A5071055628- Supramolecular Chemistry and Complexes
- Molecular Sensors and Ion Detection
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Molecular spectroscopy and chirality
- Crystallography and molecular interactions
- Photochromic and Fluorescence Chemistry
- Analytical Chemistry and Chromatography
- Porphyrin and Phthalocyanine Chemistry
- Luminescence and Fluorescent Materials
- Chemical Synthesis and Analysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Photoreceptor and optogenetics research
- Radical Photochemical Reactions
- Supramolecular Self-Assembly in Materials
- Synthesis and Properties of Aromatic Compounds
- Electrochemical Analysis and Applications
- Mass Spectrometry Techniques and Applications
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Plant-based Medicinal Research
- Surface Chemistry and Catalysis
- Electrocatalysts for Energy Conversion
- Photonic Crystals and Applications
- Lipid Membrane Structure and Behavior
Sichuan University
2014-2025
State Key Laboratory of Biotherapy
2014-2024
West China Hospital of Sichuan University
2019-2022
Chengdu University
2018-2020
Green Chemistry
2019
Stereoisomeric β-cyclodextrin (CD) dimers linked with a sulfur atom or an arene spacer were designed to create tethered dual CD capsule for precisely manipulating the regio- and enantioselectivities of photocyclodimerization 2-anthracenecarboxylate (AC) four stereoisomeric classical 9,10:9',10'-cyclodimers two nonclassical 5,8:9',10'-cyclodimers. Among dimeric hosts prepared, exo-3-thia-β-CD dimer formed 1:1 1:2 host-guest complexes AC in aqueous solutions, former which hindered but latter...
Complexation of achiral pillar[5]arenes with chiral amines induced strong circular dichroism (CD) signals. The CD responses differed drastically depending on the nature amino acid guest, and they significantly varied part them even inverted, upon increasing length alkyl chains guests. Accordingly, this tactic allowed for unprecedented simultaneous enantiomeric structural differentiation α-amino esters homologous molecular hosts.
Self-inhibition has been observed widely in hierarchical biochemical processes but yet to be demonstrated pure molecular physical rather than chemical or biological processes. Herein, we report an unprecedented example of self-inhibition during the supramolecular chirality induction, memory, erasure, and inversion pillar[5]arene (P[5]) derivatives. The addition chiral alanine ethyl ester bulky substituent-modified P[5]s led time-dependent induction due shift equilibrium SP RP conformers...
Abstract Amorphization and crystalline grain boundary engineering are adopted separately in improving the catalytic kinetics for water electrolysis. Yet, synergistic effect advance cooperated form of crystalline/amorphous interfaces (CAI) have rarely been elucidated insightfully. Herein, a trimetallic FeCo(NiS 2 ) 4 catalyst with numerous CAI (FeCo(NiS ‐C/A) is presented, which shows highly efficient activity toward both hydrogen oxygen evolution reactions (HER OER). Density functional...
Genetic manipulations and pharmaceutical interventions to disturb lipid metabolism homeostasis have emerged as an attractive approach for the management of cancer. However, research on utilization bioactive materials modulate remains constrained. In this study, heptakis (2,3,6-tri-O-methyl)-β-cyclodextrin (TMCD) is utilized fabricate homomultivalent polymeric nanotraps, surprisingly, its unprecedented ability perturb induce pyroptosis in tumor cells found. Through modulation density TMCD...
In the supramolecular photocyclodimerization of 2-anthracenecarboxylate mediated by 6A,6D-diguanidino-γ-cyclodextrin (CD), chiral sense and enantiomeric excess photoproduct were dynamic functions temperature cosolvent to afford (M)-anti head-to-head cyclodimer in 64% ee aqueous methanol at −70 °C but antipodal (P)-isomer 86% ammonia −85 °C, while corresponding diamino-γ-CD host did not show such unusual photochirogenic behaviors. The landscape was very steep against sign-inverted content...
