A5100672912- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Alzheimer's disease research and treatments
- Peptidase Inhibition and Analysis
- Occupational and environmental lung diseases
- Reproductive System and Pregnancy
- Medical Imaging and Pathology Studies
- T-cell and B-cell Immunology
- Endoplasmic Reticulum Stress and Disease
- Diagnosis and treatment of tuberculosis
- Neurogenesis and neuroplasticity mechanisms
- Tuberculosis Research and Epidemiology
- MRI in cancer diagnosis
- Immune Response and Inflammation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Conditions and Treatments
- Natural product bioactivities and synthesis
- Tissue Engineering and Regenerative Medicine
- Retinoids in leukemia and cellular processes
- Amoebic Infections and Treatments
- Liver Disease Diagnosis and Treatment
- Sarcoidosis and Beryllium Toxicity Research
- Vascular Tumors and Angiosarcomas
- Cardiovascular Function and Risk Factors
- Nuclear Receptors and Signaling
University of Ulsan
2006-2025
GenVec
2022-2023
Korea University
2023
Korea Brain Research Institute
2022
Yonsei University
2020-2021
Korea Basic Science Institute
2020
Korea Institute of Science and Technology
2018
Korea Research Institute of Bioscience and Biotechnology
2010-2017
Korea University of Science and Technology
2012-2017
Keimyung University
2009-2015
The formation and maintenance of granulomas is central to the host response Mycobacterium tuberculosis (Mtb) infection. It widely accepted that lungs patients with (TB) usually contain multiple infection foci, evolve differentiate independently, resulting in considerable heterogeneity. Although gene expression profiles human blood cells have been proposed as biomarkers Mtb and/or active disease, immune discrete lesion types has not studied extensively. Using histology, immunopathology...
The nuclear factor kappa B (NF-κB) pathway is pivotal in controlling survival and apoptosis of cancer cells. Macrophage migration inhibitory (MIF), a cytokine that regulates the immune response tumorigenesis under inflammatory conditions, upregulated various tumors. However, intracellular functions MIF are unclear. In this study, we found directly interacted with thioredoxin-interacting protein (TXNIP), tumor suppressor known inhibitor NF-κB activity, significantly induced activation....
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder, which characterized by cognitive deficit due to synaptic loss and neuronal death. Extracellular amyloid β plaques are one of the pathological hallmarks AD. The autophagic lysosomal pathway essential mechanism maintain cellular homeostasis driving clearance protein aggregates dysfunctional in Here, we showed that inhibiting MEK/ERK signaling using clinically available MEK1/2 inhibitor, trametinib (GSK1120212, SNR1611),...
The purpose of this study was to retrospectively assess whether measurement quantitative enhancement during three-phase MDCT can help differentiate clear cell renal carcinoma (RCC) from papillary RCC, chromophobe and fat-poor angiomyolipoma.During preoperative (unenhanced, corticomedullary, early excretory phases), 563 lesions were identified in 552 consecutively registered patients. assessed for attenuation each phase, the values compared by t test. Cutoff analysis (percentage ratio,...
To retrospectively determine diagnostic performance with multiparametric magnetic resonance (MR) imaging for detection of cancer different tumor volumes and Gleason grades in patients clinically low-risk prostate cancer.The local ethical committee institutional review board approved this study. Consecutive determined (n = 100) were examined MR (T2 weighted, diffusion dynamic contrast material enhanced) by using a 3.0-T imager before prostatectomy. Two radiologists independently assessed the...
Abstract Suppressor of cytokine signaling (SOCS) proteins are negative regulators responses. Although recent reports have shown regulatory roles for SOCS in innate and adaptive immunity, their natural killer (NK) cell development largely unknown. Here, we show that SOCS2 is involved NK development. −/− mice showed a high frequency cells the bone marrow spleen. Knockdown was associated with enhanced differentiation vitro , transplantation hematopoietic stem (HSCs) into congenic resulted HSCs....
ABSTRACT Trehalose 6,6′-dimycolate (TDM) is a cell wall glycolipid and an important virulence factor of mycobacteria. In order to study the role TDM in innate immune response Mycobacterium tuberculosis , microarray analysis was used examine gene regulation murine bone marrow-derived macrophages 90-μm-diameter polystyrene microspheres coated with TDM. A large number genes, particularly those involved macrophage function, were up- or downregulated these TDM-coated beads compared control beads....
Abstract Idiopathic pulmonary fibrosis (IPF) causes progressive and worsening function. Prognosis is poor no effective therapies exist. We show that programmed cell death 5 (PDCD5) expression increased in the lungs of patients with IPF mouse models lung fibrosis. Lung significantly diminished by club cell-specific deletion Pdcd5 gene. PDCD5 mediates β-catenin/Smad3 complex formation, promoting TGF-β-induced transcriptional activation matricellular genes. Club knockdown reduces protein...
