A5031753073- Liver physiology and pathology
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Hepatocellular Carcinoma Treatment and Prognosis
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Hippo pathway signaling and YAP/TAZ
- Virus-based gene therapy research
- Cancer-related gene regulation
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Telomeres, Telomerase, and Senescence
- Pancreatic function and diabetes
- Lung Cancer Treatments and Mutations
- Immune Response and Inflammation
Shanghai Cancer Institute
2021-2025
Second Military Medical University
2015-2024
Institute of Tibetan Plateau Research
2017-2024
University of Chinese Academy of Sciences
2024
Fujian Medical University
2024
Eastern Hepatobiliary Surgery Hospital
2014-2023
Changhai Hospital
2022
Taiyuan University of Science and Technology
2022
Guizhou Electromechanical Research and Design Institute
2018-2021
Chinese Academy of Sciences
2016-2020
The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of body plan and also tumor invasion process. In addition, EMT causes disruption cell-cell adherence, loss apico-basal polarity, matrix remodeling, increased motility invasiveness promoting metastasis. microenvironment an important role facilitating cancer metastasis may induce occurrence cells. A large number inflammatory cells infiltrating site, as well hypoxia existing a area tumor, addition many stem...
To estimate the distribution of lymphoid neoplasms in China, we conducted a comprehensive analysis, based on subtype, age, sex, and lesion, primary resected biopsy specimens 4,638 diagnosed from 2004 to 2008 at 5 large hospitals. Of patients, mature B-cell accounted for 64.3% all neoplasms, T/NK-cell 23.3%, Hodgkin lymphoma 8.6%. The most common subtype was diffuse (36.2%), followed by extranodal NK/T-cell lymphoma, nasal type (11.0%), classic (8.4%), marginal zone (7.7%), plasmacytic...
•CD10+ALPL+ neutrophils contribute to tumor resistance anti-PD-1 treatment in patients with HCC.•CD10+ALPL+ exhibit immunosuppressive features the microenvironment.•CD10+ALPL+ trigger irreversible T-cell exhaustion anti-PD-1-resistant patients.•Hepatoma cell-derived NAMPT-NTRK1 axis reprograms CD10+ALPL+ maintain an immature and state. Background & AimsRemodeling microenvironment is a critical strategy for treating advanced hepatocellular carcinoma (HCC). Yet, how distinct cell populations...
Hypoxia commonly exists in solid tumors. In this adverse condition, adaptive responses including autophagy are usually provoked to promote cell survival. our study, autophagy, a lysosomal-mediated degradation pathway, is demonstrated protective way make hepatocellular carcinoma cells be resistant chemotherapy under hypoxia. Compared with normoxia, chemotherapeutic agents-induced death hypoxia was significantly decreased, as result of the reduced apoptosis. However, when inhibited by 3-MA or...
Mesenchymal stem cells (MSCs), which are modulated by cytokines present in the tumor microenvironment, play an important role progression. It is well documented that inflammation part of so we investigated whether stimulation MSCs inflammatory would contribute to their ability promote growth. We first showed could increase C26 colon cancer growth mice. This growth-promoting effect was further accelerated when were pre-stimulated factors IFN-γ and TNF-α. At same time, demonstrated both...
MicroRNAs (miRNAs) have recently been proposed as a versatile class of molecules involved in regulation various biological processes. Although there is emerging evidence that some microRNAs can function oncogenes or tumor suppressors, the specific role miRNA human hepatocellular carcinoma (HCC) unclear at this point. In study, we examined microRNA expression profiles set 20 HCC specimens by microarray and quantitative real-time polymerase chain reaction. The results showed among samples...
Cell division cycle 20 (CDC20) encodes a regulatory protein interacting with the anaphase-promoting complex/cyclosome (APC/C) in cell and plays important roles tumorigenesis progression of multiple tumors. The present study aimed to investigate clinical significance CDC20 hepatocellular carcinoma (HCC) role HCC. By bioinformatics analysis, was found be major node HCC molecular interaction networks. Quantitative PCR western blot analyses were applied examine expression 16 paired primary...
