A5089857472- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Zebrafish Biomedical Research Applications
- Bladder and Urothelial Cancer Treatments
- Sexual function and dysfunction studies
- Renal cell carcinoma treatment
- Chronic Kidney Disease and Diabetes
- Ferroptosis and cancer prognosis
- Acute Kidney Injury Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Renal and related cancers
- Nanoplatforms for cancer theranostics
- Genetic and Kidney Cyst Diseases
- Angiogenesis and VEGF in Cancer
- Genetics, Aging, and Longevity in Model Organisms
- RNA modifications and cancer
- Healthcare and Venom Research
- Metabolism, Diabetes, and Cancer
- Venomous Animal Envenomation and Studies
- MicroRNA in disease regulation
- Radiopharmaceutical Chemistry and Applications
- Nuclear Receptors and Signaling
Guangzhou Medical University
2024
Southern Medical University
2012-2023
Air Force Medical University
2010-2023
Qilu Normal University
2023
Xijing Hospital
2010-2023
Tang Hospital
2023
Universiti Putra Malaysia
2023
Nanfang Hospital
2020-2022
Kunming Institute of Zoology
2015-2022
Yan'an Hospital Affiliated To Kunming Medical University
2019-2022
Breast cancer (BC) is the most prevalent malignant neoplasm among women and fifth common cause of cancer-associated death worldwide. Acquired chemoresistance driven by genetic epigenetic alterations a significant clinical challenge in treating BC. However, mechanism BC cell resistance to adriamycin (ADR) remains be elucidated. In this study, we identified methyltransferase-like 3/microRNA-221-3p/homeodomain-interacting protein kinase 2/Che-1 (METTL3/miR-221-3p/HIPK2/Che-1) axis as novel...
Background Previous work has shown reduced expression levels of let-7 in lung tumors. But little is known about the or mechanisms let-7a prostate cancer. In this study, we used vitro and vivo approaches to investigate whether E2F2 CCND2 are direct targets let-7a, if acts as a tumor suppressor cancer by down-regulating CCND2. Methodology/Principal Findings Real-time RT-PCR demonstrated that decreased present resected samples cell lines. Cellular proliferation was inhibited PC3 cells LNCaP...
As a new anti-diabetic medicine, Liraglutide (LIRA), one of GLP-1 analogues, has been found to have an anti-atherosclerotic effect. Since vascular smooth muscle cells (VSMCs) play pivotal roles in the occurrence diabetic atherosclerosis, it is important investigate role LIRA reducing harmful effects high-glucose (HG) treatment cultured VSMCs, and identifying associated molecular mechanisms.Primary rat VSMCs were exposed low or high glucose-containing medium with without LIRA. They challenged...
Abstract To address the shortcomings of cystoscopy and urine cytology for detecting grading bladder cancer (BC), ultrahigh performance liquid chromatography (UHPLC) coupled with Q-TOF mass spectrometry in conjunction univariate multivariate statistical analyses was employed as an alternative method diagnosis BC. A series differential serum metabolites were further identified low-grade(LG) high-grade(HG) BC patients, suggesting metabolic dysfunction malignant proliferation, immune escape,...
Nobiletin is a polymethoxy flavonoid isolated from Citrus depressa and reticulata. It has been reported that nobiletin can suppress tumors. We primarily explored the antitumor effects of associated potential mechanisms in ACHN Caki-2 renal carcinoma cells. A CCK-8 assay cloning experiments were used to assess cell viability, transwell scratch test metastatic ability. The cycle was analyzed by flow cytometry, whereas apoptosis using cytometry terminal dexynucleotidyl transferase...
Abstract Blood clot formation induced by dysfunctional coagulation is a frequent complication of coronavirus disease 2019 (COVID-19) and high-risk factor for severe illness death. Neutrophil extracellular traps (NETs) are implicated in COVID-19-induced immunothrombosis. Furthermore, human cathelicidin, NET component, can perturb the interaction between SARS-CoV-2 spike protein its ACE2 receptor, which mediates viral entry into cells. At present, however, levels cathelicidin antimicrobial...
Renal fibrosis is a common feature of various chronic kidney diseases. However, the underlying mechanism remains poorly understood. The CXC chemokine receptor (CXCR) family plays role in renal fibrosis; however, detailed mechanisms have not been elucidated. In this study, we investigated potential CXCR7 mediating fibrosis. expression decreased unilateral ischemia–reperfusion injury (UIRI) and ureteral obstruction mouse models. Furthermore, was specifically expressed primarily Lotus...
