A5054977676- Advanced biosensing and bioanalysis techniques
- Advanced Proteomics Techniques and Applications
- Biosensors and Analytical Detection
- Structural Engineering and Vibration Analysis
- Ubiquitin and proteasome pathways
- Metabolomics and Mass Spectrometry Studies
- RNA Interference and Gene Delivery
- Mass Spectrometry Techniques and Applications
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Gold and Silver Nanoparticles Synthesis and Applications
- MicroRNA in disease regulation
- Molecular Biology Techniques and Applications
- Ocular Diseases and Behçet’s Syndrome
- Advanced Nanomaterials in Catalysis
- Retinal and Optic Conditions
- Analytical Methods in Pharmaceuticals
- Nanoplatforms for cancer theranostics
- Vasculitis and related conditions
- Thermal Regulation in Medicine
- Micro and Nano Robotics
- Mechanical stress and fatigue analysis
- Extracellular vesicles in disease
- Autophagy in Disease and Therapy
- Forensic Fingerprint Detection Methods
Qingdao Municipal Hospital
2019-2025
Qingdao University
2019-2025
First Affiliated Hospital of Anhui Medical University
2025
Anhui Medical University
2025
University of Science and Technology of China
2023-2025
Fudan University
2010-2024
Hefei University of Technology
2021-2024
China Jiliang University
2022-2024
Huashan Hospital
2016-2024
Shanxi Medical University
2023-2024
Highlights•Tranilast-induced deacetylating LKB1 acts as a critical brake on hepatic lipid response.•LKB1-AMPK axis is essential for the inhibitory effects of tranilast response.•LKB1 acetylation potential intrinsic strategy NAFLD.•Tranilast serves novel drug candidate metabolic diseases.AbstractNonalcoholic fatty liver disease (NAFLD) progressive condition characterized by ectopic fat accumulation in liver, which no FAD-approved drugs currently exist. Emerging evidence highlights role kinase...
Background Previous work has shown reduced expression levels of let-7 in lung tumors. But little is known about the or mechanisms let-7a prostate cancer. In this study, we used vitro and vivo approaches to investigate whether E2F2 CCND2 are direct targets let-7a, if acts as a tumor suppressor cancer by down-regulating CCND2. Methodology/Principal Findings Real-time RT-PCR demonstrated that decreased present resected samples cell lines. Cellular proliferation was inhibited PC3 cells LNCaP...
Search for traces: Aptamer-bound Au nanoparticles (Au NPs) were used to provide high-resolution dark-field microscopy images of latent fingerprints (LFPs) with level 2 and 3 details. Furthermore, the cocaine-induced aggregation NPs results in a true green-to-red color change scattered light, providing quasi-quantative method identify cocaine loadings LFPs.
Plasmonic imaging under a dark-field microscope (DFM) holds great promise for single-particle analysis in bioimaging, nanophotonics, and nanocatalysis. Here, we designed DNA-directed programmable assembly strategy to fabricate halo-like Au nanostructure (nanohalo) that couples plasmonic large gold nanoparticles (L-AuNPs) with catalytically active small AuNPs (S-AuNPs) single nanoarchitecture. Catalytic reaction occurring on S-AuNPs changes its permittivity, which results significant...
Abstract It is highly demanding to design active nanomotors that can move in response specific signals with controllable rate and direction. A catalysis‐driven nanomotor was constructed by designing catalytically plasmonically Janus gold nanoparticles (Au NPs), which generate an asymmetric temperature gradient of local solvent surrounding NPs catalytic reactions. The self‐thermophoresis behavior the monitored from its inherent plasmonic response. diffusion coefficient motion linearly...
To investigate the neuroprotective mechanism of mild hypothermia (MH) in ameliorating cerebral ischemia reperfusion (IR) injury. The Pulsinelli's four-vessel ligation method was utilized to establish a rat model global IR role S100A8 MH treatment injury, hippocampus-specific loss or gain function achieved using an adeno-associated virus system. We examined effect over-expression knock-down on SH-SY5Y cell line subjected oxygen-glucose deprivation reoxygenation (OGDR) injury under and delved...