SIRT1, a NAD+ dependent class III deacetylase, takes part in many important biological processes. Previous studies show that SIRT1 is overexpressed some cancers and plays an essential role tumorigenesis. However, the association between colorectal cancer (CRC) still unclear. We found CRC specimens had strong expression, which obvious correlation with poor prognosis of patients. Meanwhile, expression co-localization CD133, current universal marker to characterize stem cells (CSCs). In vitro...
Colorectal cancer (CRC), which frequently metastasizes to the liver, is one of three leading causes cancer-related deaths worldwide. Growing evidence suggests that a subset cells exists among stem cells. This distinct subpopulation thought contribute liver metastasis; however, it has not been fully explored in CRC yet.Flow cytometry analysis was performed detect subsets with CD133 and CXCR4 markers human primary metastatic tissues. The 'stemness' capacities different subpopulations derived...
Maternally Expressed Gene 3 (MEG3) encodes a lncRNA which is suggested to function as tumor suppressor. Previous studies that MEG3 functioned through activation of p53, however, the functional properties remain obscure and their relevance human diseases under continuous investigation. Here, we try illuminate relationship consequence in hepatoma cells. We find transfection expression construct enhances stability transcriptional activity p53. Deletion analysis confirms full length intact...
Stem cells were characterized by their stemness: self-renewal and pluripotency. Mesenchymal stem (MSCs) are a unique type of adult that have been proven to be involved in tissue repair, immunoloregulation tumorigenesis. Irradiation is well-known factor leads functional obstacle cells. However, the mechanism stemness maintenance human MSCs exposed irradiation remains unknown. We demonstrated could induce reactive oxygen species (ROS) accumulation resulted DNA damage injury MSCs. Autophagy...
Development of a tumor is very complex process, and invasion metastasis malignant tumors are hallmarks difficult problems to overcome. The microenvironment plays an important role in controlling fate autophagy induced by the attracting more attention. Autophagy can be several stressors modifies microenvironment, too. has dual roles growth. In this review, we discussed interaction between paradoxical on growth at different stages development.
Abstract Background The endotoxin level in the portal and peripheral veins of hepatocellular carcinoma (HCC) patients is higher lipopolysaccharide (LPS), a cell wall constituent gram-negative bacteria, has been reported to inhibit tumor growth. However, this study, we found that LPS-induced toll-like receptor 4 (TLR4) signaling was involved invasion survival, molecular mechanism investigated, Methods Four HCC lines splenic vein metastasis nude mouse model were used study ability cells...
Primary mediastinal germ cell tumors (GCTs) are rare and sometimes they pose diagnostic difficulty without immunohistochemical studies. Here, we investigated the utility of 6 stem markers (SCMs) SALL4, OCT4, NANOG, SOX2, UTF1, TCL1 in 16 primary seminomas, 3 embryonal carcinomas (ECs), 10 yolk sac (YSTs), 7 teratomas (4 mature, immature), 1 choriocarcinoma. The percentage tumor cells stained was scored as: 0 (no staining), 1+ (< or =30%), 2+ (31% to 60%), 3+ (61% 90%), 4+ (>90%). staining...
Background/Aims: TGF-β plays a key role in the progression of various tumors. The main objective our study was to investigate whether is able regulate N-nitrosodiethylamine (DEN)-induced hepatocellular carcinoma (HCC) mouse model by inducing Treg cell polarization. Methods: HCC progression, and Foxp3 expression levels, serum TGF-β, IL10 GP73 levels as well percentage cells were analyzed healthy, HCC+SM-16 groups. effect on polarization vitro measured flow cytometric analysis. identified IHC...
Autophagy serves as a dynamic degradation and recycling system that provides biological materials energy in response to stress. The role of autophagy tumor development is complex. Various studies suggest mainly contributes suppression during the early stage tumorigenesis promotion late tumorigenesis. During tumorization normal cells, protects genomic stability by retarding stem cells-involved damage/repair cycle, inhibits formation chronic inflammatory microenvironment, thus protecting cell...
Patients with colorectal cancer (CRC) often develop liver metastases, in which case surgery is considered the only potentially curative treatment option. However, associated a risk of ischemia-reperfusion (IR) injury, thought to promote growth metastases. The influence IR-induced tumor necrosis factor alpha (TNF-α) elevation process still unknown. To investigate role TNF-α pre-existing micrometastases following IR, we used mouse model In this model, mice received IR seven days after...