A5006030795- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Cell Adhesion Molecules Research
- Glycosylation and Glycoproteins Research
- Genetics, Bioinformatics, and Biomedical Research
- HIV Research and Treatment
- Immunotherapy and Immune Responses
- Axon Guidance and Neuronal Signaling
- CAR-T cell therapy research
- Angiogenesis and VEGF in Cancer
- Cellular Mechanics and Interactions
- Biochemical and Structural Characterization
- Bacteriophages and microbial interactions
- RNA and protein synthesis mechanisms
- Immune Response and Inflammation
- Influenza Virus Research Studies
- earthquake and tectonic studies
- Galectins and Cancer Biology
- Transgenic Plants and Applications
- Protein Structure and Dynamics
- Hippo pathway signaling and YAP/TAZ
- Enzyme Structure and Function
- Signaling Pathways in Disease
- Machine Learning in Bioinformatics
Dana-Farber Cancer Institute
2014-2023
Harvard University
2014-2023
Peking University
2012-2019
Jilin Academy of Agricultural Sciences
2017
University of Science and Technology of China
2013-2016
Beijing Haidian Hospital
2014
Capital Medical University
2014
Beijing Academy of Food Sciences
2012
Institute of Earth Sciences, Academia Sinica
2012
Boston University
2003-2011
The crystal structure of a complex involving the D10 T cell receptor (TCR), 16-residue foreign peptide antigen, and I-Ak self major histocompatibility (MHC) class II molecule is reported at 3.2 angstrom resolution. TCR oriented in an orthogonal mode relative to its peptide-MHC (pMHC) ligand, necessitated by amino-terminal extension residues projecting from MHC antigen-binding groove as part mini beta sheet. Consequently, disposition complementarity-determining region loops altered that most...
Significance The αβ T-cell receptor (TCR) on mammalian T lymphocytes recognizes intracellular pathogens to afford protective immunity. Detection of various foreign peptides bound MHC molecules as TCR ligands occurs during immune surveillance where mechanical forces are generated through cell movement. Using single-molecule optical tweezer assays, we show with isolated and complete receptors single cells that both sensitivity specificity the biological T-lymphocyte response is dependent upon...
Thrombospondin-1 (TSP-1) contains three type 1 repeats (TSRs), which mediate cell attachment, glycosaminoglycan binding, inhibition of angiogenesis, activation TGFβ, and matrix metalloproteinases. The crystal structure the TSRs reported in this article reveals a novel, antiparallel, three-stranded fold that consists alternating stacked layers tryptophan arginine residues from respective strands, capped by disulfide bonds on each end. front face TSR right-handed spiral, positively charged...
BackgoundThe CD40 ligand (CD40L) is a member of the tumor necrosis factor (TNF) family proteins and transiently expressed on surface activated T cells. The binding CD40L to CD40, which B cells, provides critical unique pathway cellular activation resulting in antibody isotype switching, regulation apoptosis, cell proliferation differentiation. Naturally occurring mutations result clinical hyper-IgM syndrome, characterized by an inability produce immunoglobulins IgG, IgA IgE...
The structural basis of the interaction between CD4 coreceptor and a class II major histocompatibility complex (MHC) is described. crystal structure containing human N-terminal two-domain fragment murine I-A(k) MHC molecule with associated peptide (pMHCII) shows that only "top corner" directly contacts pMHCII. Phe-43 side chain extends into hydrophobic concavity formed by residues from both alpha 2 beta domains. A ternary model CD4-pMHCII-T-cell receptor (TCR) reveals appears V-shaped...
The 3.0-A structure of a 190-residue fragment intercellular adhesion molecule-1 (ICAM-1, CD54) reveals two tandem Ig-superfamily (IgSF) domains. Each independent molecules dimerizes identically with symmetry-related molecule over hydrophobic interface on the BED sheet domain 1, in agreement dimerization ICAM-1 cell surface. residues that bind to integrin LFA-1 are well oriented for bivalent binding dimer, critical Glu-34 pointing away from each other periphery. Residues rhinovirus flexible...
During development, tissue repair, and tumor growth, most blood vessel networks are generated through angiogenesis. Vascular endothelial growth factor (VEGF) is a key regulator of this process currently both VEGF its receptors, VEGFR1, VEGFR2, Neuropilin1 (NRP1), targeted in therapeutic strategies for vascular disease cancer. NRP1 essential morphogenesis, but how functions to guide development has not been completely elucidated. In study, we mouse line harboring point mutation the endogenous...
This study evaluated the effects of Bacillus fermentation on soybean meal protein (SBMP) microstructure and major anti-nutritional factors (ANFs) in (SBM). The siamensis isolate JL8 producing high yield protease at 519·1 U g-1 was selected for laboratory production fermented (FSBM). After 24 h fermentation, FSBM showed better properties compared with those SBM, ANFs such as glycinin, β-conglycinin trypsin inhibitor significantly decreased by 86·0, 70·3 95·01%, while vitro digestibility...
A vaccine capable of stimulating protective antiviral antibody responses is needed to curtail the global AIDS epidemic caused by HIV-1. Although rarely elicited during course natural infection or upon conventional vaccination, membrane-proximal ectodomain region (MPER) HIV-1 glycoprotein M r 41,000 (gp41) envelope protein subunit target 3 such human broadly neutralizing antibodies (BNAbs): 4E10, 2F5, and Z13e1. How these BNAbs bind their lipid-embedded epitopes mediate activity unclear, but...
Significance The thymus generates the repertoire of disease-fighting T lymphocytes, affording lifelong host protection against infectious organisms and other pathogens. To achieve this goal, a microinductive environment converts precursors into millions distinct functional cells. Because each lineage cell displays clone-specific T-cell receptor (TCR) that is generated through stochastic (i.e., haphazard) recombination events, specificities thymocytes must be interrogated, those expressing...