A5077904151- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Cancer Immunotherapy and Biomarkers
- Endoplasmic Reticulum Stress and Disease
- Liver Disease Diagnosis and Treatment
- Cancer Cells and Metastasis
- Autophagy in Disease and Therapy
- Liver physiology and pathology
- Ferroptosis and cancer prognosis
- Urban Green Space and Health
- Diet, Metabolism, and Disease
- Neuroinflammation and Neurodegeneration Mechanisms
- CAR-T cell therapy research
- Adenosine and Purinergic Signaling
- interferon and immune responses
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Enhanced Oil Recovery Techniques
- Neonatal Health and Biochemistry
- Essential Oils and Antimicrobial Activity
- Circadian rhythm and melatonin
- Cancer-related molecular mechanisms research
- Gut microbiota and health
Qingdao University
2016-2024
Xi'an Honghui Hospital
2024
Xi'an Jiaotong University
2024
Shuguang Hospital
2022-2024
Shanghai University of Traditional Chinese Medicine
2022-2024
Yantai University
2024
Second Affiliated Hospital of Dalian Medical University
2023-2024
Xiangya Hospital Central South University
2020-2024
Central South University
2020-2024
Dalian Medical University
2024
Metabolic diseases are often associated with high fructose (HF) consumption. HF has also been found to alter the gut microbiota, which then favors development of nonalcoholic fatty liver disease. However, mechanisms underlying microbiota on this metabolic disturbance yet be determined. Thus, in study, we further explored effect concerning T cells balance an diet mouse model. We fed mice 60% fructose-enriched for 12 weeks. At 4 weeks, did not affect liver, but it caused injury intestine and...
Hesperetin (HES) is a dihydroflavone with the molecular formula of C16H14O6. It has been reported that antioxidant and anticancer effects. Recent studies showed it can also regulate immune responses. To assess its potential function as vaccine adjuvant, we formulated HES inactivated B16F10 melanoma cells determined whether would enhance activation antigen-presenting by experiments in vivo vitro. We found activated PI3K-Akt signalling pathway (APCs), enhanced cytotoxic T lymphocyte (CTL)...
The rise of superbugs underscores the urgent need for novel antimicrobial agents. Antimicrobial peptides (AMPs) have ability to kill regardless resistance traditional antibiotics. However, AMPs often display a lack efficacy in vivo. Sequence optimization and engineering are promising but may result increased host toxicity. We report here AMP (α4-short) derived from multifunctional respiratory protein SPLUNC1. α4-short demonstrated broad-spectrum activity against as well vivo P. aeruginosa...
Glioblastoma multiforme (GBM), a highly malignant invasive brain tumor, is associated with poor prognosis and survival lacks an effective cure. High expression of the human cytomegalovirus (HCMV) immediate early protein 1 (IE1) in GBM tissues strongly their progression, presenting novel target for therapeutic strategies. Here, bioluminescence imaging technology revealed remarkable tumor shrinkage improved rates mouse glioma model treated HCMV IE1/IE1mut vaccine. In addition,...
Background: Kidney renal clear cell carcinoma (KIRC) is a common and clinically significant subtype of kidney cancer. A potential therapeutic target in KIRC disulfidptosis, novel mode death induced by disulfide stress. The aim this study was to develop prognostic model explore the clinical significance different disulfidptosis gene typings from KIRC. Methods: comprehensive analysis chromosomal localization, expression patterns, mutational landscape, copy number variations, 10 genes...
Low-ambient temperature environment exposure increased the risk of cardiovascular morbidity and mortality, although underlying mechanism remains unclear. This study was designed to examine impact cardiac overexpression metallothionein, a cysteine-rich heavy metal scavenger, on low (4°C)-induced changes in myocardial function involved, with focus autophagy. Cold (4°C for 3 wk) promoted oxidative stress protein damage, left ventricular end-systolic -diastolic diameter, suppressed fractional...
The parenchymal microglia possess different morphological characteristics in cerebral physiological and pathological conditions; thus, visualizing these cells is useful as a means of further investigating microglial function. Annexin A3 (ANXA3) expressed microglia, but it unknown whether can be used marker protein for its Here, we compared the distribution morphology labeled by ANXA3, cluster differentiation 11b (CD11b), ionized calcium-binding adaptor molecule 1 (Iba1) measured expression...
Chrysin (CHR) is a flavonoid with extensive pharmacological activity. The molecular formula of CHR C15 H10 O4 . reported to have antioxidative, antitumour and antiviral functions. To evaluate its potential function as vaccine adjuvant, we prepared melanoma using soluble protein extract B16F10 cells antigen an adjuvant. model was developed after two immunizations, it discovered that combining antigen-mixed could inhibit tumour growth in the mouse model, overall survival rate higher than...
Abstract Lung cancer is a fatal disease with the highest worldwide morbidity and mortality rates. Despite recent advances in targeted therapy immune checkpoint inhibitors for cancer, their efficacy remained limited. Therefore, we designed Newcastle virus (NDV)‐modified tumor whole‐cell vaccine as therapeutic identified its antigen presentation level to develop effective immunotherapy. Then, calculated immune‐stimulating effects of NDV‐modified lung cell intratumoral NDV injection combination...
Background This study was designed to investigate the effects of a novel carcinogenetic molecule, p130cas (breast cancer antiestrogen resistance protein 1 or BCAR1) on proliferation and cell growth in lung adenocarcinoma. The also aimed identify possible underlying signal networks BCAR1. Methods First, we evaluated proliferation, colony formation, apoptosis, cycle after BCAR1 knocked out (KO) using CRISPR‐Cas9 technology H1975 H1299 human adenocarcinoma cells. Subsequently, upregulated 293T...
We investigated the roles of breast cancer anti-estrogen resistance 1 (BCAR1/p130Cas) in formation and immunoevasion invasive circulating tumor cells (CTCs) lung adenocarcinoma (LUAD).
Angiogenesis plays an important role in the growth of solid tumors. To date, no information has been acquired on effectiveness gene therapy orthotopic lung cancer model syngeneic immunocompetent mice treated with angiogenesis inhibitor. Here, we report establishment such a which Lewis carcinoma (LL/2) cell suspensions were orthotopically inoculated into parenchyma C57BL/6 mice, also injected recombinant adenoviral vector delivering human endostatin (Ad-hE). We found that implantation LL/2...
Lenalidomide (Revlimid; Selleck Chemicals, Houston, TX, USA), an analogue of thalidomide, possesses potent cytokine modulatory capacity through inhibition cytokines such as tumour necrosis factor (TNF)-α, a pivotal for the onset and development complications in obesity diabetes mellitus. The present study was designed to evaluate effect lenalidomide on oxidative stress, protein DNA damage multiple organs ob/ob murine model obesity. To this end, C57BL/6 lean obese mice were administered (50...