A5100425705- Chemical Reactions and Isotopes
- Cancer therapeutics and mechanisms
- Colorectal Cancer Treatments and Studies
- Cancer Cells and Metastasis
- Pharmacological Effects of Natural Compounds
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Helicobacter pylori-related gastroenterology studies
- NF-κB Signaling Pathways
- Cardiac Ischemia and Reperfusion
- bioluminescence and chemiluminescence research
- Medicinal Plants and Neuroprotection
- Drug-Induced Hepatotoxicity and Protection
- Blood properties and coagulation
- Nanocluster Synthesis and Applications
- Bioactive Compounds and Antitumor Agents
- Liver physiology and pathology
- Nigella sativa pharmacological applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal motility and disorders
- Immunotherapy and Immune Responses
- Alkaline Phosphatase Research Studies
- Ammonia Synthesis and Nitrogen Reduction
- Cancer Research and Treatments
- Natural product bioactivities and synthesis
Second Hospital of Anhui Medical University
2018-2025
Changhai Hospital
2012-2025
Anhui Medical University
2018-2025
Second Military Medical University
2012-2025
Zhengzhou University
2024
Yale Cancer Center
2021
Yale University
2021
Shandong Normal University
2020
Nankai University
2019
Inner Mongolia People's Hospital
2018
Colorectal cancer (CRC), which frequently metastasizes to the liver, is one of three leading causes cancer-related deaths worldwide. Growing evidence suggests that a subset cells exists among stem cells. This distinct subpopulation thought contribute liver metastasis; however, it has not been fully explored in CRC yet.Flow cytometry analysis was performed detect subsets with CD133 and CXCR4 markers human primary metastatic tissues. The 'stemness' capacities different subpopulations derived...
Deuteration has found important applications in synthetic chemistry especially for pharmaceutical developments. However, conventional deuteration methods using transition-metal catalysts or strong bases generally involve harsh reaction conditions, expensive deuterium source, insufficient efficiency, and poor selectivity. Herein, we report an efficient visible-light-driven dehalogenative of organic halides plasmonic Au/CdS as photocatalyst D2O donor. Electron transfer from Au to CdS, which...
Chimeric antigen receptor-T (CAR-T) cell therapy is a cellular immunotherapy that has emerged in recent years, and increasing studies showed therapeutic resistance to CAR-T presents colorectal cancer patients. Lipopolysaccharide (LPS), component of the wall Gram-negative bacteria, known preserve high concentration colon. Whether LPS contributing factor development cells against remains unclear. For vivo experiments, COLO205 were pretreated with for 24 h then injected into nude mice through...
Abstract Hepatic metastasis is the leading cause of mortality colon cancer, which still lack an effective therapy. A new delivery system, pluronic P85 block copolymers, conveying chemotherapeutic agent 5-fluorouracil (5-Fu) for inhibiting growth and cancer was designed developed. In this study, we demonstrated that 5-Fu produce strong pesticide effect at lower doses in present compared with control groups. The migration invasion HCT116 cells RKO were examined results showed capacities...
Sevoflurane postconditioning has been shown to provide neuroprotection against cerebral hypoxia-ischemia injury, but the mechanisms remain elusive. Microtubule-associated protein 2 (MAP2) is implicated in early neuronal injury. This study aimed investigate whether neuroprotective effects of sevoflurane are related Akt/GSK-3β pathway and its downstream target MAP2 zebrafish hypoxia/reoxygenation (H/R) model. or GSK-3β inhibitor TDZD-8 were used treat H/R zebrafish. The infarction, apoptosis,...
A nickel-catalyzed enantioselective transfer hydrogenation and deuteration of N-sulfonyl imines was developed. Excellent α-selectivity high deuterium content were achieved by using inexpensive 2-propanol-d8 as a source. As highlight, no β-C-H the remote C-H amines occurred, which is hard to achieve other or hydrogen isotope exchange with D2O. Mechanism studies indicated stepwise pathway through [Ni-D] intermediate.
Although chemotherapy plays a vital role in treating non‐Hodgkin lymphomas, the clinical applications are limited because of intolerable side‐effects and multidrug resistance at beginning or during course therapy. In this study, we successfully fabricated CD 20‐targeting immuno‐liposome based on 1,2‐bis(10,12‐tricosadiynoyl)‐sn‐glycero‐3‐phosphocholine ( DC ‐8,9 PC ), which can form intermolecular cross‐linking through diacetylenic group by ultraviolet irradiation. This showed appropriate...
