A5021758819- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Hematopoietic Stem Cell Transplantation
- Immune Response and Inflammation
- CAR-T cell therapy research
- Erythropoietin and Anemia Treatment
- Cytokine Signaling Pathways and Interactions
- Pharmacological Effects of Natural Compounds
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Heat shock proteins research
- Ginseng Biological Effects and Applications
- Redox biology and oxidative stress
- NF-κB Signaling Pathways
- Kruppel-like factors research
- Acute Myeloid Leukemia Research
- Adipokines, Inflammation, and Metabolic Diseases
- Protein Kinase Regulation and GTPase Signaling
- Mesenchymal stem cell research
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- interferon and immune responses
- Endoplasmic Reticulum Stress and Disease
- Cellular Mechanics and Interactions
Korea Research Institute of Bioscience and Biotechnology
2016-2025
Korea University of Science and Technology
2014-2025
Sookmyung Women's University
2017
Chonnam National University
2014
Korea Food Research Institute
2011
Jeonbuk National University
2011
Chungnam National University
2008
Université de Montréal
2003-2006
STUDY QUESTIONIs the decreased natural killer (NK) cell cytolytic activity in peritoneal fluid (PF) of endometriosis patients due to primary cytokine activity?
Natural killer (NK) cells play important roles in immune surveillance. However, the tumor microenvironment suppresses NK cell function and allows cancer to evade detection. In this study, we investigated whether thyroid has effect on cells. We found that prostaglandin (PG) E2 produced by suppressed cytolytic activity of inhibiting expression natural cytotoxicity receptors NKp44 NKp30 death receptor necrosis factor-related apoptosis-inducing ligand. PGE2 cyclooxygenase-2 were highly expressed...
The doses of donor-derived natural killer (NK) cells that can be given safely after human leukocyte antigen (HLA)-haploidentical hematopoietic cell transplantation (HCT) remain to defined. Forty-one patients (ages 17 75 years) with hematologic malignancy underwent HLA-haploidentical HCT reduced-intensity conditioning containing busulfan, fludarabine, and antithymocyte globulin. Cell donors 7 62 growth factor-mobilized leukapheresis for 3 4 days. Cells collected on the first 2 days were used...
Abstract NK cells are a key component of innate immune systems, and their activity is regulated by cytokines hormones. Adiponectin, which secreted from white adipose tissues, plays important roles in various diseases, including hypertension, cardiovascular inflammatory disorders, cancer. In this study the effect adiponectin on cell was investigated. Adiponectin found to suppress IL-2-enhanced cytotoxic without affecting basal cytotoxicity inhibit IL-2-induced NF-κB activation via...
Ageing is a natural process in living organisms throughout their lifetime, and most elderly people suffer from ageing-associated diseases. One suggested way to tackle such diseases rejuvenate stem cells, which also undergo ageing. Here we report that the thioredoxin-interacting protein (TXNIP)-p38 mitogen-activated kinase (p38) axis regulates ageing of haematopoietic cells (HSCs), by causing higher frequency long-term HSCs, lineage skewing, decrease engraftment, an increase reactive oxygen...
The nuclear factor kappa B (NF-κB) pathway is pivotal in controlling survival and apoptosis of cancer cells. Macrophage migration inhibitory (MIF), a cytokine that regulates the immune response tumorigenesis under inflammatory conditions, upregulated various tumors. However, intracellular functions MIF are unclear. In this study, we found directly interacted with thioredoxin-interacting protein (TXNIP), tumor suppressor known inhibitor NF-κB activity, significantly induced activation....
Although N-myc downstream regulated gene 2 (NDRG2) has been known to be a tumor suppressor gene, the function of this not elucidated. In present study, we investigated expression and NDRG2 in human gastric cancer. Among seven cancer two non-cancer cell lines, only SNU-16 SNU-620, expressed NDRG2, which was detected cytoplasm. Interestingly, highly normal tissues, but patients were divided into NDRG2-positive -negative groups. The survival rate NDRG2-negative lower than that patients. We...
Cancer therapy often produces anemia, which is treated with erthropoietin (EPO) to stimulate erythrocyte production. However, concerns have recently arisen that EPO treatment may promote later tumor metastasis and mortality. The mechanisms underlying such effects are unknown, but it clear has pleiotropic in cell types other than hematopoietic cells. In this study, we investigated how affects lymphangiogenesis lymph node mouse models of breast cancer melanoma. these models, increased a manner...
Thioredoxin-interacting protein (TXNIP) has multiple functions, including tumor suppression and involvement in cell proliferation apoptosis. However, its role the inflammatory process remains unclear. In this report, we demonstrate that Txnip−/− mice are significantly more susceptible to lipopolysaccharide (LPS)-induced endotoxic shock. response LPS, macrophages produced higher levels of nitric oxide (NO) inducible synthase (iNOS), an iNOS inhibitor rescued from shock-induced death,...
Abstract Cystatin SN (CST1) is a specific inhibitor belonging to the cystatin superfamily that controls proteolytic activities of cysteine proteases such as cathepsins. Our previous study showed high CST1 expression enhances tumor metastasis and invasiveness in colorectal cancer. Recently, auranofin (AF), gold(I)-containing thioredoxin reductase 1 (TrxR1) inhibitor, has been used clinically treat rheumatoid arthritis. AF proteasome-associated deubiquitinase can act an anti-tumor agent. In...
Natural killer (NK) cells are key players in the immune system. They use receptors on their cell surface to identify target cells. However, escape being killed by system, cancer such as thyroid cells, various methods suppress function of NK Thus, this study aims elucidate how downregulate a co-culture We found that cytotoxicity and inhibit expression activating receptors, NKG2D NKp46, regulating indoleamine 2,3-dioxygenase (IDO). Also, produce kynurenine using IDO, which causes dysfunction....
Ginseng is one of the most widely used herbal remedies for various diseases worldwide. Ginsenoside Rg3 (G-Rg3), main component ginseng, possesses several pharmacological properties, including anti-inflammatory, anti-tumor, antioxidant, anti-obesity, and immunomodulatory activities. However, effect G-Rg3 on natural killer (NK) cells in humans not fully understood. Here, we investigated NK cell function differentiation elucidated underlying mechanism. increased cytotoxicity simultaneously...