A5021349883- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Advanced Drug Delivery Systems
- Natural product bioactivities and synthesis
- Supramolecular Self-Assembly in Materials
- Immune Cell Function and Interaction
- Peroxisome Proliferator-Activated Receptors
- Histone Deacetylase Inhibitors Research
- Pharmacological Effects of Medicinal Plants
- Hops Chemistry and Applications
- MicroRNA in disease regulation
- Swearing, Euphemism, Multilingualism
- Circular RNAs in diseases
- Inflammatory mediators and NSAID effects
- RNA Research and Splicing
- Chromatography in Natural Products
- Ferroptosis and cancer prognosis
- Long-Term Effects of COVID-19
- RNA modifications and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Curcumin's Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Ginseng Biological Effects and Applications
- Immune Response and Inflammation
Central South University
2016-2024
Second Xiangya Hospital of Central South University
2021-2024
Changsha Medical University
2024
Hunan University of Traditional Chinese Medicine
2019-2022
Henan University of Traditional Chinese Medicine
2021
Hunan University
2021
Xiangya Hospital Central South University
2016-2020
Abstract Self-assembling natural drug hydrogels formed without structural modification and able to act as carriers are of interest for biomedical applications. A lack knowledge about gels limits there current application. Here, we report on rhein, a herbal product, which is directly self-assembled into through noncovalent interactions. This hydrogel shows excellent stability, sustained release reversible stimuli-responses. The consists three-dimensional nanofiber network that prevents...
BackgroundHematopoietic cell signal transducer (HCST) and tyrosine kinase-binding protein (TYROBP) are triggering receptors expressed on myeloid cells 2 (TREM2), which pivotal in the immune response to disease. Despite growing evidence underscoring significance of TREM2, HCST, TYROBP certain forms tumorigenesis, a comprehensive pan-cancer analysis these proteins is lacking.MethodsMultiple databases were synthesized investigate relationship between TYROBP, various cancer types. These include...
Curcumin, one of the active ingredients <em>Curcuma longa</em> (Jianghuang), has been reported to exert multiple bioactivities, including pro‑apoptotic and anti‑inflammatory activities. In recent years, curcumin extensively studied, it revealed that inhibits growth numerous types cancer. However, best our knowledge, inhibitory effects on activation or expansion myeloid‑derived suppressor cells (MDSCs) in liver cancer underlying mechanism have not yet determined. Therefore, present study...
Traditional Chinese medicine, JianpiJiedu decoction (JPJDF), has been utilized in colorectal cancer (CRC) treatment for over forty years. The potential of JPJDF to inhibit CRC through modulation intestinal microbiota and their metabolites remains uncertain.
Buyang Huanwu Decoction (BHD) is a traditional Chinese herbal medicine that effective for treating cerebral ischemia (CI). However, the molecular mechanisms of BHD in CI have not been fully elucidated. In this study, we integrated circular RNA (circRNA)-microRNA (miRNA)-messenger (mRNA) network middle artery occlusion (MACO) rats treated with BHD.SD were randomly divided into control group, model model+BHD group (2.5, 5, 10 g/kg) and model+butylphthalide (NBP) (54 mg/kg). The neurological...
In traditional Chinese medicine (TCM), frankincense and myrrh are the main components of antitumor drug Xihuang Pill. These compounds show anticancer activity in other biological systems. However, whether and/or can inhibit occurrence hepatocellular carcinoma (HCC) is unknown, potential molecular mechanism(s) has not yet been determined.To predict determine latent anti-HCC therapeutic targets mechanisms vivo.In present study, which was based on Traditional Medicine Systems Pharmacology...
Rhein (4,5-dihydroxyanthraquinone-2-carboxylic acid) is an anthraquinone compound mainly isolated from the herbal medicine rhubarb. It possesses a wide spectrum of pharmacological effects. However, lack sustained release properties and poor bioavailability hinder clinical transformation. Hydrogel-based drug delivery system provides ideal carrier to improve control therapeutic efficacy drugs. Herein, we present chitosan hydrogel for rhein. This rhein–chitosan (CS–Rh gel) exhibited superior...
Chinese medicine syndrome diagnosis is the key requisite in treatment of male infertility with traditional (TCM). Kidney-Yang deficiency (KYDS) critical infertility. To explore modernized mechanisms KYDS infertility, this study aims to investigate metabolomics males KYDS. The gas chromatography-mass spectrometry method was applied analyze plasma samples 67 infertile compared 55 age-matched healthy controls. chemometric methods including principal component and partial least...
As a bioactive absorbed compound of rhubarb, Rhein is applied for the treatment brain injury. However, underlying pharmacological mechanisms remain unclear. In this study, we aimed to explore antineuroinflammatory functions and in vitro. BV2 microglia cells were chosen irritated by LPS. The influence on cell viability was determined using MTT assay. We finely gauged proinflammatory cytokines TNF‐ α IL‐1 β through tests immunofluorescence staining, ELISA, RT‐qPCR, western blot. Additionally,...
The phosphoinositide 3-kinase/protein kinase-B/mechanistic target of rapamycin (PI3K/Akt/mTOR) signalling pathway is crucial for cell survival, differentiation, apoptosis and metabolism. Xihuang pills (XHP) are a traditional Chinese preparation with antitumour properties. They inhibit the growth breast cancer, glioma, other tumours by regulating PI3K/Akt/mTOR pathway. However, effects mechanisms action XHP in hepatocellular carcinoma (HCC) remain unclear. Regulation effectively inhibits...
Background: Triggering receptor expressed on myeloid cells 2 (TREM2), hematopoietic cell signal transducer (HCST), and TYRO protein tyrosine kinase-binding (TYROBP) serve as pivotal elements within the immune response to disease. Despite growing evidence underscoring significance of TREM2, HCST, TYROBP in certain forms tumorigenesis, a comprehensive pan-cancer analysis these remains absent.Methods: A synthesis multiple databases facilitated an investigation into relationship between...
Abstract Background: The FK506-binding protein 4 ( FKBP4 ), a tumor-related gene, plays vital role in tumorigenesis and cancer progression. study is aimed to clarify the effect of lung adenocarcinoma (LUAD). Methods: Relying on Cancer Genome Atlas (TCGA) cohort, expression difference between LUAD tissues non-tumor was first detected, verified with public tissue microarrays (TMAs), clinical specimen cohort Gene Expression Omnibus (GEO) cohort. Then, logistic regression analysis chi-square...