A5101610950- Cancer Cells and Metastasis
- Glycosylation and Glycoproteins Research
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Genomics and Diagnostics
- Pancreatitis Pathology and Treatment
- Nanoplatforms for cancer theranostics
- Pancreatic and Hepatic Oncology Research
- Single-cell and spatial transcriptomics
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Skin Protection and Aging
- Monoclonal and Polyclonal Antibodies Research
- Skin and Cellular Biology Research
- Galectins and Cancer Biology
- Acute Lymphoblastic Leukemia research
- Inflammatory Biomarkers in Disease Prognosis
- Immune Cell Function and Interaction
- Network Packet Processing and Optimization
- Microbial Metabolism and Applications
- Extracellular vesicles in disease
- Cancer Treatment and Pharmacology
- Hedgehog Signaling Pathway Studies
- Software-Defined Networks and 5G
- Dermatology and Skin Diseases
- Phagocytosis and Immune Regulation
Sichuan University
2011-2025
West China Hospital of Sichuan University
2008-2024
State Key Laboratory of Biotherapy
2011-2024
Changsha University of Science and Technology
2023
Abstract Recent evidences show that nervous system acts as a crucial part of cancer microenvironment. Infiltration nerve fibers into microenvironment has an important active role in progression. The stimulations both growth and metastasis by members such neurons glial cells have been demonstrated. However, how the is built largely unknown. Here we fraction stem (CSCs) derived from patients with gastric carcinoma colorectal are capable producing involved tumor neurogenesis growth. Cancer cell...
Nanoprobes that offer both fluorescence imaging (FI) and magnetic resonance (MRI) can provide supplementary information hold synergistic advantages. However, synthesis of such dual-modality probes simultaneously exhibit tunability functional groups, high stability, great biocompatibility desired results remains challenging. In this study, we used an amphiphilic block polymer from (ethylene glycol) methyl ether methacrylate (OEGMA) N-(2-hydroxypropyl) methacrylamide (HPMA) derivatives as a...
Tumor growth depends on the formation of blood vessels that provide supply nutrients and oxygen. Previous data have shown glioblastoma stem cells are able to give rise vascular constitute functional in tumor tissues. However, which kinds generated from is largely debated. In addition, there little evidence showing other tumors can produce Here we show cancer human colorectal carcinomas (Co CSC ) endothelial compose vasculatures The human‐cell‐specific nuclear antigen Nu MA + were detected...
Liver is the most common site of distant metastasis in colorectal cancer (CRC). Early diagnosis and appropriate treatment selection decides overall prognosis patients. However, current diagnostic measures were basically imaging but not functional. Circulating tumor cells (CTCs) known as hold key to understand biology metastatic mechanism provide a novel auxiliary strategy for CRC with liver (CRC-LM).The expression CD133+ CD133+CD54+CD44+ cellular subpopulations higher peripheral blood CRC-LM...
<title>Abstract</title> Backgroud: Limited research has explored the combined influence of dietary and lifestyle factors on testosterone levels. The Oxidative Balance Score (OBS) is a method used to evaluate level systemic oxidative stress. It indicates that higher scores are associated with greater exposure antioxidants.This study aims investigate probable association between OBS Methods A total 5168 male participants from 2013 2016 National Health Nutrition Examination Survey (NHANES) were...
Abstract In the previous study, we had showed expression of CD 133 + 54 44 cellular subpopulation circulating tumor cells ( CTC s) was significantly associated with liver metastasis colorectal cancer CRC ). This study aimed to explore whether this s have a prognostic value in patients. Flow cytometry used detect subpopulations 133, 54, and 152 patients, between December 2013 October 2014. The impact clinicopathological factors on overall survival were then analyzed. patients metastases who...
Abstract Fibroblasts and myofibroblasts are major mesenchymal cells in the lamina propria of colon mucosa cancer tissues. Detailed insight into highly specific populations fibroblasts is required to understand integrity homeostasis human cancer. Based on gene expression profiles single cells, we identified fibroblast that produce extracellular matrix components, Wnt ligand- BMP-secreting fibroblasts, chemokine- chemokine ligand-generating activated immune-modulating epithelial...
Red meat overconsumption is an unhealthy behavior, while its attributed burden and epidemiological pattern remain unclear. This study aimed to describe the status trend of how diet high in red burdens world.We accessed data summary exposure values (SEVs), deaths, disability-adjusted life years (DALYs) with their age-standardized rates each country from Global Burden Disease (GBD) Collaborative Network 1990 2019. We calculated estimated annual percentage changes (EAPCs) evaluate trends...
