A5100719733- Chemical Synthesis and Analysis
- Click Chemistry and Applications
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Catalytic C–H Functionalization Methods
- Software-Defined Networks and 5G
- Catalytic Cross-Coupling Reactions
- Sulfur-Based Synthesis Techniques
- RNA and protein synthesis mechanisms
- Synthesis and Catalytic Reactions
- Mobile Agent-Based Network Management
- IPv6, Mobility, Handover, Networks, Security
- DNA and Nucleic Acid Chemistry
- Cyclopropane Reaction Mechanisms
- Distributed and Parallel Computing Systems
- Cloud Computing and Resource Management
- Carbohydrate Chemistry and Synthesis
- Adipose Tissue and Metabolism
- CRISPR and Genetic Engineering
- Distributed systems and fault tolerance
- Sirtuins and Resveratrol in Medicine
- Advanced Photocatalysis Techniques
- Metal-Organic Frameworks: Synthesis and Applications
- Cancer Genomics and Diagnostics
- Advanced Nanomaterials in Catalysis
Chongqing University
2018-2025
People's Hospital of Xinjiang Uygur Autonomous Region
2025
Peking University
2007-2025
Center for Life Sciences
2024-2025
Beijing National Laboratory for Molecular Sciences
2007-2024
Sichuan University
2009-2024
Northwest A&F University
2021-2024
Chemical Synthesis Lab
2022-2024
Tokyo Institute of Technology
2022-2024
Northwest Normal University
2024
No compass required: A method is described for forming biaryl CC bonds by a PdII-catalyzed cross-coupling of aryl CH with boronic acids under mild conditions without the presence directing groups. Different substituents on both (hetero)arenes and are compatible reaction conditions, homocoupling highly inhibited. Dioxygen was applied as final oxidant. Supporting information this article available WWW http://www.wiley-vch.de/contents/jc_2002/2008/z704619_s.pdf or from author. Please note:...
Highly regioselective olefination of substituted N,N-dimethylbenzylamines was developed by tuning the acidity reaction conditions based on analysis their features. The ortho-functionalized were further transformed into 3-(2‘-tolyl)propanoic acid and its derivatives under mild conditions. These two transformations could be combined one pot, obtained in moderate to good yields. Mechanistic studies indicated that electrophilic attack phenyl ring Pd(II) ion assisted N,N-dimethylaminomethyl group...
Hooking up: FeCl(2) catalyzes the efficient cross dehydrogenative arylation of substrates having benzylic C-H bonds (see scheme). High regioselectivity was observed during cross-coupling between compounds containing aromatic C(sp(2))-H and C(sp(3))-H bonds. This process is proposed to proceed by single-electron-transfer oxidation Friedel-Crafts alkylation.
Abstract Flexible and lightweight supercapacitors with superior mechanical flexibility outstanding capacity are regarded as an ideal power source for wearable electronic devices. Meanwhile, incorporating additional novel characters such transparency electrochromism can further benefit the development of smart supercapacitors. Nevertheless, application commonly used planar‐structural current collectors is seriously restricted by their intrinsic properties poor rigidity, large thickness,...
Bioconjugation chemistry has emerged as a powerful tool for the modification of diverse biomolecules under mild conditions. Tetrazole, initially proposed bioorthogonal photoclick handle 1,3-dipolar cyclization with alkenes, was later demonstrated to possess broader photoreactivity carboxylic acids, serving versatile bioconjugation and photoaffinity labeling probe. In this study, we unexpectedly discovered validated between tetrazole primary amine afford new 1,2,4-triazole product. Given...
Finding the right partner: The catalyst system [NiCl2(PCy3)2] mediates title transformation with high efficiency and allows aryl–aryl vinyl–aryl coupling to proceed. first example of catalytic cross-coupling using pivalates organozinc reagents is described (see scheme; Cy=cyclohexyl, piv=pivalate). Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors....
The CRISPR-Cas9 targeted nuclease technology allows the insertion of genetic modifications with single base-pair precision. preference mammalian cells to repair Cas9-induced DNA double-strand breaks via error-prone end-joining pathways rather than homology-directed mechanisms, however, leads relatively low rates precise editing from donor DNA. Here we show that spatial and temporal co-localization template Cas9 covalent linkage increases correction up 24-fold, demonstrate effect is mainly...
Abstract The selection of DNA‐encoded libraries against biological targets has become an important discovery method in chemical biology and drug discovery, but the requirement modified immobilized remains a significant disadvantage. With terminal protection strategy ligand‐induced photo‐crosslinking, we show that iterated selections can be realized with unmodified non‐immobilized protein targets.
DNA-encoded combinatorial libraries are increasingly being used as tools for the discovery of small organic binding molecules to proteins biological or pharmaceutical interest. In majority cases, synthetic procedures formation incorporate at least one step amide bond between amino-modified DNA and a carboxylic acid. We investigated reaction conditions established methodology by using 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide, 1-hydroxy-7-azabenzotriazole N,N'-diisopropylethylamine...
Abstract The dysfunction of the circulatory system leads to various pathological processes with high morbidity. Recently, fluorescence imaging in near‐infrared II (NIR‐II) window (1000–1700 nm) has attracted immense attention many biological processes. rapid metabolism and low toxicity some NIR‐II organic small molecules indicate their feasibility for use visualizing system. However, most reported presently encounter such dilemmas as complicated synthetic procedures quantum yields (QY). To...
Complexation of achiral pillar[5]arenes with chiral amines induced strong circular dichroism (CD) signals. The CD responses differed drastically depending on the nature amino acid guest, and they significantly varied part them even inverted, upon increasing length alkyl chains guests. Accordingly, this tactic allowed for unprecedented simultaneous enantiomeric structural differentiation α-amino esters homologous molecular hosts.
Abstract Oxidative Kupplung : FeCl 2 katalysiert die effiziente dehydrierende Arylierung von Substraten mit benzylischen C‐H‐Bindungen (siehe Schema). Die Kreuzkupplungen zwischen Verbindungen aromatischen C(sp )‐H‐Bindungen und 3 verliefen hoch regioselektiv. Reaktion könnte über eine Einelektronenoxidation anschließender Friedel‐Crafts‐Alkylierung ablaufen. magnified image
In vertebrates, hematopoiesis occurring in different niches is orchestrated by intrinsic and extrinsic regulators. Previous studies have revealed numerous linear planar regulatory mechanisms. However, a multi-dimensional transcriptomic atlas of any given hematopoietic organ has not yet been established. Here, we use multiple RNA sequencing (RNA-seq) approaches, including cell type-specific, temporal bulk RNA-seq, vivo GEO-seq, single-cell RNA-seq (scRNA-seq), to characterize the detailed...
Single image deraining is typically addressed as residual learning to predict the rain layer from an input rainy image. For this purpose, encoder-decoder network draws wide attention, where encoder required encode a high-quality embedding which determines performance of subsequent decoding stage reconstruct layer. However, most existing studies ignore significance quality, thus leading limited with over/under-deraining. In paper, our observation high reconstruction by rain-to-rain...
DNA-compatible direct oxidative coupling using various sulfur/selenium sources has been achieved, featuring pre-functionalization-free substrates and transition metal-free condition.
The incorporation of the isoindole core into DNA-encoded chemical library is highly desirable for great potential pharmacological characters exampled by molecules like lenalidomide. Herein, we reported a DNA-compatible protocol OPA-mediated transformation amines drug-like moieties represented isoindolinone and thio-2-isoindole, respectively. high conversion wide substrate-scope property our render its feasibility in manipulation terminal on oligonucleotide conjugates, including...