A5048734861- Cancer-related molecular mechanisms research
- Mycobacterium research and diagnosis
- MicroRNA in disease regulation
- Graphene and Nanomaterials Applications
- Mast cells and histamine
- Drug-Induced Adverse Reactions
- Trace Elements in Health
- Advanced Glycation End Products research
- Pediatric Pain Management Techniques
- Circular RNAs in diseases
- Peroxisome Proliferator-Activated Receptors
- Lung Cancer Treatments and Mutations
- Pulmonary Hypertension Research and Treatments
- Vitamin C and Antioxidants Research
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Nanoparticle-Based Drug Delivery
- Heavy Metal Exposure and Toxicity
- Food Allergy and Anaphylaxis Research
- Carbon and Quantum Dots Applications
- Nanoplatforms for cancer theranostics
- FOXO transcription factor regulation
- Colorectal Cancer Treatments and Studies
- Extracellular vesicles in disease
- Graphene research and applications
Shandong First Medical University
2023
Academy of Medical Sciences
2023
Shaanxi University of Chinese Medicine
2023
East China University of Science and Technology
2020
Second Affiliated Hospital of Xi'an Jiaotong University
2019-2020
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2019-2020
Fudan University
2020
Second Military Medical University
2019
Changhai Hospital
2019
China Medical University
2014-2018
Macrophages with tumor-tropic migratory properties can serve as a cellular carrier to enhance the efficacy of anti neoplastic agents. However, limited drug loading (DL) and insufficient release at tumor site remain main obstacles in developing macrophage-based delivery systems. In this study, we constructed biomimetic system (BDS) by doxorubicin (DOX)-loaded reduced graphene oxide (rGO) into mouse macrophage-like cell line (RAW264.7), hoping that newly BDS could perfectly combine ability...
Abstract Background Enzalutamide (Enz) has shown limited bioavailability via oral administration. Castration-resistant prostate cancer (CRPC) is frequent among patients receiving 18–24 months of androgen deprivation therapy. The nonsteroidal anti-androgen enzalutamide used in the treatment Therefore, we developed a multifunctional enzalutamide-loaded graphene oxide nanosystem (TP-GQDss/Enz) for CRPC intravenous treatment, with high drug loading efficiency. Methods Aminated quantum dots...
Abstract Background This article focuses on the roles and mechanism of lncRNA CRNDE progression HCC. Methods We used qRT-PCR to detect expression in HCC cells, normal cells clinical tissues. MTT assay, FCM analysis, Transwell migration invasion assay were effects cell viability, apoptosis, cells. The apoptosis-related proteins Bcl-2, Bax, Cleaved Caspase 3, 9, EMT epithelial marker E-cadherin mesothelial Vimentin analyzed by Western blot. Online prediction software was predict binding sites...
Hepatic ischemia-reperfusion (I/R) injury frequently occurs after liver transplantation, stroke, and trauma, resulting in organ dysfunction failure. Hepatocyte apoptosis inflammation are identified as the hallmarks of I/R injury. Long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is induced following hypoxia or ischemic stimulation, exerts contradictory roles various progression. However, its role mechanism lying beneath hepatic remains ill defined....
Mast cells play an important role in inflammatory and allergic diseases. MAS-related G protein-coupled receptor X2 (MRGPRX2) is a novel mast that mediates drug-induced anaphylactoid reactions. Piperine has been reported to have anti-inflammatory anti-allergic pharmacological activities. However, whether the effects are regulated by MRGPRX2 not yet reported. The purpose of this study was assess anti-anaphylactoid effect explore its potential mechanism. assessed vivo mouse hindpaw...
Background: Homeobox B5 (HOXB5) is associated with the poor prognosis of various cancer types. However, specific mechanism by which HOXB5 promotes malignant progression pancreatic (PC) remains to be determined.Methods: The Cancer Genome Atlas database indicated expression level correlated PC prognosis. biological functions was confirmed colony formation, migration, and invasion assays. effects on stem cell epithelial–mesenchymal transition markers were evaluated. downstream target miR-6723,...
BACKGROUND The aim of this study was to detect the expression fork-head box D3 (FOXD3) and investigate its diagnostic value in patients with non-small cell lung cancer (NSCLC). MATERIAL AND METHODS relative FOXD3 at mRNA protein levels determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR) Western blotting analysis, respectively. Chi-square test used explore relevance clinical features NSCLC patients. A receiver operating characteristic (ROC) curve built...
Abstract Background This article focuses on the roles and mechanism of lncRNA CRNDE progression HCC. Methods We used qRT-PCR to detect expression in HCC cells, normal cells clinical tissues. MTT assay, FCM analysis, Transwell migration invasion assay were effects cell viability, apoptosis, cells. The apoptosis-related proteins Bcl-2, Bax, Cleaved Caspase 3, 9, EMT epithelial marker E-cadherin mesothelial Vimentin analyzed by Western blot. Online prediction software was predict binding sites...
The majority of patients that suffer a stroke have excessive sputum, which accelerates the development pulmonary complications. However, it is unclear whether cerebral ischemia and reperfusion (I/R) injury induces mucus hypersecretion, potential role inflammation remains unknown. In present study, reversible middle artery occlusion model was applied in rats to induce I/R injury. were grouped according duration (6, 12, 24, 48 72 h). Neurological dysfunction evaluated by Longa scoring lung...
Abstract Background This article focuses on the roles and mechanism of lncRNA CRNDE progression HCC. Methods We used qRT-PCR to detect expression in HCC cells, normal cells clinical tissues. MTT assay, FCM analysis, Transwell migration invasion assay were effects cell viability, apoptosis, cells. The apoptosis-related proteins Bcl-2, Bax, Cleaved Caspase 3, 9, EMT epithelial marker E-cadherin mesothelial Vimentin analyzed by Western blot. Online prediction software was predict binding sites...
Abstract Background Resolvin D1 could reduce the inflammatory, catabolic response of OA chondrocyte, and promote repair various tissues.Our goal was to explore whether RvD1 inhibit NLRP3/caspase-1 signaling pathway, slow down occurrence pyroptosis chondrocytes, then proliferation chondrocytes articular cartilage. Methods Animal care use protocols comply with National Institutes Health Guide for Care Use Laboratory Animals.After rat osteoarthritis model established, injected a control group...
Gastric cancer is one of the most common malignant tumors in world, with poor prognosis and main cause cancer-related death.The 5-year survival rate early gastric can reach 90%.However, due to low diagnosis cancer, patients are diagnosed as advanced at first visit.Therefore, order improve patients, particularly important.At present, tumor serum markers such carcinoembryonic antigen (CEA), antibodies Helicobacter pylori, histopathology, endoscopy, determination digestiogen methods for...
Abstract Background This article focuses on the roles and mechanism of lncRNA CRNDE progression HCC. Methods We used qRT-PCR to detect expression in HCC cells, normal cells clinical tissues. MTT assay, FCM analysis, Transwell migration invasion assay were effects cell viability, apoptosis, cells. The apoptosis-related proteins Bcl-2, Bax, Cleaved Caspase 3, 9, EMT epithelial marker E-cadherin mesothelial Vimentin analyzed by Western blot. Online prediction software was predict binding sites...