A5100371533- Glioma Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- HIV Research and Treatment
- Hemophilia Treatment and Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Blood Coagulation and Thrombosis Mechanisms
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Psoriasis: Treatment and Pathogenesis
- DNA Repair Mechanisms
- Traditional Chinese Medicine Analysis
- Osteoarthritis Treatment and Mechanisms
- Pancreatic function and diabetes
- Spine and Intervertebral Disc Pathology
- Advanced Glycation End Products research
- RNA Interference and Gene Delivery
- Inflammasome and immune disorders
University of Science and Technology of China
2013-2025
Southern Medical University
2022-2025
Nanfang Hospital
2022-2025
Guilin Medical University
2025
Zhejiang Chinese Medical University
2025
Shanxi Medical University
2023-2025
Shaanxi Provincial People's Hospital
2025
Hebei Medical University
2022-2024
Fourth Hospital of Hebei Medical University
2022-2024
First Affiliated Hospital of Hebei Medical University
2022-2024
Significance The αβ T-cell receptor (TCR) on mammalian T lymphocytes recognizes intracellular pathogens to afford protective immunity. Detection of various foreign peptides bound MHC molecules as TCR ligands occurs during immune surveillance where mechanical forces are generated through cell movement. Using single-molecule optical tweezer assays, we show with isolated and complete receptors single cells that both sensitivity specificity the biological T-lymphocyte response is dependent upon...
Lysine succinylation is a new posttranslational modification identified in histone proteins of Toxoplasma gondii, an obligate intracellular parasite the phylum Apicomplexa. However, very little known about their scope and cellular distribution. Here, using LC–MS/MS to identify peptides enriched by immunopurification with succinyl lysine antibody, we produced first succinylome this parasite. Overall, total 425 sites that occurred on 147 succinylated were extracellular tachyzoites, which...
Temozolomide (TMZ) resistance in glioblastoma multiforme (GBM) is mediated by the DNA repair protein O6-methylguanine methyltransferase (MGMT). MGMT promoter methylation (occurs about 40% of patients) associated with loss expression (MGMT-) that compromises repair, leading to a favorable response TMZ therapy. The 60% patients unmethylated (MGMT+) GBM experience TMZ; these patients, understanding mechanism MGMT-mediated and modulating activity may lead enhanced activity. Here, we report novel...
Rationale: Renal fibrosis, with no therapeutic approaches, is a common pathological feature in various chronic kidney diseases (CKD).Tubular cell injury plays pivotal role renal fibrosis.Commonly, injured tubular cells exhibit significant lipid accumulation.However, the underlying mechanisms remain poorly understood.Methods: 2-arachidonoylglycerol (2-AG) levels CKD patients and model specimens were measured using mass spectrometry.2-AG-loaded nanoparticles infused into unilateral ureteral...
SLE and ME/CFS both present significant fatigue share immune dysregulation. The mechanisms underlying in these disorders remain unclear, there are no standardized treatments. This study aims to explore shared predict potential therapeutic drugs for ME/CFS. Genes associated with were collected from disease target clinical sample databases identify overlapping genes. Bioinformatics analyses, including GO, KEGG, PPI network construction, key identification, performed. ROC curve correlation...
Abstract Cytotoxic-T-lymphocyte (CTL) mediated control of HIV-1 is enhanced by targeting highly networked epitopes in complex with human-leukocyte-antigen-class-I (HLA-I). However, the extent to which presenting HLA allele contributes this process unknown. Here we examine CTL response QW9, a epitope presented disease-protective HLA-B57 and disease-neutral HLA-B53. Despite robust QW9 persons expressing either allele, T cell receptor (TCR) cross-recognition naturally occurring variant QW9_S3T...
Renal fibrosis is a common feature in various chronic kidney diseases (CKD). Tubular cell damage main characterization which results from dysregulated fatty acid oxidation (FAO) and lipid accumulation. Cannabinoid Receptor 2 (CB2) contributes to renal fibrosis, however, its role FAO dysregulation tubular cells not clarified. In this study, we found CB2 plays detrimental metabolism cells.
Bmal1 is a transcription factor that plays central role in the regulation of circadian rhythms. Recent study reported Bmal1-/- mice displayed many known features premature ageing, such as reduction bone mass. Our previous has found both proliferation marrow mesenchymal stem cells (BMSCs) and expression decreased with advancing age. It seemed positive correlation existed between protein level proliferative activity BMSCs. β-catenin, core canonical Wnt pathway, also showed reduced aged mice....
Chondral defects pose a great challenge for clinicians to manage owing the limited capacity self-healing. Various traditional approaches have been adopted repair of these with unsatisfactory results. Cartilage tissue engineering techniques emerged as promising strategies enhance regeneration and overcome shortcomings. The cell-homing based technique is considered most its unique advantages. Thermosensitive hydrogels applied scaffolds biomedical applications smart sol-gel response altering...
Self-discrimination, a critical but ill-defined molecular process programmed during thymocyte development, requires myriad pre-T cell receptors (preTCRs) and αβTCRs. Using x-ray crystallography, we show how preTCR applies the concave β-sheet surface of its single variable domain (Vβ) to "horizontally" grab protruding MHC α2-helix. By contrast, αβTCRs purpose all six complementarity-determining region (CDR) loops their paired VαVβ module recognize peptides bound major histocompatibility...
Acute kidney injury (AKI) is in rapid prevalence nowadays. Of note, the underlying mechanisms have not been clarified. Several reports showed a cluster of differentiation-44 (CD44), cell-surface glycoprotein, might be involved AKI. However, its role AKI has clearly Herein, we found CD44 increased renal tubules mice. Gene ablation improved mitochondrial biogenesis and fatty acid oxidation (FAO) function, further protecting against tubular cell death injury. Conversely, ectopic impaired...
Abstract Naturally evolved T-cell receptors (TCRs) exhibit remarkably high specificity in discriminating non-self antigens from self-antigens under dynamic biomechanical modulation. In contrast, engineered high-affinity TCRs often lose this specificity, leading to cross-reactivity with and off-target toxicity. The underlying mechanism for difference remains unclear. Our study reveals that natural exploit mechanical force form optimal catch bonds their cognate antigens. This process relies on...
Buzhong Yiqi Decoction (BZYQD) is a traditional Chinese medicine renowned for its anti-colorectal cancer (CRC) properties. However, the bioactive components and mechanisms of BZYQD against CRC remain unknown. In this study, LC-MS was used to analyze chemical composition BZYQD. Next, network pharmacology molecular docking investigate core targets CRC. Finally, we experimentally validated potential mechanism through in vitro studies. Our results identified 26 BZYQD; 75 "hithubs" were screened...