A5015752428- Nanoplatforms for cancer theranostics
- Solid-state spectroscopy and crystallography
- Nanoparticle-Based Drug Delivery
- Lanthanide and Transition Metal Complexes
- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- Quantum Dots Synthesis And Properties
- RNA Interference and Gene Delivery
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- NMR spectroscopy and applications
- Immunotherapy and Immune Responses
- Luminescence and Fluorescent Materials
- Mesenchymal stem cell research
- Neurogenesis and neuroplasticity mechanisms
- Glass properties and applications
- Nanocluster Synthesis and Applications
- Electron Spin Resonance Studies
- Immune Cell Function and Interaction
- Viral Infections and Immunology Research
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neuropharmacology Research
- Characterization and Applications of Magnetic Nanoparticles
- Magnetism in coordination complexes
- Extracellular vesicles in disease
Korea Basic Science Institute
2015-2024
Chungnam National University
2013-2024
Chung-Ang University
2008-2024
Cheongju University
2016-2020
Korea Research Institute of Bioscience and Biotechnology
2009-2018
Korea University of Science and Technology
2011-2016
Korea University
1998-2014
The University of Texas at Austin
2014
Harvard University Press
2013
Catholic University of Korea
1989-2012
Metastatic cancers have historically been difficult to treat. However, metastatic tumors found high levels of reactive oxygen species such as hydrogen peroxide (H2O2), supporting the hypothesis that a prodrug could be activated by intracellular H2O2 and lead potential antimetastatic therapy. In this study, 7 was designed H2O2-mediated boronate oxidation, resulting in activation fluorophore for detection release therapeutic agent, SN-38. Drug from investigated monitoring fluorescence after...
Abstract A new theranostic strategy is described. It based on the use of an “all in one” prodrug, namely biotinylated piperazine‐rhodol conjugate 4 a . This conjugate, which incorporates anticancer drug SN‐38, undergoes self‐immolative cleavage when exposed to biological thiols. leads tumor‐targeted release active SN‐38 payload along with fluorophore 1 made selective as result biotin functionality. Fluorophore 32‐fold more fluorescent than prodrug permits delivery and be monitored easily...
A series of heptamethine cyanine (1–3) derivatives bearing a carbamate ethyl disulfide group and gemcitabine, an anticancer drug, have been newly synthesized. Their bonds are readily cleaved by various thiols including glutathione, to result in subsequent decomposition the into amine followed release active which can be monitored fluorescence changes. In biological experiment, prodrug 1 is preferentially up-taken folate-positive KB cells over folate-negative A549 via receptor-mediated...
The low response rate of current cancer immunotherapy suggests the presence few antigen-specific T cells and a high number immunosuppressive factors in tumor microenvironment (TME). Here, we develop syringeable immunomodulatory multidomain nanogel (iGel) that overcomes limitation by reprogramming pro-tumoral TME to antitumoral immune niches. Local extended release drugs from iGel deplete cells, while inducing immunogenic cell death increased immunogenicity. When is applied as local...
Reported here is a new theranostic agent, 1, which consists of Gd3+-texaphyrin core conjugated to doxorubicin prodrug via disulfide bond. Conjugate 1 was designed undergo cleavage in the presence glutathione (GSH), species typically upregulated cancer cells. As prepared, conjugate displays no appreciable fluorescence. However, when exposed excess GSH an increase fluorescence intensity at 592 nm observed that ascribed release free doxorubicin. To improve solubility and enhance tumor targeting...
Protein-based Cas9 in vivo gene editing therapeutics have practical limitations owing to their instability and low efficacy. To overcome these obstacles improve stability, we designed a nanocarrier primarily consisting of lecithin that can efficiently target liver disease encapsulate complexes with single-stranded guide RNA (sgRNA) ribonucleoprotein (Cas9-RNP) through polymer fusion self-assembly. In this study, optimized an sgRNA sequence specifically for dipeptidyl peptidase-4 (DPP-4)...
Tumor hypoxia is correlated with increased resistance to chemotherapy and poor overall prognoses across a number of cancer types. We present here cell-selective hypoxia-responsive probe (fol-BODIPY) designed on the basis density functional theory (DFT)-optimized quantum chemical calculations. The fol-BODIPY was found provide rapid fluorescence "off–on" response relative controls, which lack folate or nitro-benzyl moieties. In vitro confocal microscopy flow cytometry analyses, as well in vivo...
Ischemic stroke mainly caused by middle cerebral artery occlusion (MCAo) is a major type of stroke, but there are currently very limited therapeutic options for its cure. Neural stem cells (NSCs) or neural precursor (NPCs) derived from various sources known to survive and improve neurological functions when they engrafted in animal models stroke. Induced pluripotent (iPSCs) generated somatic patients novel that promise the autologous cell therapy In this study, we successfully differentiated...
