A5036511960- Immune cells in cancer
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune responses and vaccinations
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Phagocytosis and Immune Regulation
- MicroRNA in disease regulation
- Single-cell and spatial transcriptomics
- Chemokine receptors and signaling
- Autophagy in Disease and Therapy
- Rangeland Management and Livestock Ecology
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Systemic Lupus Erythematosus Research
- Cell death mechanisms and regulation
- Fungal Plant Pathogen Control
- Nanoparticle-Based Drug Delivery
- Cancer-related Molecular Pathways
- Aquaculture Nutrition and Growth
- Meat and Animal Product Quality
- Gestational Trophoblastic Disease Studies
- Immunotherapy and Immune Responses
- Fibroblast Growth Factor Research
Fudan University
2024-2025
State Key Laboratory of Medical Neurobiology
2024
Virginia Tech
2015-2024
China-Japan Friendship Hospital
2024
Renmin University of China
2023-2024
Beijing Jiaotong University
2024
Northwest A&F University
2023-2024
Institute of Zoology
2007-2023
Chinese Academy of Sciences
2007-2023
University of Chinese Academy of Sciences
2007-2023
Abstract Here we show that iNOS-deficient mice display enhanced classically activated M1 macrophage polarization without major effects on alternatively M2 macrophages. eNOS and nNOS mutant comparable compared with wild-type control mice. Addition of N6-(1-iminoethyl)-L-lysine dihydrochloride, an iNOS inhibitor, significantly enhances while S-nitroso-N-acetylpenicillamine, a NO donor, suppresses polarization. derived from mediates nitration tyrosine residues in IRF5 protein, leading to the...
Abstract Sustained low-grade inflammation mediated by non-resolving inflammatory monocytes has long been suspected in the pathogenesis of atherosclerosis; however, molecular mechanisms responsible for sustainment during atherosclerosis are poorly understood. Here we observe that subclinical endotoxemia, often seen humans with chronic inflammation, aggravates murine through programming into a state elevated Ly6C, CCR5, MCP-1 and reduced SR-B1. The is due to disruption homeostatic tolerance...
Abstract Oestrogen is known to be strongly associated with ovarian cancer. There was much work show the importance of lncRNA SNHG17 in However, no study has revealed molecular regulatory mechanism and functional effects between oestrogen development metastasis In this study, we found that expression significantly increased cancer positively correlated treatment. could promote M2 macrophage polarization as well cells SKOV3 ES2 cell exosomal expression. When exposure oestrogen, promoted...
Dynamically reprogrammed neutrophils serve as critical initiators for the pathogenesis and treatment of atherosclerosis.
Pathogenic inflammation and immuno-suppression are cardinal features of exhausted monocytes increasingly recognized in septic patients murine models sepsis. However, underlying mechanisms responsible for the generation have not been addressed. In this report, we examined primary through prolonged repetitive challenges with high dose bacterial endotoxin lipopolysaccharide (LPS). We demonstrated that LPS skew into classically Ly6C hi population, deplete homeostatic non-classical lo reminiscent...
Emerging studies suggest that monocytes can be trained by bacterial endotoxin to adopt distinct memory states ranging from low-grade inflammation immune exhaustion. While may contribute the pathogenesis of chronic diseases, exhausted with pathogenic and immune-suppressive characteristics underlie polymicrobial sepsis including COVID-19. However, detailed processes which dynamic adaption occur remain poorly understood. Here we exposed murine bone-marrow derived lipopolysaccharide (LPS)...
Subclinical super-low-dose endotoxin LPS is a risk factor for the establishment of low-grade inflammation during pathogenesis and progression chronic diseases. However, underlying mechanisms are not well understood. At cellular level, disruption lysosome fusion with endosomes or autophagosomes may contribute to potentiation inflammation. In this study, we identified that subclinical can potently inhibit process endosome acidification in primary macrophages. Super-low-dose induced inhibitory...
Impaired wound healing often accompanies low-grade inflammatory conditions, during which circulating levels of subclinical super-low-dose endotoxin may persist. Low-grade monocyte polarization occur chronic inflammation and deter effective repair. However, little is understood about the potential mechanisms by sustained insult endotoxin. We observed that preferentially programmes a state in vitro vivo, as represented elevated population CD11b(+) Ly6C(high) monocytes expression CCR5....
