A5100766228- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Gold and Silver Nanoparticles Synthesis and Applications
- RNA Interference and Gene Delivery
- Probiotics and Fermented Foods
- Plant Gene Expression Analysis
- Genomics and Phylogenetic Studies
- Biosensors and Analytical Detection
- Advanced Biosensing Techniques and Applications
- PI3K/AKT/mTOR signaling in cancer
- Gut microbiota and health
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Lipid Membrane Structure and Behavior
- Ionic liquids properties and applications
- Ubiquitin and proteasome pathways
- Enterobacteriaceae and Cronobacter Research
- Genetic diversity and population structure
- Antibiotics Pharmacokinetics and Efficacy
- Cancer-related Molecular Pathways
- Angiogenesis and VEGF in Cancer
- Endoplasmic Reticulum Stress and Disease
- CO2 Reduction Techniques and Catalysts
Sichuan University
2025
Nanjing University
2015-2024
China Pharmaceutical University
2023-2024
Xinxiang Medical University
2024
Hubei University of Chinese Medicine
2024
Fujian Medical University
2022
Union Hospital
2022
Qingdao University
2020
Tsinghua–Berkeley Shenzhen Institute
2019
Tsinghua University
2019
Abstract A structurally simple molecular 1,10‐phenanthroline‐Cu complex on a mesostructured graphene matrix that can be active and selective toward CO 2 reduction over H evolution in an aqueous solution is reported. The sites consist of Cu(I) center distorted trigonal bipyramidal geometry, which enables the adsorption with η 1 ‐COO‐like configuration to commence catalysis, turnover frequency ≈45 s −1 at V versus reversible hydrogen electrode. Using situ infrared spectroelectrochemical...
Viable microorganisms and a diverse microbial ecosystem found in human milk play crucial role promoting healthy immune system shaping the community infant's gut. Culturomics is method to obtain comprehensive repertoire of microbiota. However, culturomics an onerous procedure, needs expertise, making it difficult be widely implemented. Currently, there no efficient feasible specifically designed for microbiota yet. Therefore, aim this study was develop more We obtained fresh samples from...
Hexokinase II (HKII), a key enzyme of glycolysis, is widely over-expressed in cancer cells.3-bromopyruvate (3-BrPA), an inhibitor HK II, has been proposed as specific antitumor agent.Autophagy process that regulates the balance between protein synthesis and degradation.Autophagy mammalian systems occurs under basal conditions can be stimulated by stresses, including starvation, oxidative stress.Therefore, we hypothesized 3-BrPA could induce autophagy.In present study, explored mechanism its...
The effective capture and release of circulating tumor cells (CTCs) is significant importance in cancer prognose treatment. Here we report a highly efficient method to human leukemic lymphoblasts (CCRF-CEM) using aptamers modified gold nanowire arrays (AuNWs). nanowires, showing tunable morphologies from relatively random pillar deposit uniform arrays, were fabricated by electrochemical deposition anodic aluminum oxide (AAO) as template. Upon simply being with Au–S chemistry, the AuNWs...
A strategy is proposed to achieve an enhanced capture efficiency of and low damage human leukemic lymphoblasts (CCRF‐CEM) by the synergistic effect topographical interactions phenylboronic acid functional groups on nanostructures. To realize this purpose, a simple template free method synthesize boronic derivative polyaniline bioinspired nanostructures with controlled morphology established. Different nanostructured morphologies such as nanotexture, nanofibers, nanoparticles, microsphere, 3D...
Abstract Repetitive elements insertions (REIs), including tandem repeat (TRIs) and transposable element (TEIs), constitute >90% of large-scale (>50bp) somatic are linked to diseases cancer biomarkers. However, the genomic landscape REIs in pan-cancer has not been well-characterized due short-read sequencing limitations. Here, we detected 325 genomes across 12 types using long-read whole-genome customized algorithms. The diverse sequence patterns TRIs insertion mechanisms TEIs were...
microRNAs (miRNAs) play crucial roles in cancer development and progression by targeting mRNAs for degradation and/or translational repression. microRNA-802 (miR-802) has been reported as a tumor suppressor its deregulation is observed various human cancers. However, the prognostic value of miR-802 underlying mechanisms involved cervical are poorly investigated. The purposes this study were to explore role clarify regulation serine/arginine-rich splicing factor 9 (SRSF9) miR-802. Here, we...
A versatile and sensitive platform for label-free bioanalysis has been proposed on the basis of attenuated total reflection-surface enhanced infrared absorption spectroscopy (ATR-SEIRAS) using Au/ZnSe as enhancement substrate that allows a wide spectral range down to 700 cm–1. Au nanoparticles are stably deposited surface ZnSe prism due formation Au–Se bonds via electroless deposition, factor resultant is about 2 times larger than commonly used Au/Si substrate. As demonstration,...