Acute kidney injury (AKI) is in rapid prevalence nowadays. Of note, the underlying mechanisms have not been clarified. Several reports showed a cluster of differentiation-44 (CD44), cell-surface glycoprotein, might be involved AKI. However, its role AKI has clearly Herein, we found CD44 increased renal tubules mice. Gene ablation improved mitochondrial biogenesis and fatty acid oxidation (FAO) function, further protecting against tubular cell death injury. Conversely, ectopic impaired...
Despite extensive research that has been carried out over the past three decades in field of renal ischaemia-reperfusion (I/R) injury, pathogenic role mitochondrial fission I/R injury is poorly understood. The aim our study to investigate molecular mechanism by which mammalian STE20-like kinase 1 (Mst1) participates through modifying fission, microtubule cytoskeleton dynamics, and GSK3β-p53 signalling pathway. Our data demonstrated genetic ablation Mst1 improved function, alleviated...
Abstract The study was aimed at assessing the diagnostic performance of 68 Ga-PSMA-617 PET/CT in detection prostate cancer (PCa) patients with a prostate-specific antigen (PSA) level 4–20 ng/ml and to compare its efficacy that multiparametric MRI (mpMRI). We analyzed data 67 consecutive PSA levels who almost simultaneously underwent mpMRI. mpMRI performances were compared via receiver operating characteristic (ROC) curve analysis. Of suspected PCa cases, 33 had pathologically confirmed PCa....
Background: Liver kinase B1 (LKB1) is the key regulator of energy metabolism and cell homeostasis.LKB1 dysfunction plays a role in renal fibrosis.However, LKB1 activators are scarce commercial nowadays.This study aims to discover new drug molecule, piericidin analogue S14 (PA-S14), preventing fibrosis as novel activator LKB1.Methods: Our group isolated PA-S14 from broth culture marine-derived Streptomyces strain identified its binding site.We adopted various CKD models or AKI-CKD model (5/6...
The detection of tumor markers has significant importance in the early diagnosis cancer. It is an important indicator for evaluating extent disease and monitoring efficacy treatment. Therefore, it meaningful to find a convenient, fast, sensitive method detect markers. Carbohydrate antigen 19–9 (CA19-9) first discovered carbohydrate marker with highest sensitivity specificity pancreatic Carcinoembryonic (CEA), as most widely spectrum marker, can show upward trend many tumors. In this work,...
Antimicrobial peptides have been widely identified from amphibian skins except salamanders. A novel antimicrobial peptide (CFBD) was isolated and characterized skin secretions of the salamander, Cynops fudingensis. The cDNA encoding CFBD precursor cloned library C. composed three domains: signal 17 residues, mature 41 residues intervening propeptide 3 residues. There are six cysteines in sequence peptide, which possibly form disulfide-bridges. showed activities against Staphylococcus aureus,...
Abstract Controversies exist between the previous two prognostic nomograms for patients with bone metastatic prostate cancer (PCa), and a nomogram applied to western has yet be established. Thus, we aimed build reliable generic individualize prognosis. The independent factors were identified in retrospective study of 1556 PCa registered Surveillance, Epidemiology End Results (SEER) database. Besides, was developed using R software according result multivariable Cox regression analysis. Then,...
Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer have a higher dependency on molecular chaperones maintain proteostasis. The chaperonin T-complex protein ring complex (TRiC) contains eight paralogous subunits (CCT1-8), and assists folding as many 10% cytosolic proteome. TRiC essential for progression some cancers, but roles osteosarcoma remain be explored. Here, we show that CCT4/TRiC...
Chronic obstructive pulmonary disease (COPD) is underdiagnosed with the current gold standard measure function test (PFT). A more sensitive and simple option for early detection severity evaluation of COPD could benefit practitioners patients.
Abstract Kidney is one of the most important organs in maintaining normal life activities. With high abundance mitochondria, renal tubular cell plays vital role functioning reabsorption and secretion kidney. Reports have shown that mitochondrial dysfunction great importance to senescence subsequent kidney ageing. However, underlying mechanisms are not elucidated. Cannabinoid receptor 2 two receptors responsible for activation endocannabinoid system. CB2 primarily upregulated cells chronic...
Aging is an important risk factor for kidney injury. Energy homeostasis plays a key role in retarding aging, and mitochondria are responsible energy production. In the kidney, renal tubular cells possess high abundance of to meet consumption. AMPK evolutionarily conserved serine/threonine kinase which central maintaining mitochondrial homeostasis. Besides that, also commands autophagy, clearing recycling process maintain cellular However, effect activators on aging has not been fully...