Described here is the development of gadolinium(III) texaphyrin-platinum(IV) conjugates capable overcoming platinum resistance by 1) localizing to solid tumors, 2) promoting enhanced cancer cell uptake, and 3) reactivating p53 in platinum-resistant models. Side side comparative studies these Pt(IV) clinically approved platinum(II) agents previously reported platinum(II)-texaphyrin demonstrate that present are more stable against hydrolysis nucleophilic attack. Moreover, they display high...
The chemodosimetric behavior of dichlorofluorescein derivatives toward Hg2+ ions was investigated. Simple systems showed selective and efficient signaling behaviors micromolar concentrations over other common interfering metal in an aqueous environment. mechanism is mercuration the 4′,5′-position xanthene moiety, which results chromogenic fluorogenic
To understand the fates of human mesenchymal stem cells (hMSCs) following transplantation into a rodent model middle cerebral artery occlusion (MCAo), magnetic resonance imaging (MRI) techniques were employed, hMSCs labeled with ferumoxides (Feridex)--protamine sulfate complexes, which visualized and examined by MRI up to 10 weeks transplantation. Migration transplanted infarcted area was further confirmed histological methods. We found that in MCAo models possess capacity migrate...
Here, we describe an easy but robust chemical strategy to synthesize high-performance magnetic resonance (MR)/near-infrared (NIR) multimodal imaging nanoprobes. Poly(γ-glutamic acid) was used for the convenient phase transfer of MnFe2O4 nanoparticles dispersed in organic solvents into aqueous solutions and facilitated further ionic gelation with poly(l-lysine). During process, nanoparticulate satellites were encapsulated nanocomplex, which induced synergistic magnetism resulted huge T2...
Subanesthetic doses of ketamine, a noncompetitive N ‐methyl‐ D ‐aspartate (NMDA) receptor antagonist, impair prefrontal cortex (PFC) function in the rat and produce symptoms humans similar to those observed patients with schizophrenia. In present study, vivo 1 H‐MRS ex H high‐resolution magic angle spinning (HR‐MAS) spectroscopy was used examine brain metabolism rats treated subanesthetic ketamine (30 mg/kg) for 6 days. A single voxel localization sequence (PRESS, TR/TE = 4000/20 ms NEX 512)...
A water-soluble T1 magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal 1 responds to the Cu2+ ion in living cells by enhancing MRI modality signal whereas optical gradually drops. This dual probe response depends on cellular free copper ions RAW 264.7 even at micromolar level.
Abstract: Injectable and stimuli-responsive hydrogels have attracted attention in molecular imaging drug delivery because encapsulated diagnostic or therapeutic components the hydrogel can be used to image change microenvironment of injection site by controlling various stimuli such as enzymes, temperature, pH, photonic energy. In this study, we developed a novel injectable photoresponsive composite composed anticancer drugs, contrast agents, bio-derived collagen, multifaceted anionic...
Here, we describe the fabrication of multispectrally encoded nanoprobes, perfluorocarbon (PFC)/quantum dots (QDs) nanocomposite emulsions, which could provide both multispectral MR and multicolor optical imaging modalities. Our strategy exploited combination properties four different PFC materials emission three colored CdSe/ZnS QDs. The PFC/QDs emulsions were fabricated by exchanging hydrophobic ligands coated onto QDs using 1H,1H,2H,2H-perfluorooctanethiol, renders to be dispersible in...
Neonatal asphyxia is an important contributor to cerebral palsy (CP), for which there no effective treatment date. The administration of human cord blood cells (hUCBCs) emerging as a therapeutic strategy the neurological disorders. However, are few studies on application hUCBCs neonatal ischemia model CP. Experiments and behavioral tests (mainly motor tests) performed hypoxia/ischemia have been limited short-term effects hUCBCs, but mechanisms action not investigated. We study use in rat...
Ischemic stroke mainly caused by middle cerebral artery occlusion (MCAo) represents the major type of stroke; however, there are still very limited therapeutic options for stroke-damaged patients. In this study, we evaluated neurogenic and potentials human neural stem cells (NSCs) overexpressing brain-derived neurotrophic factor (HB1.F3.BDNF) following transplantation into a rodent model MCAo. F3.BDNF NSCs (F3.BDNF) were transplanted contralateral side striatum at 7 days after MCAo, animals...
Background— Limited availability of noninvasive and biologically precise diagnostic tools poses a challenge for the evaluation management patients with myocarditis. Methods Results— The feasibility cardiovascular magnetic resonance (CMR) imaging magneto-fluorescent nanoparticles (MNPs) detection myocarditis its effectiveness in discriminating inflammation grades were assessed experimental autoimmune (EAM) (n=65) control (n=10) rats. After undergoing CMR, rats administered MNPs, followed by...
A self-assembled amphiphilic fluorescent probe allows pH-fluctuations within cancer cells and tumour tissues to be readily detected.