A5100397738- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- RNA Research and Splicing
- RNA Interference and Gene Delivery
- Organ Transplantation Techniques and Outcomes
- Epigenetics and DNA Methylation
- Sepsis Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immune cells in cancer
- Bone Tumor Diagnosis and Treatments
- Hepatitis B Virus Studies
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Cytokine Signaling Pathways and Interactions
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Mesenchymal stem cell research
- Neuroendocrine Tumor Research Advances
- Trauma Management and Diagnosis
- Pelvic floor disorders treatments
- Liver Disease Diagnosis and Treatment
Peking University First Hospital
2017-2025
Peking University
2013-2025
Tongji University
2015-2025
Third Affiliated Hospital of Sun Yat-sen University
2010-2025
Sun Yat-sen University
2014-2025
Central South University
2019-2025
Third Xiangya Hospital
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2025
Second People’s Hospital of Huai’an
2025
Shanghai Skin Disease Hospital
2024-2025
The need for a planned response to deliberate introduction of smallpox has recently become urgent. We constructed stochastic simulator the spread in structured communities compare effectiveness mass vaccination versus targeted close contacts cases. Mass before or immediately after first cases was more effective than preventing and containing epidemics if there no prior herd immunity (that is, immunologic protection within population). postrelease vaccinations increased we assumed that...
Although mesenchymal stem cells (MSCs) have been increasingly trialed to treat a variety of diseases, the underlying mechanisms remain still elusive. In this study, human umbilical cord (UC)-derived MSCs were stimulated by hypoxia, and membrane microvesicles (MVs) in supernatants collected ultracentrifugation, observed under an electron microscope, origin was identified with flow cytometric technique. The results showed that upon hypoxic stimulus, released large quantity MVs ∼100 nm...
Defects of human trophoblast cells may induce miscarriage (abnormal early embryo loss), which is generally regulated by lncRNAs. Ferroptosis a newly identified iron-dependent programmed cell death. Hypoxia an important and unavoidable feature in mammalian cells. However, whether hypoxia might ferroptosis then miscarriage, as well lncRNA, was completely unknown. In this work, we discovered at the first time that could result miscarriage. We also novel lncRNA (lnc-HZ06) simultaneously...
NAD (P) H: quinone oxidoreductase 1 (NQO1) is a xenobiotic metabolizing enzyme that detoxifies chemical stressors and antioxidants, providing cytoprotection in normal tissues. However, high-level expression of NQO1 has been correlated with numerous human malignancies, suggesting role carcinogenesis tumor progression. This study aimed to explore the clinicopathological significance as prognostic determinant breast cancer. A total 176 cancer patients strict follow-up, 45 ductal carcinoma situ...
Colorectal cancer (CRC), which frequently metastasizes to the liver, is one of three leading causes cancer-related deaths worldwide. Growing evidence suggests that a subset cells exists among stem cells. This distinct subpopulation thought contribute liver metastasis; however, it has not been fully explored in CRC yet.Flow cytometry analysis was performed detect subsets with CD133 and CXCR4 markers human primary metastatic tissues. The 'stemness' capacities different subpopulations derived...
Abstract MicroRNAs are subject to precise regulation and have key roles in tumorigenesis. In contrast the oncogenic role of miR-22 reported myelodysplastic syndrome (MDS) breast cancer, here we show that is an essential anti-tumour gatekeeper de novo acute myeloid leukaemia (AML) where it significantly downregulated. Forced expression suppresses leukaemic cell viability growth vitro , substantially inhibits development maintenance vivo . Mechanistically, targets multiple oncogenes, including...
Abstract Epithelial cell adhesion molecule (EpCAM) is known to be highly expressed in a variety of epithelial carcinomas, and it involved proliferation. However, its expression profile biological function nasopharyngeal carcinoma (NPC) remains unclear. In this study, higher EpCAM was found NPC samples compared with non-cancer mucosa by qRT-PCR. Additionally, immunohistochemistry (IHC) analysis specimens from 64 cases showed that high associated metastasis shorter survival. Multivariate...
SM934, an artemisinin derivative, possesses potent antiproliferative and antiinflammatory properties. The aim of this study was to examine the effects explore mechanisms SM934 treat autoimmune disease in lupus-prone female MRL/lpr mice.In vitro, on activation polyclonal CD4+ T cells differentiation naive were examined. In vivo, preventative or therapeutic mice investigated. Ex treatment explored according immunologic correlates disease.In inhibited interferon-γ (IFNγ) interleukin-17 (IL-17)...
