A5014222930- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Prostate Cancer Treatment and Research
- Advancements in Transdermal Drug Delivery
- Peroxisome Proliferator-Activated Receptors
- Nanoplatforms for cancer theranostics
- Cancer, Lipids, and Metabolism
- Advanced Drug Delivery Systems
- Dendrimers and Hyperbranched Polymers
- Cancer, Hypoxia, and Metabolism
- Immunotherapy and Immune Responses
- Analytical Methods in Pharmaceuticals
- Dermatology and Skin Diseases
- Gestational Diabetes Research and Management
- Advanced biosensing and bioanalysis techniques
- Pharmacological Effects of Natural Compounds
- Virus-based gene therapy research
- Cancer Immunotherapy and Biomarkers
- Pregnancy and preeclampsia studies
- Extracellular vesicles in disease
- Estrogen and related hormone effects
- Immune cells in cancer
- Analytical Chemistry and Chromatography
- Pancreatic and Hepatic Oncology Research
- Air Quality and Health Impacts
Beijing Obstetrics and Gynecology Hospital
2022-2025
Capital Medical University
2022-2025
Second Military Medical University
2015-2024
Changhai Hospital
2015-2024
Tampere University
2024
Shanghai Jiao Tong University
2023-2024
Tianjin Medical University
2020-2024
Second Hospital of Tianjin Medical University
2020-2024
Chinese PLA General Hospital
2022-2024
Fudan University
2020-2024
Exosomes (Exo) hold great promise as endogenous nanocarriers that can deliver biological information between cells. However, Exo are limited in terms of their abilities to target specific recipient cell types. We developed a strategy isolate exhibiting increased binding integrin αvβ3. Binding occurred through modified version disintegrin and metalloproteinase 15 (A15) expressed on exosomal membranes (A15-Exo), which facilitated co-delivery therapeutic quantities doxorubicin (Dox)...
Abstract Cell membrane- covered drug-delivery nanoplatforms have been garnering attention because of their enhanced bio-interfacing capabilities that originate from source cells. In this top-down technique, nanoparticles (NPs) are by various membrane coatings, including membranes specialized cells or hybrid combine the capacities different types cell membranes. Here, membrane-coated doxorubicin (Dox)-loaded poly(lactic-co-glycolic acid) (PLGA) NPs (DPLGA@[RAW-4T1] NPs) were fabricated fusing...
Biomedical micro/nanorobots as active delivery systems with the features of self-propulsion and controllable navigation have made tremendous progress in disease therapy diagnosis, detection, biodetoxification. However, existing are still suffering from complex drug loading, physiological stability, uncontrollable release. To solve these problems, nanocatalytic medicine two independent research fields were integrated this study to achieve self-propulsion-induced deeper tumor penetration...
PRMT5 (protein arginine methyltransferase 5) is an enzyme that catalyses transfer of methyl groups from S-adenosyl methionine to the residues histones or non-histone proteins and involved in a variety cellular processes. Although it highly expressed some tumours, its direct role cancer growth has not been fully investigated. In present study, human lung tissue samples we found was cells, whereas expression detectable benign tissues. Silencing strongly inhibited proliferation adenocarcinoma...
Abstract The combination of an immuno-metabolic adjuvant and immune checkpoint inhibitors holds great promise for effective suppression tumor growth invasion. In this study, a pH-responsive co-delivery platform was developed metformin (Met), known modulator, short interfering RNA (siRNA) targeting fibrinogen-like protein 1 mRNA (siFGL1), using hybrid biomimetic membrane (from macrophages cancer cells)-camouflaged poly (lactic- co -glycolic acid) nanoparticles. To improve the endo-lysosomal...
Abnormal metabolic symbiosis is a typical characteristic that differentiates the tumor regions from healthy tissues and meanwhile maintains survival. It of great potential to disrupt intratumoral in therapy. Herein, we report specific therapy strategy through inducing acidosis for elimination, which based on carbonic anhydrase inhibitor (CAI)-modified ferrous sulfide nanoparticles (FeS-PEG-CAI NPs). The FeS-PEG-CAI NPs show acid-responsive degradation capacity release functional components,...
The relationship between serum ferritin levels and the risk of gestational diabetes mellitus (GDM) remains unclear. This study aimed to investigate association incidence GDM. We conducted a prospective cohort involving 10,871 pregnant women from China Birth Cohort Study. Serum were measured using direct chemiluminescence method in first second trimesters. Baseline categorized into five groups according quintiles trimester, trimester-specific median values used divide four subgroups. GDM was...
This study aims to investigate the suitability of thermosensitive triblock polymer poly-(DL-lactic acid-co-glycolic acid) (PLGA)-polyethylene glycol (PEG)-PLGA as a matrix material for ocular delivery dexamethasone acetate (DXA).The copolymer was synthesized and evaluated its gelation properties. DXA in situ gel-forming solution based on PLGA-PEG-PLGA 20% (w/w) prepared pharmacokinetics rabbit according microdialysis method, which compared normal eye drop.The with had low critical...