Abstract Rapid enhancement of phagocyte functionality is a hallmark neutrophil priming. GeneChip analyses unveiled elevated CD54, dectin-2, and IL-1β mRNA expression by neutrophils isolated from inflammatory sites. In fact, CD54 dectin-2 protein was detected on recovered skin, peritoneal, lung inflammation lesions but not those in bone marrow or peripheral blood. Neutrophils increased during migration Boyden chambers acquired surface after subsequent exposure to GM-CSF. purified...
In adaptation to rising stimulant strength, innate monocytes can be dynamically programed preferentially express either pro- or anti-inflammatory mediators. Such dynamic programing may bear profound relevance in host health and disease. However, molecular mechanisms that govern varying strength of stimulants are not well understood. Using lipopolysaccharide (LPS), the model toll-like-receptor 4 (TLR4), we reported expressions pro-inflammatory mediators sustained adapted by lower doses LPS,...
Compromised lipophagy with unknown mechanisms may be critically involved in the intracellular accumulation of lipids, contributing to elevated atherosclerosis and liver steatosis. We hypothesize that toll-interacting protein (Tollip), a key innate immune molecule fusion autolysosome, play significant role modulate lipid during pathogenesis
Abstract Background Exercise-related signaling Fndc5/irisin expresses in brain and acts as a crucial regulator of cognitive function, but its detailed roles vascular dementia (VaD) are still unclear. Low intensity pulsed ultrasound (LIPUS), novel stimulation approach, has been suggested promising treatment for dementia. Here, we investigated the activity efficacy experimental VaD, further explored whether potential effects LIPUS on VaD is related to Fndc5/irisin. Methods Mouse model was...
Abstract Apart from the blood‐brain barrier (BBB), efficacy of immunotherapy for glioblastoma (GBM) is limited by presence intrinsic and adaptive immune resistance, implying that co‐delivery various immunotherapeutic agents or simultaneous regulation different cells urgently needed. Bacterial outer membrane vesicles (OMVs) offer a unique advantage in treatment GBM, owing to their multifunctional properties as carriers adjuvants ability cross BBB. However, traditional OMVs can lead toxic side...
Background: It has been reported that ultrasound enhances peripheral nerve regeneration, but the mechanism remains elusive. Low-intensity pulsed (LIPUS) to enhance proliferation and alter protein production in various types of cells. In this study, we detected effects LIPUS on Schwann Material methods: cells were separated from new natal Sprague-Dawley rat sciatic nerves cultured purified. The treated by for 10 minutes every day, with an intensity 27.37 mW/cm2. After treatment 5 days, MTT,...
Super-low-dose endotoxemia in experimental animals and humans is linked to low-grade chronic inflammatory diseases. However, the underlying molecular cellular mechanisms are not well understood. In this study, we examined effects of a super-low dose LPS on inflammation macrophages as mechanisms. We observed that induces mitochondrial fission cell necroptosis primary murine macrophages, dependent upon interleukin 1 receptor-associated kinase (IRAK-1). Mechanistically, our study reveals causes...
Abstract Subclinical circulating bacterial endotoxin LPS has been implicated as an important cofactor in the development and progression of nonalcoholic steatohepatitis, but underlying mechanisms remain unclear. In this study, we demonstrated that 4-wk injection with superlow-dose significantly promoted neutrophil infiltration accelerated steatohepatitis progression, including exacerbated macrovesicular steatosis, inflammation, hepatocyte ballooning high-fat diet–fed apolipoprotein E...
Although the importance of tumor immune environment for modulation tumorigenesis and regression is becoming increasingly clear, most research related to tumor-immune therapies has focused on adaptive cells, while role regulation innate leukocytes such as neutrophils remains controversial less defined. Here we observed that selective deletion Tollip, a key immune-cell modulator, led enhanced surveillance in chemically induced colorectal cancer model. Tollip-deficient significantly elevated T...
Fibroblast growth factor 1 (FGF1) regulates vertebrate cell growth, proliferation and differentiation, energy metabolism. In this study, we cloned rainbow trout (Oncorhynchus mykiss) fgf1 fgf1a, prepared their recombinant proteins (rFGF1 rFGF1a), described the molecular mechanisms by which they improve glycolipid metabolism in carnivorous fish. A 31-day feeding trial was conducted to investigate whether could enhance on high-carbohydrate diets (HCD). The 720 (8.9 ± 0.5 g) were equally...