As a cause of postoperative complications and early hepatic failure after liver transplantation, ischemia/reperfusion injury (IRI) still has no effective treatment during clinical administration. Although the therapeutic potential mesenchymal stem cells (MSCs) for IRI been previously shown, underlying mechanisms are not completely clear. It is accepted that MSC-derived extracellular vesicles (MSC-EVs) newly uncovered messengers intercellular communication. Herein, it reported umbilical...
Accumulating evidence suggests that atherosclerotic progression depends on persistent and chronic inflammation in the arterial walls. MicroRNA-155 is reportedly involved cardiovascular disease has been implicated as a pro-inflammation regulator. Although some researchers have focused microRNA-155 an atherosclerosis regulator, mechanisms by which functions putative pro-atherosclerosis microRNA are largely unknown. This study aims to analyze microRNA-155's effects explore its...
Triptolide possesses the trait of renal protection.Epithelial-mesenchymal transition (EMT) is closely linked to pathogenesis diabetic kidney disease (DKD).MicroRNAs have recently emerged as critical regulators DKD.However, it poorly understood whether triptolide alleviates EMT by regulating microRNAs in DKD.In this study, we found that decreased albuminuria, improved structure and reduced rats with DKD.Furthermore, activation PI3K/AKT signaling pathway was increased rats, which partly...
Cancer-associated fibroblasts (CAFs) function as a crucial factor in tumor progression by carrying exosomes to neighboring cells. This study was assigned expound the underlying mechanism of CAFs-derived exosomal miR-210 non-small cell lung cancer (NSCLC) progression. CAFs and normal (NFs) were isolated identified. Exosomes secreted from NFs analyze their effects on volume epithelial-mesenchymal transition (EMT). Exosomal expression level measured. The UPF1 viability, EMT, PTEN/PI3K/AKT...
Cancer-associated fibroblasts (CAFs) play crucial roles in enhancing cell survival, proliferation, invasion, and metastasis.We previously showed that hepatocellular carcinoma-derived CAFs (H-CAFs) promoted proliferation of carcinoma (HCC) cells.This study aimed to further explore the role HCC epithelial-mesenchymal transition (EMT) underlying mechanism.High CAF density was significantly associated with liver cirrhosis, inferior clinicopathologic characteristics, elevated EMT-associated...
Hyperphosphatemia is associated with cardiovascular morbidity and mortality in patients receiving maintenance dialysis. It unknown whether combining two therapies different mechanisms of action-tenapanor, an inhibitor paracellular phosphate absorption, binders-is safe effective for the management hyperphosphatemia dialysis.This double-blind phase 3 trial enrolled 236 undergoing dialysis (defined this as serum phosphorus 5.5-10 mg/dl inclusive) despite binder therapy (sevelamer, nonsevelamer,...
Cutaneous warts caused by human papillomavirus are benign proliferative lesions that occur at any ages in lives. Updated, comprehensive and systematic evidence-based guidelines to guide clinical practice urgently needed.We collaborated with multidisciplinary experts formulate this guideline based on evidences of already published literature, focusing 13 questions elected a panel experts. We adopted Grading Recommendations Assessment, Development Evaluation (GRADE) system form classification...
Bone marrow mesenchymal stromal cell-derived exosomes (BMSC-Exos) can recruit stem cells for bone repair, with neovessels serving as the main migratory channel to injury site. However, existing exosome (Exo) delivery strategies cannot reach angiogenesis phase following injury. To that end, an enzyme-sensitive Exo material responds neovessel formation during was designed in present study achieve spatiotemporally controlled release. Herein, matrix metalloproteinase-1 (MMP1) found be highly...
Abstract Everolimus is a kind of mammalian target rapamycin (mTOR) inhibitors. Activated mitogen-activated protein kinase interacting kinases/eukaryotic translation initiation factor 4E (MNK/eIF4E) axis plays crucial role in resistance to non-small cell lung cancer (NSCLC). The eIF4E phosphorylation increased by mTOR inhibitors mainly mediated MNKs. However, the mechanisms are poorly understood. Recently, extensive reprogramming miRNA profiles has also been found after long-term inhibitor...