20(R)-ginsenoside Rg3 (20(R)-Rg3) has shown multiple pharmacological activities and been considered as one of the most promising approaches for fatigue treatment. However, 20(R)-Rg3 a low bioavailability after oral administration in human due to first-pass effect. Recently, nasal route gained increasing interest it can avoid effect its lower enzymatic activity compared with gastrointestinal tract liver. In order provide an animal experimental evidence intranasal administrated preparation,...
The aim of this study was to investigate the suitability poly-(d,l-lactic acid-co-glycolic acid) (PLGA)-polyethylene glycol (PEG)-PLGA triblock copolymer as a matrix material for sustained-release system docetaxel (DTX). copolymers were synthesized by ring-opening polymerization reaction and characterized 1H-NMR gel permeation chromatography. DTX-loaded formulations prepared, characterized. And antitumor efficacy pharmacokinetics on A-549 lung tumor-bearing BALB/cA mice investigated. results...
Macrophages with tumor-tropic migratory properties can serve as a cellular carrier to enhance the efficacy of anti neoplastic agents. However, limited drug loading (DL) and insufficient release at tumor site remain main obstacles in developing macrophage-based delivery systems. In this study, we constructed biomimetic system (BDS) by doxorubicin (DOX)-loaded reduced graphene oxide (rGO) into mouse macrophage-like cell line (RAW264.7), hoping that newly BDS could perfectly combine ability...
Cancer immunotherapy can enhance the antitumor effect of drugs through a combinatorial approach in synergistic manner. However, effective targeted delivery various remains challenge. We generated peptide assembling tumor-targeted nanodelivery system based on breast cancer homing and penetrating for codelivery programmed cell death ligand 1 (PD-L1) small interfering RNA (siRNA) (siPD-L1) an indoleamine 2,3-dioxygenase inhibitor as dual blockade immune checkpoint. The vector is capable...
Until recently, there have been limited options for patients with bone metastatic castration-resistant prostate cancer (BmCRPC) following the failure of or development resistance to docetaxel (DTX), which is one frontline treatments.Sterol regulatory element-binding protein 1 (SREBP1) reported regulate abnormal lipid metabolism and promote progression metastasis (PCa).The siRNA interferes SREBP1 may provide an efficient treatment when combined DTX.Methods: In this study, lipoic acid (LA)...
Long noncoding RNA (lncRNA), urothelial carcinoma-associated 1 (UCA1) is aberrantly expressed in multiple cancers and has been verified as an oncogene. However, the underlying mechanism of UCA1 development gastric cancer not fully understood. In present study, we aimed to identify how promotes development.The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) data were used analyze myosin VI (MYO6) expression cancer. Western blot quantitative real-time PCR (QPCR) performed test...
The ferroptosis pathway is recognized as an essential strategy for tumor treatment. However, killing cells in deep regions with agents still challenging because of distinct size requirements intratumoral accumulation and penetration. Herein, intelligent nanocapsules size-switchable capability that responds to acid/hyperthermia stimulation achieve are developed. These constructed using poly(lactic-co-glycolic) acid Pluronic F127 carrier materials, Au-Fe
This prospective birth cohort study evaluated the association of exposure to PM2.5 (diameter ≤2.5 μm), PM1–2.5 (1–2.5 and PM1 (≤1 μm) with maternal thyroid autoimmunity function during early pregnancy. A total 15,664 pregnant women were included at 6 13+6 gestation weeks in China from 2018 2020. Single-pollutant models using generalized linear (GLMs) showed that each 10 μg/m3 increase was related 6% (odds ratio [OR] = 1.06, 95% confidence interval [CI]: 1.01, 1.12) 15% (OR 1.15, CI: 1.08,...
Introduction: Since intrinsic ocular barrier limits the intraocular penetration of therapeutic protein through eye drops, repeated intravitreal injections anti-vascular endothelial growth factor (anti-VEGF) agents are standard therapy for neovascular age-related macular degeneration (nAMD), which highly invasive and may cause particular complications, leading to poor patient compliance. Methods: Using Penetratin (Pen) as enhancer hyaluronic acid (HA) retina-targeting ligand, a dual-modified...
RNA-based delivery system for cancer therapy remains a challenge. In this study, stearyl-peptide (SHR) was synthesized using arginine, histidine, cysteine, and stearyl moieties. Further, the stearyl-peptides were cross-linked by disulfide bonds to obtain polypeptides (SHRss) with different molecular weight (SHRss1, SHRss2, SHRss3, SHRss4). The SHRss could effectively condense small interfering RNA (siRNA) into polyplexes hydrodynamic size of 100–300 nm zeta potential 20–40 mV. Flow cytometry...
Abstract APC mutations activate aberrant β-catenin signaling to drive initiation of colorectal cancer; however, cancer progression requires additional molecular mechanisms. PPAR-delta (PPARD), a downstream target β-catenin, is upregulated in cancer. However, promotion intestinal tumorigenesis following deletion PPARD Apcmin mice has raised questions about the effects on activation and In this study, we used mouse models overexpression or combined with mutation (ApcΔ580) epithelial cells...