A5024016470- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- HIV, Drug Use, Sexual Risk
- Dental Implant Techniques and Outcomes
- Immune Response and Inflammation
- HIV/AIDS Research and Interventions
- Dental materials and restorations
- Mycotoxins in Agriculture and Food
- Nanoparticles: synthesis and applications
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Electrospun Nanofibers in Biomedical Applications
- Sex work and related issues
- Cytokine Signaling Pathways and Interactions
- Immunotherapy and Immune Responses
- Biosensors and Analytical Detection
- Peripheral Artery Disease Management
- Periodontal Regeneration and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Adhesion Molecules Research
- Advancements in Battery Materials
- Supramolecular Self-Assembly in Materials
- Adolescent Sexual and Reproductive Health
McGill University
2024
First Affiliated Hospital of Bengbu Medical College
2022-2024
Capital Medical University
2013-2024
Shenyang Agricultural University
2024
Qingdao University
2021-2023
Tianjin University of Science and Technology
2021-2022
Cells Therapy (Poland)
2022
Peking University First Hospital
2021
Peking University
2021
Yunnan Center for Disease Control And Prevention
2010-2018
Objective: To investigate the characteristics and trends in HIV epidemic Yunnan province, China, between 1989 2007. Methods: Statistical analysis of serological data from voluntary testing counseling sites, medical case reports, mass screenings, sentinel surveillance, other sources. Results: By 2007, a cumulative total 57,325 cases infection were reported Yunnan, unsafe drug injection practices sexual behaviors identified as dominant modes transmission. affects injecting users most,...
Prevention of implant-associated infections at an early stage surgery is highly desirable for the long-term efficacy implants in dentistry and orthopedics. Infection prophylaxis using conventional antibiotics becoming less effective due to development bacteria resistant multiple antibiotics. An ideal strategy conquer bacterial local delivery antibacterial agents. Therefore, antimicrobial peptide (AMP) eluting coatings on implant surfaces a promising alternative. In this study, feasibility...
Abstract Poly-ether-ether-ketone (PEEK) has attracted increasing attention as a promising orthopaedic implant material owing to its excellent mechanical properties and biocompatibility. However, antibacterial must be improved an material. In this study, PEEK was sulfonated obtain porous surface, graphene oxide (GO) deposited form coating with activity After for different durations, GO on the surface prepare (SPEEK-GO), which then characterised using scanning electron microscopy (SEM), Raman...
Abstract Rapid enhancement of phagocyte functionality is a hallmark neutrophil priming. GeneChip analyses unveiled elevated CD54, dectin-2, and IL-1β mRNA expression by neutrophils isolated from inflammatory sites. In fact, CD54 dectin-2 protein was detected on recovered skin, peritoneal, lung inflammation lesions but not those in bone marrow or peripheral blood. Neutrophils increased during migration Boyden chambers acquired surface after subsequent exposure to GM-CSF. purified...
Macrophages are attracting increasing attention in promoting implant-mediated osteogenesis by modulating the microenvironment of implant site. Biomaterial surface properties including topography and wettability regulate macrophage responses to influence tissue repair. The objective our present study was investigate effects hydrogenated titanium dioxide nanotube surfaces on immune response macrophages vitro. Hydrogenated nanotubes (TNTs) were synthesized Ti anodic oxidation hydrogenation form...
The study aim was to evaluate the effect of micro-arc oxidation (MAO) and alkali treatment on porous tantalum specimens by foam immersion technology. Tantalum modified MAO formed an apatite layer their surfaces in simulated body fluid (SBF). However, leach liquor these shows toxicity 3T3-E1 cells. When they were previously soaked a 0.5 M NaOH aqueous solution at 60 °C for 24 h, there no statistical difference between with pretreatment control cell proliferation experiments. NaOH-treated...
Modified titanium (Ti) substrates with dioxide (TiO2) nanotubes have broad usage as implant surface treatments and drug delivery systems.To improve drug-loading capacity accelerate bone integration titanium, in this study, we hydrogenated anodized (TNTs) by a thermal treatment. Three groups were examined, namely: TNTs (H2-TNTs, test), unmodified (air-TNTs, control), Ti (Ti, control).Our results showed that oxygen vacancies present all the nanotubes. The quantity of -OH greatly increased...