Visible-light-driven enantiodifferentiating photodimerization of 2-anthracenecarboxylic acid (AC) sensitized by Schiff base Pt(II) complex-grafted γ-cyclodextrins leads the first triplet–triplet annihilation-based catalytic photochirogenesis. The syn-head-to-tail (HT) photodimer 2 was achieved in up to 31.4% ee at 61.0% conversion presence 0.5% equiv photocatalyst.
ConspectusStereochemical control of excited-state asymmetric photoreactions has been one the most challenging topics modern photochemistry. The short-lived character electronically excited photosubstrates and their low activation energy barriers to form both enantiomers are major obstacles achieving significant enantioselectivity in Recent research demonstrated that supramolecular strategy is promising stereochemical outcome photoreaction through relatively strong long-lasting noncovalent...
Mixing γ-cyclodextrin (γ-CD), cucurbit[6]uril (CB[6]) and tetraammonium-bearing axles together led to a spontaneous formation of γ-CD-CB[6]-cowheeled [4]pseudorotaxanes. The well-defined unsymmetrical cavities thus formed enhance the binding affinity towards chiral amines by factors several hundreds show remarkably improved discrimination.
The complexation of prism[5]arenes with amino acid derivatives showed association constants up to 107 M-1, significant CD gabs 0.8 × 10-2 and CPL glum 2 10-3. absolute configuration-CD signal correlation was established. spectra varied significantly the substituents on prism[5]arenes.
Tri-cavity hosts consisting of one pillar[5]arene (P5) sandwiched by two β-cyclodextrins (CDs) were synthesized, and their diastereoseparation was successfully accomplished. Photocyclodimerization 2-anthracenecarboxylate with these hybrid demonstrated the critical dependence stereoselectivity on absolute configuration central P5 conjugating positions β-CD, gave non-classical HT photodimers in up to 87% ee.
Singlet chiral photocatalysis is highly challenging. Herein, we report fluorescence resonance energy transfer (FRET)-based with γ-cyclodextrin (CD)-grafted lanthanide-doped upconverted nanoparticles (UCNP). The CD-modified UCNP strongly emits in the UV wavelength region upon excitation a 980 nm laser, which selectively sensitizes photosubstrates complexed by CD on surface of through FRET. Therefore, enantiodifferentiating photocyclodimerization anthracene or naphthalene derivatives...
The value of octa acid (OA) as a reaction vessel in steering photoreaction toward less favored product was established. Photodimerization 2-anthracenecarboxylic within OA yields exclusively head-to-head dimers, while media such solution, cyclodextrins (CD) and related hosts yield predominantly head-to-tail dimers. Further, enhances the chiral selectivity on difference between CD is attributed to variation dimensions their entry ports.
Several γ-cyclodextrin (γ-CDx) derivatives were used as chiral hosts for the photocyclodimerization of 2-anthracenecarboxylic acid (AC). The effect pH on photoreactivity and stereochemical outcome photoproducts was investigated. Upon changing solution pH, HH cyclodimer 3 inverted from 25.2% to −64.4% 41.2% −76.2%, respectively, in AC mediated by bis-quinoline-modified γ-CDx 7 its N-methylated derivative 8.
Pillar[4]arene[1]quinone derivatives (PQXs) were synthesized by the oxidation of pillar[5]arenes, which exhibited notable charge transfer (CT) transitions at approximately 485 nm. Successful chiral resolution two pairs enantiomeric conformers was achieved. Despite reduced binding affinity, PQXs demonstrated slower racemization kinetics. Visible-light chiroptical induction with a significant dissymmetry factor attained complexing guest. The induced excess could be maintained through...
Reaction of chiral amines with benzaldehydes 3,5-disubstituted by two pyrenes or perylenes afforded corresponding double winged imines, which aggregated to show significantly enhanced circular dichroism spectra at the transition bands chromophores in mixture solutions DMF and H2O.
The host component β-cyclodextrin (β-CD) and the guest tertiary-butyl (<italic>t</italic>-Bu) were introduced into polymeric backbone material of an inverse opal hydrogel.