Abstract Background: The pharmacokinetic and clinical behaviors of many proton pump inhibitors (PPIs) in peptic ulcer treatment are altered by CYP2C19 genetic polymorphisms. This non-inferiority study evaluated the efficacy safety novel PPI anaprazole compared with rabeprazole. We also explored influence Helicobacter pylori ( H. ) infection status polymorphism on anaprazole. Methods: In this multicenter, randomized, double-blind, double-dummy, positive-drug parallel-controlled, phase III...
Asiatic acid (1), a major pentacyclic triterpene of Centella asiatica, was subjected to transformation by Penicillium lilacinum ACCC 31890, Fusarium equiseti CGMCC 3.3658, and Streptomyces griseus 4.18 strains. Incubation asiatic with P. 31890 F. 3.3658 gave an identical product: 2α,3β,15α,23-tetrahydroxyurs-12-en-28-oic (2). Biotransformation S. resulted in three derivatives: 2α,3β,21β,23-tetrahydroxyurs-12-en-28-oic (3), 2α,3β,23-trihydroxyurs-12-en-28, 30-dioic (4),...
An efficient, green, and stereoselective synthesis of cis -(2 S ,3 )-2,3-dihydro-3-hydroxy-2-aryl-1,5-benzothiazepin-4(5 H )-ones was developed via ketoreductase-catalyzed dynamic reductive kinetic resolution.
The aim of this study was to examine the pharmacokinetics, bioequivalence, and safety two tablet formulations capecitabine 500 mg in Chinese patients with breast, colorectal or gastric cancer under fed condition.A multicentric, randomized, open-label, single-dose, two-period, two-way crossover trial conducted by randomizing a single oral dose test (T) reference (R, Xeloda®) (500 mg) either sex colon, breast condition (high-fat high-calorie diet). Pharmacokinetic parameters were calculated...
Background Hepatocellular carcinoma (HCC) is inflammation-related cancer. Persistent inflammatory injury of the liver an important factor mediating occurrence and development Hepatic macrophages play role in microenvironment, which mediates tumor immune escape, growth, metastasis. Previous studies have suggested that L-3,5,3-triiodothyronine (T3) can regulate inflammation; however, its use associated with serious cardiac side effects, hepatocarcinogenesis remains unclear. In this study, we...
Abstract Background Preclinical studies showed that HC‐1119, a deuterated version of enzalutamide, could competitively inhibit androgen binding to receptor by blocking the transmission signaling pathway as inducing apoptosis prostate cancer cells and reducing proliferation cells. Animal pharmacokinetic also show deuterization enzalutamide HC‐1119 retain basic properties mother drug, increases stability compounds metabolic enzymes drug exposure in vivo, prolong half‐life reduce production...
The heterogeneity of hepatocellular carcinoma (HCC) is linked to tumor malignancy and poor prognosis. Nevertheless, the precise mechanisms underlying development cholangiocellular phenotype (CCA) within HCC remain unclear. Emerging studies support that cross-talk among host cells microenvironment (TME) sustains cancer cell plasticity. This study sought identify specific types involved in formation CCA elucidate their functional roles progression HCC. Single-cell RNA sequencing was employed...
Babao Dan (BBD) is a traditional Chinese medicine that has been widely used as complementary and alternative to treat chronic liver diseases. In this study, we aimed observe the effect of BBD on incidence diethylnitrosamine (DEN)-initiated hepatocellular carcinoma formation in rats explored its possible mechanism.To verify hypothesis, was administrated at dose 0.5g/kg body weight per two days from 9th 12th week HCC-induced by DEN. Liver injury biomarkers hepatic inflammatory parameters were...
Objective To investigate the clinical efficiency and immune adjustment of oxymatrine capsule acitretin in treatment psoriasis.Methods Eighty patients with psoriasis were randomly divided into (T) control (C) groups.The T group took orally one (0.2g) three times a day (10 g) two day.The C only groups applied same drug for external use.Moreover,another 40 normal volunteers set as group.The peripheral blood cell subset CD3 +,CD4 +,CD8 +/CD8 + detected all (T,C,and normal) before after...
A 68-year-old male patient received apatinib 850 mg orally once daily for advanced gastric cancer with liver and lymph node metastasis despite previous treatments multiple lines of chemotherapy, which induced myelosuppression. About 1 month after the medication, developed fatigue poor appetite. Thyroid function tests showed serum free triiodothyronine (FT3), thyroxine (FT4), thyroid-stimulating hormone (TSH) levels 3.1 pmol/L, 9.9 pmol/L and, 8.9 mU/L. It was considered that hypothyroidism...