A5090839300- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- S100 Proteins and Annexins
- Cancer Cells and Metastasis
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Plant Stress Responses and Tolerance
- Neuroinflammation and Neurodegeneration Mechanisms
- Ureteral procedures and complications
- Liver physiology and pathology
- Cancer-related molecular mechanisms research
- Sepsis Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Hormonal Regulation and Hypertension
- Traumatic Brain Injury Research
- Immunotherapy and Immune Responses
- Ion Transport and Channel Regulation
- Stroke Rehabilitation and Recovery
- Kidney Stones and Urolithiasis Treatments
- Glioma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Pediatric Urology and Nephrology Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Heme Oxygenase-1 and Carbon Monoxide
Quzhou City People's Hospital
2016-2025
Wenzhou Medical University
2017-2025
Sichuan Agricultural University
2023-2024
China Tobacco
2024
Shanghai Sixth People's Hospital
2024
Weatherford College
2023
Quzhou University
2021
Wenzhou University
2021
Zhejiang Chinese Medical University
2020
Suzhou Traditional Chinese Medicine Hospital
2019
As the main source of extracellular matrix proteins in tumor stroma, hepatic stellate cells (HSCs) have a great impact on biological behaviors hepatocellular carcinoma (HCC). In present study, we investigated mechanism whereby HSCs modulate chemoresistance hepatoma cells. We used human HSC line lx-2 and chemotherapeutic agent cisplatin to investigate their effects HCC cell Hep3B. The results showed that resistance Hep3B was enhanced with LX-2 CM (cultured medium) exposure vitro as well...
Background: Patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH), defined as World Federation of Neurosurgical Societies (WFNS) grades IV–V have high rates disability and mortality. The objective this study was to accurately prognosticate the outcomes patients aSAH by developing a new scoring model. Methods: A total 147 in our center were enrolled. Risk variables identified multivariate logistic regression analysis used devise model (total score, 0–9 points). scores estimated...
The biological behaviors of hepatocellular carcinoma (HCC) are complex mainly due to heterogeneity progressive genetic and epigenetic mutations as well tumor environment. Hepatocyte growth factor (HGF)/c-Met signaling pathway is regarded be a prototypical example for stromal-epithelial interactions during developmental morphogenesis, wound healing, organ regeneration cancer progression. And p53 plays an important regulator Met-dependent cell motility invasion. Present study showed that 2 HCC...
Inflammatory cytokine is important in modulating injured diseases. Tumor necrosis factor-α (TNF-α), one of potent inflammatory cytokines, plays a dominant role host defense reaction. However, the concrete effect TNF-α on acute liver injury totally unclear. Here we reported and possible mechanisms induced by carbon tetrachloride (CCl4). SD male rats were equally divided into nine groups. CCl4 (1 ml/kg) was subcutaneously injected rats. Enbrel, inhibitor, intraperitoneally at dose 0, 0.25,...
Colorectal cancer (CRC) is the most commonly diagnosed worldwide, and over 50% of patients will develop hepatic metastasis during course their disease. CXCR4 its ligand, stromal cell-derived factor 1α (SDF-1α)/chemokine (C-X-C motif) ligand 12 (CXCL12) have been revealed as regulatory molecules involved in spreading progression a variety tumors. Here we shown that lipopolysaccharides (LPS) promoted migratory capacity colon cells vivo vitro, which correlated with activation SDF-1α/CXCR4 axis...
Spermidine synthase (SPDS) is a key enzyme in the polyamine anabolic pathway. SPDS genes help regulate plant response to environmental stresses, but their roles pepper remain unclear. In this study, we identified and cloned gene from (Capsicum annuum L.), named CaSPDS (LOC107847831). Bioinformatics analysis indicated that contains two highly conserved domains: an tetramerisation domain spermine/SPDS domain. Quantitative reverse-transcription polymerase chain reaction results showed was...
Traumatic brain injury (TBI) leads to permanent damage, including neurological deficits, cognitive and cerebral edema. The specific inhibitor of serine protease Omi/high-temperature requirement A2 (Omi/HtrA2), UCF-101, exerts neuroprotective effects, but its role in TBI remains unclear. Eighty-four male Sprague Dawley rats were randomized control, TBI, UCF-101 low dose (1.5 μmol/kg), middle (3.0 high (6.0 Compound C (AMPK inhibitor, 20 mg/kg), + groups. rat modeling was operated by the...
<title>Abstract</title> Background Complex kidney stones usually require multiple percutaneous tracts to remove the stone completely. This study was aim evaluate feasibility of super multiple-tract (≥ 5 tracts) minimally invasive nephrolithotomy (Mini-PCNL) in one session for treating complex renal stones. Methods From March 2019 August 2023, perioperative clinical data 35 patients with who underwent Mini-PCNL our institution were collected and analyzed, retrospectively. Results A total...
<title>Abstract</title> <bold>Object</bold> To evaluate the clinical feasibility of omitting routine urinary catheterization after RIRS for upper tract calculi. <bold>Methods</bold> In this study, 80 patients undergoing between June 2023 and 2024 were allocated into two groups: catheter-free group (n = 40) conventional (24-hour indwelling, n 40). Comprehensive analysis included perioperative parameters postoperative outcomes assessment. <bold>Results</bold> There was no significant...
Ductular reactions (DRs) are well documented in many acute and chronic liver disease. The DRs thought to be the transit amplifying cells deriving from activation of stem/progenitor cell compartments liver. aim this study was examine presence proliferative index DR (PI-DR) HPC markers' expression HCCs after curative hepatectomy, as their relationship with clinicopathological features prognosis. Tissue microarray peritumoral intratumoral tissue samples 120 hepatectomy analysed for...
Abstract Background The mediator complex subunits (MED) constitutes a multiprotein complex, with each subunit intricately involved in crucial aspects of plant growth, development, and responses to stress. Nevertheless, scant reports pertain the VunMED gene within context asparagus bean ( Vigna unguiculata ssp. sesquipedialis ). Establishing identification exploring responsiveness cold stress forms robust foundation for cultivation cold-tolerant cultivars. Results Within this study,...
Complement C1q is implicated in neuroinflammation. We intended to discern the relationship between serum levels and severity addition prognosis following traumatic brain injury (TBI).In this prospective, observational study, were quantified 188 TBI patients healthy controls. Glasgow coma scale (GCS) Rotterdam computed tomography (CT) classification used as clinical radiological indicators of severity. Patients with extended outcome (GOSE) score 1-4 at 6 months after trauma considered have a...
The aquaporin (AQP) family, which includes 13 members identified in mammalian cells, is involved cancer development and progression. AQP9 expression upregulated several tumor tissue types. However, the functions of astrocytoma remain elusive. present study that was expressed cells. silenced by transfection with small interfering RNAs increased a plasmid containing gene. Using invasion wound‑healing assays, it revealed knockdown suppressed cell motility, whereas overexpression promoted...
Tumor microenviroment is characteristic of inflammation, ischemia and starvation nutrient. TNF-α, which an extraordinarily pleiotropic cytokine, could be endogenous tumor promoter in some types. The basic objective this study was to investigate the effects TNF-α on cell viability apoptosis hepatocellular carcinoma cells under serum starvation, identify molecular mechanisms involved.For purpose, five different concentrations two settings (serum-cultured serum-deprived) were used Hep3B...