A5053465114- Supramolecular Chemistry and Complexes
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Crystallography and molecular interactions
- Photochromic and Fluorescence Chemistry
- Porphyrin and Phthalocyanine Chemistry
- Metal-Organic Frameworks: Synthesis and Applications
- Supramolecular Self-Assembly in Materials
- Nanoparticle-Based Drug Delivery
- Radical Photochemical Reactions
- Photodynamic Therapy Research Studies
- Molecular spectroscopy and chirality
- Nanoplatforms for cancer theranostics
- Polydiacetylene-based materials and applications
- RNA Interference and Gene Delivery
- Simulation and Modeling Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Analytical Chemistry and Chromatography
- Image Processing and 3D Reconstruction
- Photoreceptor and optogenetics research
- Fullerene Chemistry and Applications
- Synthesis and Properties of Aromatic Compounds
- Dendrimers and Hyperbranched Polymers
Zhejiang Medicine (China)
2023
Sichuan University
2011-2023
State Key Laboratory of Biotherapy
2018-2022
East China University of Science and Technology
2019
State Council of the People's Republic of China
2019
West China Hospital of Sichuan University
2019
Green Chemistry
2019
Chengdu University
2018
A chiral electrochemically responsive molecular universal joint (EMUJ) was synthesized by fusing a macrocyclic pillar[6]arene (P[6]) to ferrocene-based side ring. single crystal of an enantiopure EMUJ successfully obtained, which allowed, for the first time, definitive correlation between absolute configuration and circular dichroism spectrum P[6] derivative be determined. The self-inclusion self-exclusion conformational change led chiroptical inversion moiety, could manipulated both...
Abstract Stimuli-responsive intelligent molecular machines/devices are of current research interest due to their potential application in minimized devices. Constructing capable accomplishing complex missions is challenging, demanding coalescence various functions into one molecule. Here we report the construction chiroptical photoswitches based on azobenzene-fused bicyclic pillar[ n ]arene derivatives, which defined as universal joints (MUJs). The Z / E photoisomerization azobenzene moiety...
Complexation of achiral pillar[5]arenes with chiral amines induced strong circular dichroism (CD) signals. The CD responses differed drastically depending on the nature amino acid guest, and they significantly varied part them even inverted, upon increasing length alkyl chains guests. Accordingly, this tactic allowed for unprecedented simultaneous enantiomeric structural differentiation α-amino esters homologous molecular hosts.
Visible-light-driven enantiodifferentiating photodimerization of 2-anthracenecarboxylic acid (AC) sensitized by Schiff base Pt(II) complex-grafted γ-cyclodextrins leads the first triplet–triplet annihilation-based catalytic photochirogenesis. The syn-head-to-tail (HT) photodimer 2 was achieved in up to 31.4% ee at 61.0% conversion presence 0.5% equiv photocatalyst.
Unprecedented interheteromacrocyclic hosts charge transfer (CT) crystals were generated by cooling organic solutions containing p-dimethoxybenzene-constituted pillar[5]arene (P5A) and p-benzoquinone-constituted pillar[5]quinone (P5Q). Despite the weak CT interaction known between p-dimethoxybenzene p-benzoquinone lack of formation complexes P5A P5Q in solution phase, cocrystals formed with solvent molecules included into hosts' cavities. Such a cocrystallization arises from an elegant...
Planar chiral cyclophanopillar[5]arenes with a fused oligo(oxyethylene) or polymethylene subring (MUJs), existing as an equilibrium mixture of subring-included (in) and -excluded (out) conformers, respond to hydrostatic pressure exhibit dynamic chiroptical property changes, leading unprecedented pressure-driven chirality inversion the largest ever-reported leap anisotropy (g) factor for MUJ dodecamethylene subring. The susceptivity MUJs, assessed by change in g per unit pressure, is critical...
