A5037312138- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Lanthanide and Transition Metal Complexes
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- RNA Interference and Gene Delivery
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Advanced Nanomaterials in Catalysis
- Magnetic and transport properties of perovskites and related materials
- Photodynamic Therapy Research Studies
- Graphene and Nanomaterials Applications
- ZnO doping and properties
- Graphene research and applications
- Soil Moisture and Remote Sensing
- MRI in cancer diagnosis
- Integrated Circuits and Semiconductor Failure Analysis
- Hydrogen Storage and Materials
- Bipolar Disorder and Treatment
- Advancements in Photolithography Techniques
- Schizophrenia research and treatment
- Epilepsy research and treatment
- Hepatitis B Virus Studies
Sichuan University
2016-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2019-2025
Fudan University
2019-2025
Zhejiang Chinese Medical University
2025
West China Hospital of Sichuan University
2016-2025
Shanghai Institute for Science of Science
2025
Gannan Medical University
2025
Hebei North University
2019-2024
Shanghai Jiao Tong University
2014-2024
State Key Laboratory of Biotherapy
2021-2023
A pathology-adaptive nanosystem, in which nest-like hosts are built based on nanofibers that transformed from i.v. injected nanoparticles under the acidic tumor microenvironment. The solid is artificially modified by readily and firmly, resulting highly efficient accumulation stabilization of guest theranostics. This strategy shows great potential for theranostics delivery to tumors.
Owing to their dendritic architectural features, branched copolymers have been investigated as drug delivery systems. In this paper, an enzyme- and pH-sensitive poly[N-(2-hydroxypropyl)methacrylamide] (polyHPMA) copolymer–doxorubicin (DOX) conjugate possessing a molecular weight (MW) of 165 kDa was designed prepared via one-pot reaction conjugation. This conjugate's potential smart, nanoscale system (NDDS) is also investigated. The capable forming nanoparticles with negative surface charge....
Multi-modal therapeutics are emerging for simultaneous diagnosis and treatment of cancer. Polymeric carriers often employed loading multiple drugs due to their versatility controlled release these in response a tumor specific microenvironment. A theranostic nanomedicine was designed prepared by complexing small gadolinium chelate, conjugating chemotherapeutic drug PTX through cathepsin B-responsive linker covalently bonding fluorescent probe pheophorbide (Ppa) with branched glycopolymer. The...
Abstract Immune response in the tumor microenvironment (TME) is an essential therapeutic factor for antitumor therapy. Herein, to improve immunostimulatory effects, photodynamic therapy (PDT) combined with AZD2281 trigger stimulator of interferon genes (STING)‐dependent immune responses. A synthetic branched polymer‐pyropheophorbide a (Ppa) conjugate (BGSSP) designed and developed redox/cathepsin B TME. This unique structure large molecular weight (MW) can self‐assemble into compact via...
Nanoprobes that offer both fluorescence imaging (FI) and magnetic resonance (MRI) can provide supplementary information hold synergistic advantages. However, synthesis of such dual-modality probes simultaneously exhibit tunability functional groups, high stability, great biocompatibility desired results remains challenging. In this study, we used an amphiphilic block polymer from (ethylene glycol) methyl ether methacrylate (OEGMA) N-(2-hydroxypropyl) methacrylamide (HPMA) derivatives as a...
Inspired by natural saccharide-protein complexes, a stimuli-responsive biodegradable and branched glycopolymer-pyropheophorbide-a (Ppa) conjugate (BSP) with saccharide units for cancer therapy is constructed. A linear glycopolymeric (LSP), (BShP) from Ppa long carbon chains, (BHSP) based on poly[N-(2-hydroxypropyl) methacrylamide] (polyHPMA) without are prepared as controls. Through structure-activity relationship studies, BSP 3D network structure forms stable nanostructures via weak...
Efficient penetration and retention of therapeutic agents in tumor tissues can be realized through rational design drug delivery systems. Herein, a polymer-dendron conjugate, POEGMA-b-p(GFLG-Dendron-Ppa) (GFLG-DP), is presented, which allows cathepsin-B-triggered stealthy-to-sticky structural transformation. The compositions ratios are optimized dissipative particle dynamics simulations. GFLG-DP displays tumor-specific transformation the consequently released dendron-Ppa found to effectively...
Atherosclerosis is a significant contributor to global cardiovascular disease. Reducing the formation of atherosclerotic plaque effectively can lead decrease in diseases. Therefore, controlling macrophage function crucial. This study presents creation bifunctional nanoparticle that specific macrophages achieve intracellular and extracellular synergistic therapy for restoring functions. The conjugated with anti-CD47 antibody modulate CD47-SIRPα phagocytic signaling axis on outer surface...
Au-BP7@SP nanohybrids with active motion under NIR laser irradiation can effectively enhance the temperature of tumor potentially by converting kinetic energy to thermal energy, enhancing killing efficiency cells compared Au@SP. The study provides an insight nanohybrids' effect on photothermal treatment and opens a new avenue cancer using self-propulsion Janus nanohybrids. As service our authors readers, this journal supporting information supplied authors. Such materials are peer reviewed...
Owing to the low efficacy of clinically used small-molecule gadolinium (Gd)-based magnetic resonance imaging (MRI) agents, we designed and explored biodegradable macromolecular conjugates as MRI contrast agents. The linear polymeric structure core-cross-linked formulation possessed different characteristics features, so prepared comparatively studied two kinds Gd-based N-(2-hydroxypropyl) methacrylamide (HPMA) systems (the pHPMA-DOTA-Gd one) using clinical agent diethylene-triamine...
A ROX and enzyme-responsive biodegradable gadolinium-based mCA was prepared, demonstrating a short gadolinium retention time sufficient MRI contrast efficacy in tumors.
The efficacy and biocompatibility of nanoscale magnetic resonance imaging (MRI) contrast agents depend on optimal molecular structures compositions. Gadolinium [Gd(III)] based dendritic macromolecules with well-defined tunable sizes are excellent candidates as multivalent MRI agents. Here, we propose a novel alternate preparation biodegradable hyperbranched polymer–gadolinium conjugates via simple strategy report potentially efficient biocompatible for cancer diagnosis. enzyme-responsive...
Nano-theranostic agents play important roles in the development of therapeutic methods for serious diseases. In this study, novel carbon dots (CDs) L-CD/C-CD were prepared from Gd(iii) salt/complexes, cationic polymers and citric acid hope that they would combine abilities gene delivery multi-modal (MR/FL) imaging. The CDs inherited properties good water-solubility positive charge their precursor polymers. vitro transfection results showed have efficiency anti-serum ability, especially L-CD,...
Click and analyze: The titled probe was synthesized by conjugating a sulfonyl fluoride azido unit using click chemistry to give SF-Eu, which can react specifically with serine (Ser) in the active site of protease (SP). Combination method 153Eu-isotope dilution ICP/MS enables absolute protein quantification SPs biological samples only one 153Eu(NO3)3 isotopic standard. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not...
We report an assembly and transformation process of a supramolecular module, BP-KLVFF-RGD (BKR) in solution on specific living cell surfaces for imaging treatment. The BKR self-assembled into nanoparticles, which further transformed nanofibers situ induced by coordination with Ca2+ ions.
For atomically thin two-dimensional materials, interfacial effects may dominate the entire response of devices, because most atoms are in interface/surface. Graphene/sapphire has great application electronic devices and semiconductor thin-film growth, but nature this interface is largely unknown. Here we find that sapphire surface a strong interaction with some carbon graphene to form C-O-Al configuration, indicating no longer simple van der Waals interaction. In addition, structural...