A5052992884- Nanoplatforms for cancer theranostics
- Photopolymerization techniques and applications
- Collagen: Extraction and Characterization
- Dendrimers and Hyperbranched Polymers
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Nanoparticle-Based Drug Delivery
- Synthesis and properties of polymers
- Dyeing and Modifying Textile Fibers
- Polymer composites and self-healing
- Cancer Research and Treatments
- Advanced Computing and Algorithms
- Advanced Polymer Synthesis and Characterization
- Textile materials and evaluations
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Petroleum Processing and Analysis
- Drilling and Well Engineering
- Microplastics and Plastic Pollution
- Advanced battery technologies research
- Autophagy in Disease and Therapy
- Biological Activity of Diterpenoids and Biflavonoids
- Photodynamic Therapy Research Studies
Sichuan University
2021-2025
West China Hospital of Sichuan University
2021-2024
State Key Laboratory of Biotherapy
2021-2024
Sungkyunkwan University
2016-2020
Zhongda Hospital Southeast University
2017
Suwon Research Institute
2016
Government of the Republic of Korea
2016
East China University of Science and Technology
2015
Southeast University
2014
Shaanxi University of Science and Technology
2010-2013
To improve the response rate of immune checkpoint inhibitors such as anti-PD-L1 antibody in immunosuppressive cancers like triple-negative breast cancer (TNBC), induction immunogenic cell death (ICD) at tumor sites can increase antigenicity and adjuvanticity to activate microenvironment so that tumors become sensitive intervention inhibitors. Herein, a self-amplified biomimetic nanosystem, mEHGZ, was constructed by encapsulation epirubicin (EPI), glucose oxidase (Gox) hemin ZIF-8...
Despite the great potential of anti-PD-L1 antibodies for immunotherapy, their low response rate due to an immunosuppressive tumor microenvironment has hampered application. To address this issue, we constructed a cell membrane-coated nanosystem (mB4S) reverse immuno-supportive one strengthening anti-tumor effect. In system, Epirubicin (EPI) as immunogenic death (ICD) inducer was coupled branched glycopolymer
Exosomes play important roles in cell-cell communication, and are likely mediators of the metastatic cascade cancer. This study examined role exosomes pancreatic cancer cell adhesion, migration, invasion. We isolated purified from two isogenic lines with different potentials. Uptake highly Panc02-H7 cells decreased adhesion increased migration invasion capacity weakly Panc02 vitro. induced liver pre-metastatic niche formation naïve mice promoted primary tumor growth metastasis vivo....
Abstract Immune response in the tumor microenvironment (TME) is an essential therapeutic factor for antitumor therapy. Herein, to improve immunostimulatory effects, photodynamic therapy (PDT) combined with AZD2281 trigger stimulator of interferon genes (STING)‐dependent immune responses. A synthetic branched polymer‐pyropheophorbide a (Ppa) conjugate (BGSSP) designed and developed redox/cathepsin B TME. This unique structure large molecular weight (MW) can self‐assemble into compact via...
Abstract Amorphization and crystalline grain boundary engineering are adopted separately in improving the catalytic kinetics for water electrolysis. Yet, synergistic effect advance cooperated form of crystalline/amorphous interfaces (CAI) have rarely been elucidated insightfully. Herein, a trimetallic FeCo(NiS 2 ) 4 catalyst with numerous CAI (FeCo(NiS ‐C/A) is presented, which shows highly efficient activity toward both hydrogen oxygen evolution reactions (HER OER). Density functional...
Tumor cells are dominant in the nutritional competition tumor microenvironment, and their metabolic abnormalities often lead to microenvironmental acidosis nutrient deprivation, thereby impairing function of immune diminishing antitumor therapeutic effect. Herein, a branched polymeric conjugate its efficacy attenuating reported. Compared with control nanoparticles prepared from linear counterpart, branched-conjugate-based can more efficiently accumulate tissue interfere processes increase...
Strategically targeting lymph nodes (LNs) to orchestrate the initiation and regulation of adaptive immune responses is one most pressing challenges in context vaccination. Herein, a series polymer-TLR agonist conjugates (PTACs) developed investigate impact dendritic-topological characteristics on their LN activity vivo, molecular weight (MW) pharmacokinetics support homing. Notably, dendritic 6-arm PTAC with MW 60 kDa (6A-PTAC-60k) rapidly delivered cargo draining LNs after administration...
Abstract The presence of immunosuppressive cells such as tumor‐associated macrophages (TAMs) and myeloid‐derived suppressor (MDSCs) in residual tumors after surgery is known to be related high recurrence which are more resistant therapeutic interventions compared with the primary ones. Herein, a degradation‐regulatable architectured implantable macroporous scaffold (Dr‐AIMS) designed control tumor microenvironments (TMEs) well activate T‐cell‐based antitumor immunity. Dr‐AIMS fabricated by...