Background Growing evidence suggests that chronic inflammation, resulting from intricate immune system interactions, significantly contributes to the onset of psychiatric disorders. Observational studies have identified a link between immunoglobulin G (IgG) N-glycosylation and various conditions, but causality these associations remains unclear. Methods Genetic variants for IgG traits disorders were obtained published genome-wide association studies. The inverse-variance-weighted (IVW)...
B cell acute lymphoblastic leukemia (B-ALL) exhibits phenotypes reminiscent of normal stages B-cell development. As demonstrated by flow cytometry, the immunophenotypes are able to determine Multicolor cytometry (MFC) is more accurate at identifying populations. In this study, 9-color panels, including CD10, CD19, CD20, CD22, CD34, CD79a, CD179a, and IgM, which sequentially expressed during development, were designed detect subpopulations in adult B-ALL patients. 23 patients diagnosis, 192...
Abstract Da Cheng Qi decoction (DCQD) is composed of Dahuang, Houpu, Zhishi and Mangxiao. It a formula created under the theory Chinese medicine to purge ‘evil heat’ in gastrointestitinal tract, which arises from ileus acute pancreatitis. The present study was conducted evaluate herb–drug interaction between DCQD ranitidine, are often co‐administered clinical practice. Ranitidine administered orally alone or together with rats, plasma ranitidine concentrations were measured by HPLC....
This study aims to evaluate the frequency and absolute number of circulating innate lymphoid cell (ILC) subsets their associations with clinical serological features in systemic lupus erythematosus (SLE).We recruited 28 SLE patients (6 males, 22 females; mean age 37.57 years; range, 18 56 years) 13 healthy controls (4 9 32.08 19 48 years). Circulating ILC were identified by flow cytometry. Associations between all detected cells disease activity, manifestations, serum autoantibodies...
Abstract Background The detection and dissection of epidermal subgroups could lead to an improved understanding skin homeostasis wound healing. Flow cytometric analysis provides effective method detect the surface markers cells while producing high-dimensional data files. Methods A 9-color flow panel was optimized reveal heterogeneous in epidermis human skin. subsets were characterized using automated methods based on dimensional reduction approaches (viSNE) clustering with Spanning-tree...
Several nervous and nerve-related biomarkers have been detected in colorectal cancer (CRC) can contribute to the progression of CRC. However, role leucine-rich repeat neuronal 4 (LRRN4), a recently identified neurogenic marker, CRC remains unclear.We examined expression clinical outcomes LRRN4 from TCGA-COREAD mRNA-sequencing datasets immunohistochemistry Chinese cohort. Furthermore, colony formation, flow cytometry, wound healing assays mouse xenograft models were used investigate...
Aim: To investigate the count of circulating tissue factor-positive (TF + ) procoagulant microparticles (MPs) in patients with type 1 diabetes mellitus (T1DM). Methods: This case-control study included T1DM and age sex-matched healthy volunteers. The counts phosphatidylserine-positive (PS MPs TF PS subgroups derived from different cell types were measured peripheral blood sample two groups using multicolor flow cytometric assay. We compared each MP between as well ratio MPs/PS MPs). Results:...
In the present study, we have used plasmid-based RNA interference (RNAi) strategy to downregulate expression of epidermal growth factor receptor (EGFR) in EGFR wild-type (H292) and mutant (H1975) lung tumor models. The targeted knockdown by small hairpin not only inhibited H292 xenograft but also H1975 cancer cell xenograft, which bore L858R/T790M was resistant tyrosine kinase inhibitors. These data demonstrated that an effective therapy against EGFR-expressing cells thus considered be a...
Background: p73, a member of the p53 family, plays diverse roles in angiogenesis and cancer progression, likely due to heterogeneous functions its two primary isoforms, TAp73 DNp73. However, impact on endothelial trans-differentiation colorectal (CRC) stem cells (CoCSCs) remain largely uncharted.Methods: Samples data from Stockholm II trial, TCGA GEO were utilized investigate clinical significance p73. We employed endothelial-specific lineage tracing CoCSCs, RNA interference, overexpression...
Background While a few case-control studies indicated possible correlation of IgG N-glycosylation patterns with pancreatitis, their restricted sample sizes and methodologies prevented conclusive insights into causality or distinguishing traits across pancreatitis types. Method We conducted two-sample Mendelian Randomization (MR) analysis to investigate the causal relationship between 77 various types including acute (AP), chronic (CP), alcohol (AAP), (ACP). This utilized summary-level data...
Abstract Wnt/β-catenin signalling is aberrantly activated in most colorectal cancer (CRC) and one key driver involved the initiation progression of CRC. However, mutations APC gene CRC patients retain certain activity protein with decreased β-catenin DKK4 expression significantly upregulates represses human tissues, suggesting that a precisely modulated activation pathway essential for formation progression. The underlying reasons why specifically reduced degree, not fully activating are...