Cellular imaging technologies employing metallic surface-enhanced Raman scattering (SERS) tags have gained much interest toward clinical diagnostics, but they are still suffering from poor controlled distribution of hot spots and reproducibility SERS signals. Here, we report the fabrication characterization high narrow nanogap-containing Au@Au core-shell nanoparticles (GCNPs) for identification proteins overexpressed on surface cancer cells. First, plasmonic nanostructures made gold (∼15 nm)...
Abstract The capture and analysis of circulating tumor cells (CTCs) have provided a non‐invasive entry for cancer diagnosis disease monitoring. Despite recent development in affinity‐based CTCs isolation, it remains challenging to achieve efficient toward with dynamic surface expression. Enlightened by the synergistic effect insideimmune synapses, nanointerface engineered topology‐defined anisotropic aptamers programmed DNA scaffold (DNA nanosynapse), accurate is herein reported. As compared...
Lysosomes play a critical role in the autophagy process. The impairment of lysosomes can affect degradation autophagic cargo, leading to blockage at lysosomal stage and subsequent cell death. Herein, two phosphorescent Re(i) tricarbonyl complexes (Re1 Re2) bearing β-carboline derivatives have been synthesized characterized. Both show pH-dependent phosphorescence, which be used specifically image lysosomes. Cytotoxicity assay shows that they exhibit high anticancer activity are able overcome...
The potency of two anticancer iridium-based molecular compounds was greatly enhanced under light irradiation.
Background Non-alcoholic fatty liver disease (NAFLD) is independently associated with atrial fibrillation (AF) risk. The uric acid (UA) to high-density lipoprotein cholesterol (HDL-C) ratio (UHR) has been shown be closely cardiovascular (CVD) and NAFLD. aim of this study clarify whether elevated UHR the occurrence AF in patients NAFLD determine predicted AF. Methods Patients diagnosed Department Cardiovascular Medicine Second Hospital Shanxi Medical University from January 1, 2020, December...
Matrix metalloproteinases (MMPs) have been involved in inflammatory and degradative processes pathologic conditions. The purpose of this study was to investigate the protective effect melatonin human umbilical vein endothelial cell (HUVEC) monolayer permeability regulation MMP9 induced by interleukin 1β (IL1β (IL1B)) HUVECs. Protection studies were carried out with melatonin, a well-known antioxidant antiinflammatory molecule. expression increased IL1β induction Melatonin showed...
Although tamoxifen (TAM), a selective estrogen receptor modulator, has been widely used in the treatment of hormone-responsive breast cancer, its estrogen-like effect increases risk endometrial cancer. However, molecular mechanisms TAM-induced carcinoma still remain unclear. In this report, we explored role microRNAs (miRNAs) epithelial-mesenchymal transition (EMT) ECC-1 and Ishikawa cancer cell lines found miR-200 is involved process via regulation c-Myc. When treated with TAM, cells were...
Explosive detection is a critical element in preventing terrorist attacks, especially crowded and influential areas. It probably more important to establish the connection of explosive loading with carrier's personal identity. In present work, we introduce fingerprinting as physical identification develop nondestructive nanoplasmonic method for imaging latent fingerprints. We further integrate response catalytic growth Au NPs NADH-mediated reduction 1,3,5-trinitro-1,3,5-triazinane (RDX)...
// Wei Wang 1, * , Gang Ji 2, Xin Xiao 3, Xu Chen 1 Wei-Wei Qin Fan Yang Yu-Fang Li Lin-Ni 4 Wen-Jin Xi Yi Huo Wei-Hong Wen An-Gang Tao 5 State Key Laboratory of Cancer Biology, Department Immunology, Fourth Military Medical University, Xi'an, Shaanxi, PR China 2 Digestive Diseases, Xijing Hospital, 3 Orthopedics, Pathology, Genetics and Developmental These authors have contributed equally to this work Correspondence to: Yang, email: agyang@fmmu.edu.cn Wang, wangt@fmmu.edu.cn Keywords:...