecular abnormalities. AML translocations involving the mixed lineage ( MLL ) usually associated poor survival. In present study, through large-scale, genomewide miRNA expression assay, we show microRNA-9 (miR-9) most specifically up-regulated in MLL-...
Survivin, which is the smallest member of inhibitor apoptosis protein (IAP) family, a chromosomal passenger that mediates spindle assembly checkpoint and cytokinesis, also functions as an apoptosis. Frequently overexpressed in human cancers not expressed most adult tissues, survivin has been proposed attractive target for anticancer therapies and, some cases, even touted cancer-specific gene. Survivin is, however, proliferating cells, including hematopoietic stem T-lymphocytes, erythroid...
Myelofibrosis is characterized by bone marrow fibrosis, atypical megakaryocytes, splenomegaly, constitutional symptoms, thrombotic and hemorrhagic complications, a risk of evolution to acute leukemia. The JAK kinase inhibitor ruxolitinib provides therapeutic benefit, but the effects are limited. purpose this study was determine whether targeting AURKA, which has been shown increase maturation potential benefit for patients with myelofibrosis.Twenty-four myelofibrosis were enrolled in phase I...
Primary myelofibrosis (PMF) is a clonal hematologic malignancy characterized by BM fibrosis, extramedullary hematopoiesis, circulating CD34+ cells, splenomegaly, and propensity to evolve acute myeloid leukemia. Moreover, the spleen of patients harbor atypical, clustered megakaryocytes, which contribute disease secreting profibrotic cytokines. Here, we have revealed that megakaryocytes in PMF show impaired maturation associated with reduced GATA1 protein. In investigating cause...