A5100365553- Dermatologic Treatments and Research
- Facial Rejuvenation and Surgery Techniques
- Wound Healing and Treatments
- Cancer-related molecular mechanisms research
- Burn Injury Management and Outcomes
- Body Contouring and Surgery
- melanin and skin pigmentation
- Injury Epidemiology and Prevention
- Kruppel-like factors research
- Nonmelanoma Skin Cancer Studies
- Cleft Lip and Palate Research
- Reconstructive Facial Surgery Techniques
- Dermatological and Skeletal Disorders
- Reconstructive Surgery and Microvascular Techniques
- Heat shock proteins research
- Mycobacterium research and diagnosis
- Cancer and Skin Lesions
- Polyomavirus and related diseases
- Acupuncture Treatment Research Studies
- Connective Tissue Growth Factor Research
- Restraint-Related Deaths
- Cutaneous Melanoma Detection and Management
- Breast Implant and Reconstruction
- Nasal Surgery and Airway Studies
- Cancer Immunotherapy and Biomarkers
Sichuan University
2016-2025
West China Hospital of Sichuan University
2016-2025
Jinan University
2024
Wuxi Ninth People's Hospital
2024
Soochow University
2024
Education University of Hong Kong
2024
Beijing Polytechnic
2024
BGI Research
2024
Guangdong Urban & Rural Planning and Design Institute
2023
Weifang Medical University
2023
Although surgical resection provides a straightforward and effective treatment for most malignant solid tumors, tumor recurrence acute postoperative pain continue to be two big problems associated with this treatment. To resolve these problems, nanocrystal composite slow-releasing ropivacaine doxorubicin was fabricated in study. Briefly, self-assembling peptide used form nanoparticle complexes the drugs, based on which homogeneous nanocrystals were obtained by adjusting pH. In cultured human...
The study developed an intelligent online evaluation system for mediolateral episiotomy, which incorporated machine learning algorithms and integrated maternal physiological data collected during delivery. In this study, a predictive model episiotomy was constructed first, based on this, early warning using open-source R software established. of 1191 parturients who delivered at Deyang People's Hospital in western China from January 2022 to December were divided into training set test...
Abstract Keloid and hypertrophic scars are difficult to manage remain a therapeutic challenge. Verapamil has shown great potential in the management of keloid scars. Comparing with conventional corticosteroid injections, verapamil could improve appearance scars, is associated lower incidence adverse effects. Is an effective alternative modality prevention treatment scars? The aim this study was assess effectiveness preventing treating Searches were conducted Medline, EMbase Cochrane...
Objective: Fibroblasts (FBs) are the cytological basis of keloid (KD) formation. This study aimed to identify key pathogenic target cell subpopulation involved in KD recurrence. Approach: Single-cell RNA sequencing data were retrieved from public databases, revealing distinct gene expression patterns FB subpopulations. Flow cytometry (FCM) was used surface molecular phenotypes FBs that affect Simultaneously, logistic regression analysis performed assess predictive value changes percentages...
This study aimed to explore the molecular mechanism of rubioncolin C(RuC) in inhibiting gastric cancer(GC). AGS and MGC803 cell lines were selected as cellular models. After treating cells with RuC at different concentrations, effects on proliferation ability GC assessed using CCK-8 method, real-time analysis(RTCA), colony formation assays. Transmission electron microscopy was used observe subcellular structural changes. Immunofluorescence applied detect LC3 fluorescent foci. Acridine orange...
Abstract A keloid is a benign fibroproliferative skin tumor that results from abnormal wound healing after injury and tends to grow beyond the boundary of original wound; mechanism formation still unclear. MicroRNA-21 (MiR-21) representative microRNA plays key role in variety fibrotic diseases via transforming growth factor-β/Smad signaling pathway. The aim our study was explore formation. First, we found expression miR-21 keloids fibroblasts significantly upregulated by microarray real-time...
Abstract Background It is important to determine the severity of inhalation injury in severely burned patients. The oxygenation index PaO 2 /FiO (PF) ratio a key clinical indicator injury. Sequential organ failure assessment (SOFA) developed assess acute incidence critical illness population. We hope provide an survival or prognostic factor for patients with based on respiratory SOFA score. Methods This retrospective cohort study all admissions Department Burn and Plastic Surgery at West...
Due to the accumulating evidence that has demonstrated vital role of cancer stem cells (CSCs) in tumor initiation, progression and metastasis, mechanisms maintain stemness CSCs have attracted increasing attention. Metastasis‑associated lung adenocarcinoma transcript‑1 (MALAT‑1), a long non‑coding RNA, which been revealed be associated with malignant behavior tumors, performs critical maintaining several CSCs. In present study, it was hypothesized MALAT‑1 promotes cell‑like phenotypes breast...
Hyperproliferation of fibroblasts is the main cause keloid formation. However, pathogenesis keloids has yet to be fully elucidated. Tumor necrosis factor (TNF)‑α may play an important role in formation and proliferation keloids, as it implicated various fibrous disorders. In present study, expression level TNF‑α its receptors, soluble TNF receptor (sTNFR)1 sTNFR2, peripheral blood skin tissues was detected by ELISA, reverse transcription‑quantitative PCR or immunohistochemistry. There no...
The visual landscape influences the soundscape experience of urban public spaces. purpose this study is to analyze relationships among factors and evaluation old residential areas determine their main influencing factors. In Tianjin, China, six typical were selected collect sound video information. Virtual reality (VR) was used create an environment, subjective evaluations accessed through questionnaire (N = 256). results show that satisfaction central square in area superior space along...
Abstract In keloid fibroblasts, microRNA-21 (miR-21) enhances activation of the TGF-β–Smad signaling pathway by down-regulating Smad7 expression, thereby promoting fibroblast proliferation and collagen production. However, it is unclear whether miR-21 performs above-mentioned functions through exosomal transport. Here, we extracted exosomes from culture supernatants normal skin fibroblasts observed that both types cells above secrete exosomes; however, secreted significantly more than (P...
Mast cells play a significant role in the late stage of wound healing following burn injuries. In present study, possible mast cell chymase was examined using membrane stabilizer, ketotifen, hamsters. A total 28 hamsters were randomly divided into two groups (n=14), termed as control and ketotifen groups. deep partial-thickness injury made on back skin The group orally administered physiological saline (1 ml) (4 mg/kg) once daily, days prior to subsequent burn. results showed that...
Background Keloid is a proliferative disease of fibrous tissues. The mechanism and consistently effective treatments keloid remained unknown. Although there was report about treating with topical captopril, the further investigation captopril affecting has not been performed so far. Objectives aim this study to analyse effect on collagen metabolisms in fibroblast cells, provide information for therapy keloid. Methods To investigate effects relative we examined changes metabolism, expression...
Abstract Aggressive natural killer cell leukemia/lymphoma (ANKL) is a rare aggressive form of NK-cell neoplasm. We report an uncommon case 36-year-old male who showed jaundice and spontaneous splenic rupture. The diagnosis was established by the biopsy liver spleen. monomorphous medium-size neoplastic cells infiltrated into portal areas sinus as well cords Necrosis, mitotic figures significant apoptosis could be seen easily. These demonstrated typical immunophenotype CD3ε+, CD56+, CD16+,...