Mixing γ-cyclodextrin (γ-CD), cucurbit[6]uril (CB[6]) and tetraammonium-bearing axles together led to a spontaneous formation of γ-CD-CB[6]-cowheeled [4]pseudorotaxanes. The well-defined unsymmetrical cavities thus formed enhance the binding affinity towards chiral amines by factors several hundreds show remarkably improved discrimination.
A bicyclic pillar[5]arene derivative fused with a bipyridine side ring, so-called molecular universal joint (MUJ), was synthesized, and the pair of enantiomers resolved by high-performance liquid chromatography enantioresolution. The electrochemiluminescent detection based on ruthenium complex enantiopure MUJ showed excellent chiral discrimination toward certain amino acids.
Abstract A chiral electrochemically responsive molecular universal joint (EMUJ) was synthesized by fusing a macrocyclic pillar[6]arene (P[6]) to ferrocene‐based side ring. single crystal of an enantiopure EMUJ successfully obtained, which allowed, for the first time, definitive correlation between absolute configuration and circular dichroism spectrum P[6] derivative be determined. The self‐inclusion self‐exclusion conformational change led chiroptical inversion moiety, could manipulated...
The design and development of specific recognition sensing systems for biologically important anionic species has received growing attention in recent years, as they play significant roles biology, pharmacy, environmental sciences. Herein, a new supramolecular probe L1 was developed highly selective differentiation nucleotides. displayed extremely marked absorption emission upon binding with nucleotide homologs AMP, ADP, ATP, due to the divergent spatial orientations guests binding, which...
A novel pillar[5]arene-calix[4]pyrrole was synthesized as a chiral receptor for mandelate anions with maximum enantioselectivity of 2.47.
Butoxycarbonyl (Boc)-protected pillar[4]arene[1]-diaminobenzene (BP) was synthesized by introducing the Boc protection onto A1/A2 positions of BP. The oxygen-through-annulus rotation partially inhibited because presence middle-sized substituents. We succeeded in isolating enantiopure RP (RP, RP, and RP)- SP (SP, SP, SP)-BP, studied their circular dichroism (CD) spectral properties. As substituent is not large enough to completely prevent flip benzene units, BP-f1 underwent racemization...
A multihydroquinone ether dialdehyde derivative 2 was incidentally obtained through an unexpected ring opening of pillar[4]arene[1]quinone 1. And the Prato reaction with [60]fullerene led to bisadducts, from which trans-4 cyclic regioisomer 3 isolated and characterized. The fulleropillar[4]arene showed a larger cavity can accommodate viologen C12V2+ much stronger affinity than permethyl pillar[5]arene (MP5)
CO<sub>2</sub>- and photo-dual-responsive polymer vesicles with tunable wall thickness were explored used as a potential “smart” platform for drug release.
Nowadays, multidrug resistance is the main challenge during cancer chemotherapy. Photochemical internalization (PCI) has been demonstrated to be a unique and promising approach overcome with light-harnessed activation. Here, an amphiphilic pH-responsive block copolymer IR780 at junction point [PEG-IR780-PDEAEMA; PEG, poly(ethylene glycol); PDEAEMA, poly((diethylamino)ethyl methacrylate)] designed as perfect drug release platform well functional macromolecular photosensitizer of PCI....
Abstract Precisely controlling self‐assembly behavior and micro/nanostructure morphology of conjugated materials is significant for constructing optoelectronic devices. Inspired by natural functional materials, molecular stereoisomerism strategy (MSS) an effective convenient means to tune their arrangement macroscopic property materials. Herein, a supramolecular chiral difluorenols, 9,9′‐diphenyl‐9 H ,9′ ‐[2,2′‐bifluorene]‐9,9′‐diol (DPFOH), set as desirable model reveal the diastereomeric...
β-CDx derivatives invert the stereochemical outcome of syn -head-to-tail-photodimers, upon changing solution pH, solving problem antipodal-chiral hosts not being available.
Abstract Review: 49 refs.