A5039677416- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Adenosine and Purinergic Signaling
- Immune cells in cancer
- Circular RNAs in diseases
- Reproductive System and Pregnancy
- Glycosylation and Glycoproteins Research
- T-cell and B-cell Immunology
- Mesenchymal stem cell research
- Bone Metabolism and Diseases
- Extracellular vesicles in disease
- Photoacoustic and Ultrasonic Imaging
- Macrophage Migration Inhibitory Factor
- Gene Regulatory Network Analysis
- Vascular anomalies and interventions
- Ionic liquids properties and applications
- Monoclonal and Polyclonal Antibodies Research
Sichuan University
2013-2025
First Affiliated Hospital of Bengbu Medical College
2017-2024
Virginia–Maryland College of Veterinary Medicine
2015-2024
Virginia Tech
2014-2024
West China Medical Center of Sichuan University
2013-2024
China Three Gorges University
2024
West China Hospital of Sichuan University
2021-2024
State Key Laboratory of Biotherapy
2016-2023
Toronto Public Health
2023
China Pharmaceutical University
2019-2022
Abstract Self-assembling natural drug hydrogels formed without structural modification and able to act as carriers are of interest for biomedical applications. A lack knowledge about gels limits there current application. Here, we report on rhein, a herbal product, which is directly self-assembled into through noncovalent interactions. This hydrogel shows excellent stability, sustained release reversible stimuli-responses. The consists three-dimensional nanofiber network that prevents...
Abstract Recent evidences show that nervous system acts as a crucial part of cancer microenvironment. Infiltration nerve fibers into microenvironment has an important active role in progression. The stimulations both growth and metastasis by members such neurons glial cells have been demonstrated. However, how the is built largely unknown. Here we fraction stem (CSCs) derived from patients with gastric carcinoma colorectal are capable producing involved tumor neurogenesis growth. Cancer cell...
Abstract mRNA vaccines have emerged rapidly in recent years as a prophylactic and therapeutic agent against various diseases including cancer infectious diseases. Improvements of been underway, among which boosting efficacy is great importance. Pam2Cys, simple synthetic metabolizable lipoamino acid that signals through Toll-like receptor (TLR) 2/6 pathway, eliciting both humoral cellular adaptive immune responses, an interesting candidate adjuvant. To investigate the enhancement efficacies...
Accumulating evidence indicates that cancer-initiating cells (CICs) are responsible for cancer initiation, relapse, and metastasis. Colorectal carcinoma (CRC) is typically classified into proximal colon, distal rectal cancer. The gradual changes in CRC molecular features within the bowel may have considerable implications colon CICs. Unfortunately, limited information available on CICs derived from cancer, although been described. Here we identified (R-CICs) possess differentiation potential...
<title>Abstract</title> Backgroud: Limited research has explored the combined influence of dietary and lifestyle factors on testosterone levels. The Oxidative Balance Score (OBS) is a method used to evaluate level systemic oxidative stress. It indicates that higher scores are associated with greater exposure antioxidants.This study aims investigate probable association between OBS Methods A total 5168 male participants from 2013 2016 National Health Nutrition Examination Survey (NHANES) were...
There are conflicting epidemiologic data on whether chronic aspirin (ASA) use may reduce melanoma risk in humans. Potential anticancer effects of ASA be mediated by its ability to suppress prostaglandin E2 (PGE2) production and activate 5'-adenosine monophosphate-activated protein kinase (AMPK). We investigated the inhibitory a panel transformed melanocyte cell lines, tumor growth preclinical model. COX-2 inhibitor celecoxib did not affect viability, but significantly reduced colony...
Tumor growth depends on the formation of blood vessels that provide supply nutrients and oxygen. Previous data have shown glioblastoma stem cells are able to give rise vascular constitute functional in tumor tissues. However, which kinds generated from is largely debated. In addition, there little evidence showing other tumors can produce Here we show cancer human colorectal carcinomas (Co CSC ) endothelial compose vasculatures The human‐cell‐specific nuclear antigen Nu MA + were detected...
Epigenetic factors such as DNA methylation and microRNAs (miRNAs) are now increasingly recognized vital contributors to lupus etiology. In this study, we investigated the potential interaction of these two epigenetic in lupus-prone MRL-lpr mice. We recently reported dysregulated expression miRNAs splenocytes Here, report that a majority upregulated mice is located at genomic imprinted DLK1-Dio3 domain. Further, show differential magnitude upregulation miRNA cluster purified splenic CD4+ T,...
Polarization of low-grade inflammatory monocytes facilitates the pathogenesis atherosclerosis. However, underlying mechanisms as well approaches for resolving monocyte polarization conducive to regression atherosclerosis are not established. In this report, we demonstrate that TRIF-related adaptor molecule (TRAM) mediated in vivo and vitro. TRAM controlled through activating Src family kinase c-SRC, which only induces STAT1/STAT5-regulated mediators CCR2 SIRP-α but also suppresses...
Abstract An efficient in situ ionic liquid dispersive liquid–liquid microextraction followed by ultra‐performance chromatography was developed to determine four neonicotinoid insecticides wild and commercial honey samples. In this method, a hydrophobic 1‐butyl‐3‐methylimidazolium hexafluorophosphate, formed reaction between potassium hexafluorophosphate bromide sample solution, used as the extraction solvent. comparison with traditional method required no To achieve high efficiency...
Aim: To investigate the association and prognostic value of ANKZF1 gene for survival in colorectal cancer, mechanism level alteration correlated signaling pathways is involved. Patients & methods: The Cancer Genome Atlas COREAD dataset was analyzed by bioinformatical investigation. Results: High expression associated with poor overall (hazard ratio [HR]: 2.094; 95% CI: 1.188–3.689; p = 0.011) recurrence-free (HR: 1.762; 1.021–3.042; 0.042) colon cancer. Bioinformatical analysis showed...
Commensal bacteria and the immune system have a close strong relationship that maintains balance to control inflammation. Alterations of microbiota, known as dysbiosis, can direct reactivity self-antigens not only in intestinal mucosa but also at systemic level. Our laboratory previously reported gut particularly lower abundance family Lactobacillaceae, lupus-prone MRL/lpr mice, model autoimmunity. Restoring microbiota with mix 5 different Lactobacillus species (spp.), L. reuteri, oris,...
Abstract Syndecan-4 (Syn4), a single-pass transmembrane heparin sulphate proteoglycan (HSPG), plays significant role in the formation of focal adhesions and interacts with many growth factors to regulate cell migration neural induction. Here, we show new roles syndecan-4 ( syn4 ) zebrafish embryonic neurogenesis. Syn4 is broadly dynamically expressed throughout early stages development. Knockdown increases expression marker genes multiple types cells. The increased resulted from excessive...
Abstract The main aim of our study was to investigate the roles and molecular basis long noncoding RNA myocardial infarction associated transcript (MIAT) in development thoracic aortic aneurysm. RT‐qPCR assay performed measure expressions MIAT, microRNA‐145 (miR‐145), along with Bcl‐2 Bcl‐xl messenger RNAs. Western blot conducted determine protein levels Bcl‐2, Bcl‐xl, phosphorylated‐Akt (p‐Akt), total Akt (t‐Akt). Cell viability detected by...
Background: Mesenchymal stem cells (MSCs) have shown great potential in the treatment of cardiovascular diseases, with fat being a more accessible source MSCs. This study investigated effect human adipose-derived mesenchymal (hMSCs-Ad) exosomes on T lymphocytes and its role atherosclerosis (AS).