The hexokinase inhibitor 3-bromopyruvate (3-BrPA) can inhibit glycolysis in tumor cells to reduce ATP production, resulting apoptosis. However, as 3-BrPA is an alkylating agent, its cytotoxic action may be induced by other molecular mechanisms. results presented here reveal that 3-BrPA-induced apoptosis caspase independent. Further, induces the generation of reactive oxygen species MDA-MB-231 cells, leading mitochondria-mediated These suggest caspase-independent species. In this study, we...
CELF6, a member of the CELF family RNA-binding proteins, regulates muscle-specific alternative splicing and contributes to pathogenesis myotonic dystrophy (DM), however role CELF6 in cancer cell proliferation is less appreciated. Here, we show that expression cycle regulated. The cycle-dependent mediated through ubiquitin-proteasome pathway, SCF-β-TrCP recognizes nonphospho motif its proteasomal degradation. Overexpression or depletion modulates p21 gene expression. binds 3'UTR transcript...
Hesperetin (HES) is a dihydroflavone with the molecular formula of C16H14O6. It has been reported that antioxidant and anticancer effects. Recent studies showed it can also regulate immune responses. To assess its potential function as vaccine adjuvant, we formulated HES inactivated B16F10 melanoma cells determined whether would enhance activation antigen-presenting by experiments in vivo vitro. We found activated PI3K-Akt signalling pathway (APCs), enhanced cytotoxic T lymphocyte (CTL)...
Selection breeding has played a key role in the improvement of seed yield and quality oilseed rape (Brassica napus L.). We genotyped Tapidor (European), Ningyou7 (Chinese) their progenitors with Brassica 60 K Illumina Infinium SNP array mapped total 29,347 markers onto reference genome Darmor-bzh. Identity by descent (IBD) refers to haplotype segment chromosome inherited from shared common ancestor. IBDs identified on C subgenome were larger than those A within both pedigrees. IBD number...
We demonstrate a core–satellite plasmonic nanoprobe assembled via metal-ion-dependent DNA-cleaving DNAzyme linker for imaging intercellular metal ion based on plasmon coupling effect at single-particle level. As ions are present in the system, will be cleaved, and thus, disassembly of nanoprobes occurs, which results distinct blue shift scattering spectra Au probes naked color change light. This has been supported by theoretical simulations. proof concept, sensitive detection Cu2+ with limit...
Monitoring the properties and reactions of biomolecules at their interface has attracted ever-growing interest. Here, we propose an approach infrared analysis technique that utilizes water molecule as a universal probe for in situ label free monitoring interfacial bioevents aqueous solution with high sensitivity. The strong (IR) signal O–H stretching vibrations from repelled is used to sensitively reveal kinetics molecular level based on steric displacement using attenuated total...
The Danggui Buxue decoction (DGBX), consists of Angelica sinensis (Oliv.) Diels, and Astragalus membranaceus (Fisch.) Bunge is known to replenish the blood. However, mechanisms underlying acute renal injury (ARI) as caused by DGBX are still unclear. Therefore, we aimed investigate pharmacological effects using a mouse model induced 1% HgCl2. key components were selected based on an assessment gastrointestinal absorption potential drug-likeness characteristics utilizing SwissADME tool. core...
Ulcerative colitis (UC) is an idiopathic inflammatory bowel disease, and the range of current clinical treatments not ideal. We previously found that polysaccharide Atractylodes macrocephala Koidz (PAMK) beneficial in DSS-induced colitis, we aimed to investigate underlying mechanisms this study.
The XieBai San (XBS) formula contains SangbaiPi (Cortex Mori), Digupi Lycii), and Gancao (Radix Glycyrrhizae). Some studies have shown that XBS exerts a healing impact on liver damage. However, the specific active components underlying mechanism are still not fully understood. To explore this phenomenon, we administered 0.2% CCl4 oil solution to mice elicit acute damage, then was given by gavage mice. results indicated exhibited beneficial injury. TCMSP, PubChem, SwissTargetPrediction,...
<title>Abstract</title> Artemisia argyi is a critical medical plant in China, containing high levels of essential oils and flavone, has been used to maintain health well-being. MYB transcription factors are the largest gene family plants widely reported play important roles development, metabolism, defense, stress resistance. However, not systematically examined. In our study, we characterized 227 AYMYB from genome data, 22 AY1R-MYB, 165 AYR2R3-MYB, 16 AY3R-MYB, 5 AY4R-MYB, 19 Atypical...