A5101503997- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Microfluidic and Bio-sensing Technologies
- Cancer Cells and Metastasis
- 3D Printing in Biomedical Research
- Extracellular vesicles in disease
- Coastal wetland ecosystem dynamics
- Coastal and Marine Dynamics
- Single-cell and spatial transcriptomics
- Plasmonic and Surface Plasmon Research
- SARS-CoV-2 detection and testing
- Nanopore and Nanochannel Transport Studies
- MicroRNA in disease regulation
- Laser-induced spectroscopy and plasma
- Human Motion and Animation
- Blockchain Technology Applications and Security
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanoplatforms for cancer theranostics
- Oil Spill Detection and Mitigation
- Ocular and Laser Science Research
- Laser Material Processing Techniques
- Adipose Tissue and Metabolism
- Cybercrime and Law Enforcement Studies
Jewish General Hospital
2024
Jiangsu University
2023-2024
McGill University
2024
Sun Yat-sen University
2017-2023
Key Laboratory of Guangdong Province
2022
University of Tasmania
2022
Sun Yat-sen Memorial Hospital
2020
Third Affiliated Hospital of Sun Yat-sen University
2017-2020
Guangzhou University
2010
As a cause of postoperative complications and early hepatic failure after liver transplantation, ischemia/reperfusion injury (IRI) still has no effective treatment during clinical administration. Although the therapeutic potential mesenchymal stem cells (MSCs) for IRI been previously shown, underlying mechanisms are not completely clear. It is accepted that MSC-derived extracellular vesicles (MSC-EVs) newly uncovered messengers intercellular communication. Herein, it reported umbilical...
Surface proteins of cells are generally recognized through receptor–ligand interactions (RLIs) in disease diagnosis, but their nonuniform spatial distribution and higher-order structure lead to low binding affinity. Constructing nanotopologies that match the membrane improve affinity remains a challenge. Inspired by multiantigen recognition immune synapses, we developed modular DNA-origami-based nanoarrays with multivalent aptamers. By adjusting valency interspacing aptamers, constructed...
Abstract The capture and analysis of circulating tumor cells (CTCs) have provided a non‐invasive entry for cancer diagnosis disease monitoring. Despite recent development in affinity‐based CTCs isolation, it remains challenging to achieve efficient toward with dynamic surface expression. Enlightened by the synergistic effect insideimmune synapses, nanointerface engineered topology‐defined anisotropic aptamers programmed DNA scaffold (DNA nanosynapse), accurate is herein reported. As compared...
Exosomes derived from human umbilical cord mesenchymal stem cells (hucMSCs) expressing microRNAs (miRNAs) have been highlighted in cancers. However, the detailed molecular mechanism of hucMSCs-derived exosomal miR-451a on hepatocellular carcinoma (HCC) remains further investigation. Our study aims to explore impact progression HCC. Expression and a disintegrin metalloprotease 10 (ADAM10) HCC tissues adjacent normal were determined. The exosomes extracted hucMSCs co-cultured with Hep3B...
Multimeric aptamers have gained more attention than their monomeric counterparts due to providing binding sites for target analytes, leading increased affinity. This work attempted engineer the surface-based generation of multimeric by employing room temperature rolling circle amplification (RCA) technique and chemically modified primers developing a highly sensitive selective electrochemical aptasensor. The aptamers, generated through surface RCA, are hybridized spacer primers, facilitating...
Circulating tumor cells (CTCs) are noninvasive biomarkers with great potential for assessing neoplastic diseases. However, the enrichment bias toward heterogeneous CTCs remains to be minimized. Herein, a DNAzyme-catalyzed proximal protein biotinylation (DPPB) strategy is established unbiased enrichment, employing DNA-framework-based, aptamer-coupled DNAzymes that bind surface marker of and subsequently biotinylated membrane proteins in situ. The DNA framework enables construction multivalent...
Rationale: Hibernating thirteen-lined ground squirrels (GS; Ictidomys tridecemlineatus) are naturally adapted to prolonged periods of ultraprofound hypothermia (body temperature < 5 °C) during torpor, and drastic oscillations body ischemia/reperfusion-like stress their short euthermic interbout arousals.Thus, superior adaptability may hold tremendous promise for the advancement donor organ cold preservation subsequent transplantation.However, bridging hibernation research translational...
Abstract Multimeric aptamers have gained more attention than their monomeric counterparts due to providing binding sites for target analytes, leading increased affinity. This work attempted engineer the surface‐based generation of multimeric by employing room temperature rolling circle amplification (RCA) technique and chemically modified primers developing a highly sensitive selective electrochemical aptasensor. The aptamers, generated through surface RCA, are hybridized spacer primers,...
Abstract Efforts have been taken to enhance the study of single‐cells, however, task remains challenging because most previous investigations cannot exclude interactions between single cells or separately retrieved with specificity for further analyses. Here, a single‐cell mobility analysis platform (SCM‐Chip) is developed that can not only real‐time monitor migration in independent niches but also selectively recover target one by one. The design each channel capture unit and an outlet...
Pore-forming proteins are an agent for attack or defense in various organisms, and its cytolytic activity has medical potential cancer therapy. Despite recent advances mimicking these by amphipathic DNA nanopores, it remains inefficient to incorporate them into lipid bilayers. Here, we present the development of vesicular nanopores that can controllably open a membrane. Different from previously reported randomly insert planar bilayers, design on-command fusogenic liposome-incorporated...
Laser cleaning technology can solve the problem of removing silicon nitride from surface a graphite boat. This improvement enhances conversion efficiency and production crystalline solar cells.Real-time monitoring is an important component laser automation. Laser-Induced Breakdown Spectroscopy (LIBS) based on Beluga Whale Optimization (BWO) proposed for real-time analysis states boats in this paper. Compared to traditional ELM classification algorithm, which has inherent randomness, accuracy...
The data scarcity problem is a crucial factor that hampers the model performance of IMU-based human motion capture. However, effective augmentation for capture challenging, since it has to physical relations and constraints body, while maintaining distribution quality. We propose PoseAugment, novel pipeline incorporating VAE-based pose generation optimization. Given sequence, VAE module generates infinite poses with both high fidelity diversity, keeping distribution. optimizes satisfy...
The rapid development of digital economy has led to the emergence various black and shadow internet industries, which pose potential risks that can be identified managed through risk management (DRM) uses different techniques such as machine learning deep learning. evolution DRM architecture been driven by changes in data forms. However, AI-generated content (AIGC) technology, ChatGPT Stable Diffusion, given industries powerful tools personalize generate realistic images conversations for...
Abstract Surface proteins of cells are generally recognized through receptor-ligand interactions (RLIs) in disease diagnosis, but their nonuniform spatial distribution and high-order structure lead to low binding-affinity. Constructing nano-topologies that match the membrane improve binding-affinity remains a challenge. Inspired by multi-antigen recognition immune synapses, we developed modular DNA-origami-based nanoarrays with multivalent aptamers. By adjusting valence inter-spacing...
In the coastal ecological project aimed at wave attenuation through mangroves, incorporating oyster reefs as a complementary component to establish an “oyster + mangrove” system could enhance survival probability of mangrove, well improve overall effectiveness dissipation. This study investigates this innovative combined consisting and mangroves with various configurations. Laboratory experiments were conducted in flume using artificial models mangrove examine impact on effect, thereby...