Objectives. CXCL13 is a potent chemokine, produced by mature and recently recruited macrophages to sites of inflammation, which has antimicrobial anti-angiogenic properties. The purpose this study was to: (1) determine whether present in maternal serum, umbilical cord blood, amniotic fluid (AF); (2) if AF concentration changes with intra-amniotic infection/inflammation (IAI); (3) localize the production chorioamniotic membranes cord.Study design. A cross-sectional on serum performed...
Dietary fructose can rapidly cause fatty liver in animals through de novo lipogenesis (DNL) and contribute to the development severity of nonalcoholic disease (NAFLD). In response diverse cellular insults including endoplasmic reticulum (ER) oxidative stress, phosphorylation eukaryotic translation initiation factor 2 alpha subunit (eIF2α) attenuates general initiation, allowing cells conserve resources initiate adaptive gene expression restore homeostasis. The present study aimed investigate...
Idiopathic pulmonary fibrosis (IPF) is a serious lung disease characterized by excessive collagen matrix deposition and extracellular remodeling. Signaling pathways mediated fibrotic cytokine transforming growth factor β1 (TGF-β1) make important contributions to fibrosis, but it remains unclear how TGF-β1 alters metabolism modulates the activation differentiation of fibroblasts. We found that lowers NADH NADH/NAD levels, possibly due changes in TCA cycle, resulting reductions ATP level...
eIF2α phosphorylation helps maintain cellular homeostasis and overcome endoplasmic reticulum (ER) stress through transcriptional translational reprogramming. This study aims to elucidate the regulation of glutathione (GSH) NADPH its impact on cell death during ER stress. phosphorylation-deficient (A/A) cells exhibited decreased expression multiple genes involved in GSH synthesis production, leading an exacerbated depletion both mitochondrial GSH, as well NADPH, Impaired resulted from...
The function of natural killer (NK) cell-derived interferon-γ (IFN-γ) expands to remove pathogens by increasing the ability innate immune cells. Here, we identified critical role thioredoxin-interacting protein (TXNIP) in production IFN-γ NK cells during bacterial infection. TXNIP inhibited and activation transforming growth factor β-activated kinase 1 (TAK1) activity primary mouse human directly interacted with TAK1 interfering complex formation between binding (TAB1). Txnip−/− (KO)...
The aspects of cellular metabolism controlled by phosphatidylinositol phosphates (PtdInsPs) have been broadly expanded, and these phospholipids drawn tremendous attention as pleiotropic signaling molecules. PtdInsPs analysis using LC/MS/MS has remained challenging due to the strong hydrophilicity lipids. Multiple reaction monitoring (MRM) or a neutral loss scan performed quantitatively measure after chemical derivatization on phosphate groups inositol moieties. Only predefined can be...
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with poor prognosis similar to that of malignancy. The causes IPF are not clearly known, and there no effective therapy date. In this study, the natural compound plumbagin, which was isolated from Plumbago rosea root extract, screened for p300 inhibitory activity. Plumbagin specifically inhibited activity toward histone acetyltransferases. treatment significantly suppressed transforming growth...
Liver fibrosis is caused by chronic liver damage and results in the aberrant accumulation of extracellular matrix during disease progression. Despite identification HAT enzyme p300 as a major factor for fibrosis, development therapeutic agents targeting regulation has not been reported. We validated novel inhibitor (A6) on improvement using two mouse models, mice choline-deficient high-fat diet thioacetamide-treated mice. demonstrated that pathological hall-marks were significantly...
Abstract Gastric cancer (GC) patients usually receive surgical treatment. Postoperative therapeutic options such as anticancer adjuvant therapies (AT) based on prognostic prediction models would provide patient-specific treatment to decrease postsurgical morbidity and mortality rates. Relevant factors in resected GC patient’s serum may improve measures a non-invasive manner. In order develop model, we designed retrospective study. this study, samples were collected from 227 at 4-week...
Reactive oxygen species (ROS) play a significant role in intracellular signaling and regulation, particularly when they are maintained at physiologic levels. However, excess ROS can cause cell damage induce death. We recently reported that eIF2α phosphorylation protects hepatocytes from oxidative stress liver fibrosis induced by fructose metabolism. Here, we found hepatocyte-specific phosphorylation-deficient mice have significantly reduced expression of the epidermal growth factor receptor...
Enhancing adult neurogenesis in the brain has been suggested as a potential therapeutic strategy for AD. We developed screening platform, ATRIVIEW®, molecules that activate neuronal differentiation of mouse NSCs. The most potent hit from an FDA-approved drug library was SNR1611 (trametinib), selective MEK1/2 inhibitor. found trametinib increases levels P15INK4b and Neurog2, suggesting mechanism by which inhibition induces differentiation. Oral administration increased dentate gyrus...
Idiopathic pulmonary fibrosis (IPF) is a lung disease that results in scarring of the lungs for an unknown reason. Although many studies have been conducted on IPF, precise mechanisms and treatments not yet identified. In this study, we found aucuparin, natural product isolated from Sorbus aucuparia, inhibited bleomycin (BLM)-induced mouse model. samples mice treated with gene expression inflammation macrophage activation markers was reduced compared to those BLM alone. Moreover, aucuparin...