Soft tissue integration is critical for the long-term retention of dental implants. The surface properties including topography and wettability can impact soft sealing. In our work, a thermal hydrogenation technique was applied to modify anodized titanium dioxide nanotubes (TNTs). However, effects hydrogenated on soft-tissue cells remain unclear. aim present study investigate bioactivities human gingival fibroblasts (HGFs) structured surfaces, which determine early formation Three groups...
Diabetic lower limb ischemia is an intractable disease that leads to amputation and even death. Recently, adipose-derived stem cell-secreted exosomes (ADSC-Exo) have been reported as a potential therapeutic approach, but its specific mechanism of action unknown. Studies found derived from cells can reduce inflammation promote tissue repair. Macrophages play important role in the development repair ischemic tissue, regulation ADSC-Exo macrophages has rarely reported. The present study aimed...
Abstract Multiple human immunodeficiency virus (HIV)-1 genotypes in China were first discovered Yunnan Province before disseminating throughout the country. As HIV-1 epidemic continues to expand Yunnan, genetic characteristics and transmitted drug resistance (TDR) should be further investigated among recently infected population. Among 2828 HIV-positive samples newly reported quarter of 2014, 347 identified as recent infections with BED-captured enzyme immunoassay (CEIA). Of them, 291...
Titanium-based implants are often utilized in oral implantology and craniofacial reconstructions. However, the biological inertness of machined titanium commonly results unsatisfactory osseointegration. To improve osseointegration properties, we modified with nanotubular/superhydrophilic surfaces through anodic oxidation thermal hydrogenation evaluated effects (M), nanotubular (Nano), hydrogenated nanotubes (H-Nano) on osteogenesis vitro vivo. After incubation mouse bone marrow mesenchymal...
It is well established that nanotopography and wettability of implant surfaces contribute to osseointegration long-term success. However, the effects a hydrogenated surface with nanotubular superhydrophilic properties on peri-implant soft tissue remain unclear. This study was designed impact modified abutment early integration compared machined surface.Thirty-six implants were placed at bone level in bilateral mandible six beagles, followed by healing abutments belonging standard Ti-6Al-4V...
Chrysin (CHR) is a flavonoid with extensive pharmacological activity. The molecular formula of CHR C15 H10 O4 . reported to have antioxidative, antitumour and antiviral functions. To evaluate its potential function as vaccine adjuvant, we prepared melanoma using soluble protein extract B16F10 cells antigen an adjuvant. model was developed after two immunizations, it discovered that combining antigen-mixed could inhibit tumour growth in the mouse model, overall survival rate higher than...
Neutrophils contribute to innate host immunity by functioning as professional phagocytes, whereas dendritic cells (DCs) are prototypic antigen presenting (APCs) responsible for the induction of adaptive immune responses. We have demonstrated recently that neutrophils trans-differentiate into a unique population, termed “neutrophil-DC hybrids,” expressing surface markers both and DCs exhibiting dual functionality phagocytes APCs. Although hybrid emerged in significant numbers murine bone...
Abstract Stem and progenitor cell mitosis is essential for tissue development homeostasis. How these cells ensure proper chromosome segregation, thereby maintain mitotic fidelity, in the complex physiological environment of a living animal poorly understood. Here we use situ live-cell imaging C. elegans germline stem (GSPCs) to ask how signaling influences vivo . Through candidate screen identify new role insulin/IGF receptor (IGFR), daf-2, during GSPC mitosis. Mitosis delayed daf-2/ IGFR...
Stem and progenitor cell mitosis is essential for tissue development homeostasis. How these cells ensure proper chromosome segregation, thereby maintain mitotic fidelity, in the complex physiological environment of a living animal poorly understood. Here we use situ live-cell imaging C . elegans germline stem (GSPCs) to ask how signaling influences vivo Through candidate screen identify new role insulin/IGF receptor (IGFR), daf-2 , during GSPC mitosis. Mitosis delayed daf-2/ IGFR mutants,...