The aim of this work was to investigate the changes induced on nylon 6 fibers after moderate treated with formic acid and sulfuric acid. dyeing properties treatment reactive dye were measured. content amino groups, moisture absorption contact angle non-treated fabrics determined effects structure, thermo-stability morphology fibers investigated by FT-IR, SEM DSC. results indicate that hydrophilicity enhanced dyeability improved treatment.
The most used flocculants in treatment of waste drilling water are PAM flocculants. But its polymeric monomer often has toxicity. Gelatin is a non-toxic, amphipathic natural macromolecule. prepared by gelatin and application not been reported. In the experiment, was extracted from chrome shavings. Sulfate, citric acid trypsinase were chosen to hydrolyze then collagen solution obtain. Then NaNO 2 added seal amino molecules. flocculation effects before after sealing on fluid estimated CODcr...
In order to avoid using P2O5 as phosphorylation reagent in reaction, an amphoteric phosphate ester surfactant was synthesized by polyphosphate acid reagent. The reaction studies confirmed the best condition molar ratio of hydroxyl and 3.0:1.0, temperature 80°C time 5.5h. content monoalkyl (MAP) conversion rate reached 89.3% 97.2%, respectively. production MAP product increased 15% than that obtained structure characterized FTIR. surface tension better dodecyl trimethyl ammonium bromide...
Hypoxia-responsive chitosan nanoparticles synthesized by the conjugation of nitro-benzyl derivatives into polymers and subsequent self-assembly them with hydrophobic fluorophores, were successfully applied for rapid determination hypoxic status lung carcinoma cells (A549) within 30 min.
A novel hyperbranched polyurethane (HBPU) finishing agent was prepared by graft copolymerization of poly (amine-ester) polyols (HPAE) and the isocyanate-terminated prepolymer(PPU). The PPU synthesized step polymerization isophorone diisocyanate (IPDI) with polyethylene glycol (PEG) dibutyltin dilaurate (DBTDL) as catalyst. FT-IR spectroscopy used for structural characterization. thermal properties HBPU were characterized TGA. Microphase separation film surface studied tapping-mode atomic...
A color fixing agent of collagen (PCDMC) was prepared by free radical polymerization water solution methacryloyloxy ethyl trimethyl ammonium chloride (DMC) with hydrolysate at the protection nitrogen and using t-butylhydroperoxide (t-BHP) sodium metabisulfite (SMBS) as redox initiator pair. The solid content viscosity 37% 300-600mPa•s, respectively. Then it used in leather process compared commercial products DT-A622 formic acid. handle, dye uptake rate, K/S value resistance to dry wet...
The silicone succinate ester surfactant (PMPS) was synthesized by the raw materials of polyether alcohol amine modified polysilosane (PAPS) and maleic anhydride (MA) at 90°C for 4.5h, p-toluenesulfonic acid (PTSA) used as catalyst. Sulfated neatsfoot oil, oxidized-sulfited fish oil mixed with PMPS to prepare a new leather fatliqour (F-1). structure were characterized FTIR. biodegradability F-1 analyzed BOD 5 COD Cr tissue slices samples oiled observed Multimedia Microscope study fatliquoring...
The silicone succinate surfactant (PMPS) was synthesized by ring-opening reaction using polyether alcohol amine modified polysilosane (PAPS) with maleic anhydride (MA) as the raw materials, and p-toluenesulfonic acid (PTSA) used catalyst. Sulfated castor oil sulfated rapeseed were combinated PMPS to prepare a new leather fatliqour (PMPSF) composed mainly of PMPS. molecular structure characterized FTIR spectra; thermal properties analyzed TGA. PMPSF in sheepskin wet blue compared oxidative...
The methods of BOD5/CODCr, respiratory curve and COD30 were adopted to evaluate the biodegradability oxidized sulfiting rapeseed oil fatliquor. results showed that when concentrations substrate 250 mg/L 500mg/L dosage unacclimated activated sludge was 300mg pH 7, biodegradable biodegradation rate up 90%. When with concentration 1000mg/L became bad reduced 80.9%. Moreover, effect pH, inoculation amount salinity on obvious. best as 7 alkaline medium had little influence substrate. increased...
Different types of formaldehyde scavenger were used to remove free in aldehyde tanning leather. The results showed that: the removal effect self-made aminated collagen (EAC) was best, followed by hyperbranched polymer with active methylene (HPAM). Then mixture EAC and HPAM formaldehyde. optimum conditions obtained single factor experiment. weight ratio 1:1 processing time 2h. Finally, EAC, chitosan oxazolidine tanned sheep skin. comparison that formaldehyde-removal rate reached 75% which...